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FIND and Operational Research in HIV-Associated Tuberculosis

FIND and Operational Research in HIV-Associated Tuberculosis. Rick O’Brien Foundation for Innovative New Diagnostics, Geneva. FIND was established in 2003 with a grant from the Bill and Melinda Gates Foundation FIND is based in Geneva as a Swiss tax-exempt foundation

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FIND and Operational Research in HIV-Associated Tuberculosis

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  1. FIND and Operational Research in HIV-Associated Tuberculosis Rick O’Brien Foundation for Innovative New Diagnostics, Geneva

  2. FIND was established in 2003 with a grant from the Bill and Melinda Gates Foundation FIND is based in Geneva as a Swiss tax-exempt foundation FIND is the only public / private partnership wholly dedicated to improved diagnostic technologies for infectious disease endemic in developing countries FIND’s initial focus is on tuberculosis Background and History

  3. FIND’s mission is to accelerate the development, evaluation, and appropriate use of high-quality yet affordable diagnostic tools for infectious diseases in developing countries. FIND’s mission

  4. FIND SCOPE OF ACTIVITIES Upstream ’ s focus Downstream FIND Market access Discovery and distribution and research - Demonstration Development Evaluation Large - scale Facilitate, Regulatory - projects Proof of Product Efficacy Effectiveness co - fund, quality measuring principle in box Data Data co - develop lab & field feasibility and trials impact on disease control programs

  5. Industry approach Access Liaise with funders, NGO’s, health ministries and agencies, e.g., GDF and GFATM Demonstration Evaluation Regulatory quality lab and field trials Large scale projects to measure feasibility and impact on disease control programs Development FIND ACTIVITY Research Liaison with funders, pharmaceutical and biotechnology companies, research institutes and academia Facilitate, co- fund and co- develop Proof of principle Product in box Efficacy data Effectiveness data FIND focus Create network of public and private partnerships to create effective tests and demonstrate theireffectiveness

  6. easy & robust lab procedures support for multiple health problems universal platforms dedicated POC devices minimal skill requirements segmentation - diagnostic question vs. health system level RESOLUTION faster than culture ! DETECTION more sensitive than smear !

  7. Feasibility Development Evaluation Demonstration Access Feasibility Development Evaluation Feasibility Development Evaluation Feasibility Development Evaluation FIND product timeline Development Evaluation Access Feasibility Demonstration 2005 2006 2007 2008 2009 Health center Breath test Adapted AFB Ag detection Serology Automated AFB Simple NAAT Feasibility Development Evaluation District lab TK Devel Evaluation Demonstration Access Fastplaque Development Evaluation Demonstration Robust NAAT Fea Development Evaluation MGIT Demonstration Access Central lab Current NAAT Demonstration Access

  8. Formal agreement with BD Dec 04 FIND to undertake CF and DST demo projects BD to supply MGIT equipment/reagents at “affordable” price to public sector in HBCs FIND objectives Demonstrate feasibility and impact of MGIT Provide data for WHO recommendations FIND-BD MGIT Demonstration Projects

  9. FIND-CREATE MOU Dec 04 MGIT culture in support of studies in Zambia, South Africa, and Brazil Under discussion GAP/PATH/Tanzania NTLP WHO/CDC/RIT-JICA/FHI/Cambodia MOH AMPATH (Eldoret, Kenya) FIND-BD MGIT TB/HIV Case-Finding Demonstration Projects

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