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on-off flickering

on-off flickering. voltage-dependent block by proton. node of Ranvier. 2-barrier model for proton block. well. outside. voltage-dependent block with TEA. K-depolarized squid giant axon. Time course of block by C9. squid giant axon. TTX-blocked iNa.

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on-off flickering

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  1. on-off flickering

  2. voltage-dependent block by proton node of Ranvier

  3. 2-barrier model for proton block well outside

  4. voltage-dependent block with TEA K-depolarized squid giant axon

  5. Time course of block by C9 squid giant axon TTX-blocked iNa internal C9 0.11 mM (nonyltriethylammonium)

  6. Concentration-dependent block internal TPeA (tetrapentylammonium) + 120 mV

  7. Armstrong’s hypothesis for QA block QA (quaternary ammonium)

  8. use-dependent block with lidocaine node of Ranvier, - 20 mV

  9. internal NMS (N-methylstrychnine)

  10. QX-222 (quaternary lidocaine) nicotinic AChR frog sartorius muscle -125 mV -150mV -120mV -120mV -150mV

  11. multi-ion block in a long pore selectivity filer

  12. voltage-dependent multi-ion block [K]o = 25 mM

  13. flickering block by external Cs+ tunricate egg Inward rectifier 200 mM [K]o 10 M [Cs]o

  14. Long block dwell times with TTX and STX batrachotoxin-Na channel, rat brain synaptosomes symmetrical 200 mM NaCl, +50 mV

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