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O. O. H. S. I. T. L. I. G. UMUM. Departement of Histologi Medical Faculty of Jambi University. Reference:. Wonodirekso Sugito. Penuntun Praktikum Histologi, Edisi 1. Jakarta Pusat : Penerbit Dian Rakyat, 2003

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  1. O O H S I T L I G UMUM Departement of Histologi Medical Faculty of Jambi University

  2. Reference: • Wonodirekso Sugito. Penuntun Praktikum Histologi, Edisi 1. Jakarta Pusat : Penerbit Dian Rakyat, 2003 • Eroschenko , Victor P. ATLAS HISTOLOGI di Fiore dengan Korelasi Fungsional / Victor P Eroschenko; alih bahasa, Jan Tambayong; editor edisi Bahasa Indonesia, dewi anggraini, Edisi 9. Jakarta: EGC, 2003 • Blom, Fawcett DW. A Textbook of HISTOLOGY. Igaku- Shoin/ Saunders, London, Twelf Edition, 1994 • Junqueira, L. Carlos. Histologi Dasar; alih bahasa, Jan Tambayong; editor, Sugiarto Komala. Ed. 8. Jakarta: EGC, 1998

  3. HISTOS = jaringan, anyaman ; LOGOS = ilmu pengetahuan Ilmu jaringan tubuh 1771-1802 : BICHAT , pertama kali mengungkap kata JARINGAN =TISSU 1819 : A.F. J.K MAYER seorang ahli mikkroskopik yang pertama kali memberikan istilah HISTOLOGI Istilah HISTOLOGI berkembang bersama sama dg berkembangnya Histologi ?

  4. Histologi adalah cabang ilmu kedokteran yang mempelajari struktur dan sifat jaringan dan organ tubuh untuk menjelaskan fungsinya dalam keadaan normal, termasuk perubahannya sepanjang usia dan dalam keadaan sakit. • Histologi termasuk dalam bidang Ilmu Kedoktaran Dasar Umum (IKDU) setingkat dengan Mata Kuliah Dasar Umum (MKDU). Histologi didasari oleh Ilmu Biologi dan Anatomi (Gross Anatomy). Histologi secara langsung mendasari Fisiologi, Patologi Anatomi, dan Patologi Klinik dan secara tidak langsung mendasari pengertian mengenai proses perubahan jaringan akibat usia dan penyakit

  5. HISTOLOGI UMUM Mempelajari macam macam jaringan tentang susunan mikroskopik, asal, fungsi jaringan epitel jaringan penyambung jaringan otot jaringan saraf

  6. HISTOLOGI KHUSUS Mempelajari organ organ tubuh Sistem kardiovaskuler, getah bening,darah Sistem limfoid Sistem percernaan makanan Sistem pernafasan Kelenjar endokrin Sistem uropoetikum Sistem kelamin pria dan wanita Kulit dan derivatnya Pancaindra

  7. Jaringan histologi Umumnya dengan perwarnaan H.E (hematoksilin –eosin) Warna biru hematoksilin, bersifat basa, akan berikatan dengan inti sel yang bersifat asam Warna merah eosin, bersifat asam , akan berikatan dengan sitoplasma yang bersifat basa atau asam sehingga memberi warna biru atau merah. Sitoplasma berwarnabiru kalau sel sedang aktif, dan berwarna merah kalau sel sedang inaktif.

  8. Departement of Histologi Medical Faculty of Jambi University Tim Pengajar Kepala Bagian : dr. Nyimas Natasha A.S Anggota : dr. Amelia Dwi Fitri dr. Hasna Dewi dr. Rita Halim Materi : Histologi Blok IV ( Sel dan Jaringan ) Histologi Blok V ( Sistem )

  9. Histologi Blok IV : 1. Jaringan Epitel 2. Kelenjar 3. Jaringan otot 4. Jaringan saraf 5. Jaringan penyambung dan Tulang 6. Organosensoris ( mata, kulit, telinga )

  10. TATA TERTIB PRAKTIKUM HISTOLOGI • Hadir tepat waktu • Toleransi waktu 15 menit • 2. Pakaian : • - Jas lab • - sepatu • 3. Alat Tulis dan buku • - Pensil Warna dan buku gambar A4 bersampul kertas • kopi dengan identitas (nama, Nim, kelas, blok ) • - Buku Penuntun Praktikum UI • 4. Wajib mengikuti Pre test ( materi sesuai praktikum )

  11. 5. Bertanggung jawab terhadap - Mikroskop - Preparat praktikum Nama preparat

  12. JARINGAN EPITEL Slide 001

  13. Pendahuluan Tubuh : Sel : unit terkecil yg b’reproduksi &tumbuh Jar.: gab sel dan zat Antar sel Organ: gab sejmlah jar.yg memiliki fungsi khusus Sistem : gab.sejumlah organ dengan f/majemuk

  14. Tingkat Cellular Interaksi molecular Tingkat Tissue/jaringan Sel yang sama → fungsi spesifik Tingkat Organ ≥ 2 tissues → fungsi spesifik Tingkat Organ system ≥ 2 organ → fungsi spesifik Tingkat Organisme Organ systems = hidup STRUKTUR TUBUH MANUSIA

  15. Jaringan epitel td1. Membran epitelial2. Kelenjar

  16. Karakteristik Jaringan yang disusun oleh kelompok sel-sel yang tersusun rapat (sel-sel polihedral yang berhimpit padat ) Sebagian besar permukaannya saling kontak satu sama lain Zat antarsel sedikit Nonvaskular Menutupi permukaan luardan dalam tubuh Melapisi atau membatasi lumen organ Melekat pada membrana basalis Membran epitelial

  17. Jaringan epitel ?

  18. Asal membran epitelial • Ektoderm :sel epitel otak , medulaspinalis, kulit, batas rongga mulut,hidung, kanalis auditoris eksternus, membrana timpani, mata,kelenjar • keringat, dan kelenjar sebasea • Mesoderm : saluran urogenital • Entoderm :epitel dan kelenjar sal.penc.dari esofagus  rektum, hepar, vesika velea dan pankreas. • Ektoderm :sel epitel otak,medula spinalis, kulit, batas rongga mulut,hidung, kanalis auditoris eksternus, membrana timpani, mata,kelenjar keringat, dan kelenjar sebasea • Mesoderm :saluran urogenital • Entoderm :epitel dan kelenjar sal.penc.dari esofagus sampai ke rektum, hepar, vesika velea dan pankreas.

  19. ` KLASIFIKASI Berdasarkan jumlah lapisan sel/susunan sel dan morfologi sel permukaan Berdasarkan jumlah/susunan lapisan sel: • Epitel selapis/ simple epitel • Epitel berlapis/stratified epitel/ complex epitel. • Epitel bertingkat/pseudostratified epitel/ berlapis semu • Epitel transisional Berdasarkan bentuknya: • Gepeng/pipih/squamos • Kubis/ cuboidal • Silindris/columnar/torak Slide 006

  20. • Structural Classification Epithelial Tissues Cell Shapes Cell Layers

  21. • Structural Classification Cell Shapes Squamous Cuboidal Columnar

  22. Simple Cell layers

  23. Stratified

  24. Epithelia: Simple Squamous • Single layer of flattened cells with disc-shaped nuclei and sparse cytoplasm • Functions • Diffusion and filtration • Provide a slick, friction-reducing lining in lymphatic and cardiovascular systems • Present in the kidney glomeruli, lining of heart, blood vessels, lymphatic vessels, and serosae

  25. Simple squamous epithelium (kidney glomeruli) 1. Epitel selapis gepeng

  26. Epithelia: Simple Cuboidal • Single layer of cubelike cells with large, spherical central nuclei • Function in secretion and absorption • Present in kidney tubules, ducts and secretory portions of small glands, and ovary surface

  27. Epithelia: Simple Cuboidal Figure 4.2b

  28. Simple cuboidal epithelium

  29. Epithelia: Simple Columnar Single layer of tall cells with oval nuclei; many contain cilia Goblet cells are often found in this layer Function in absorption and secretion Nonciliated type line digestive tract and gallbladder Ciliated type line small bronchi, uterine tubes, and some regions of the uterus Cilia help move substances through internal passageways

  30. Epithelia: Simple Columnar

  31. Simple columnar epithelium Parotid gland, Simple columnar epithelium. Identify: Columnar cells and their nuclei nuclei Basal infoldings of the plasma membrane.

  32. Note goblet cells

  33. Epitel selapis/simple ? Simple squamous epith. Simple cuboidal epith. Simple columnar epith. Slide 007

  34. Thick membrane composed of several layers of cellsFunction in protection of underlying areas subjected to abrasion Forms the external part of the skin’s epidermis (keratinized cells), and linings of the esophagus, mouth, and vagina (nonkeratinized cells) Epithelia: Stratified Squamous

  35. Epithelia: Stratified Squamous Figure 4.2e

  36. Stratified squamous epithelium keratinized

  37. Stratified squamous epithelium nonkeratinized

  38. Epithelia: Stratified Cuboidal and Columnar • Stratified cuboidal • Quite rare in the body • Found in some sweat and mammary glands • Typically two cell layers thick • Stratified columnar • Limited distribution in the body • Found in the pharynx, male urethra, and lining some glandular ducts • Also occurs at transition areas between two other types of epithelia

  39. Stratified cuboidal epithelium Stratified columnar epithelium

  40. Epithelia: Pseudostratified Columnar Single layer of cells with different heights; some do not reach the free surface Nuclei are seen at different layers Function in secretion and propulsion of mucus Present in the male sperm-carrying ducts (nonciliated) and trachea (ciliated)

  41. Pseudostratified Columnar Epithelium

  42. Pseudostratified epithlium

  43. Trachea, pseudostratified columnar epithelium Identify The pseudostratified ciliated epithelium Pseudostratified columnar epithelium

  44. Epithelia: Pseudostratified Columnar

  45. Pseudostratified epithlium

  46. Epithelia: Transitional Several cell layers, basal cells are cuboidal, surface cells are dome shaped Stretches to permit the distension of the urinary bladder Lines the urinary bladder, ureters, and part of the urethra

  47. Transitional Epithelium

  48. Bladder, transitional epithelium, Identify: The transitional epithelium The pear-shaped to cuboidal most superficial cells Transitional epithelium

  49. Epitel berlapis/stratified epitel ? Str. Squamous epith. Str. Cuboidal epith. Str. Columnar epith.

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