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Lecture 13 Sept. 6, 2006

Lecture 13 Sept. 6, 2006. Fatty Acid Synthesis (Conlusion) Cholesterol Synthesis (Introduction) Lehninger (4 th Edition), Chapter 21 Amino Acid Oxidation (Introduction) Urea Cycle Lehninger (4 th Edition), Chapter 21. LNC Fig. 21-5. LNC Fig. 21-5. LNC Fig. 21-5. LNC Fig. 21-5.

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Lecture 13 Sept. 6, 2006

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  1. Lecture 13Sept. 6, 2006 • Fatty Acid Synthesis (Conlusion)Cholesterol Synthesis (Introduction)Lehninger (4th Edition), Chapter 21 • Amino Acid Oxidation (Introduction)Urea Cycle Lehninger (4th Edition), Chapter 21

  2. LNC Fig. 21-5

  3. LNC Fig. 21-5

  4. LNC Fig. 21-5

  5. LNC Fig. 21-5

  6. LNC Fig. 21-5

  7. LNC Fig. 21-5

  8. LNC Fig. 21-5

  9. LNC Fig. 21-5

  10. beginning of the second round: LNC Fig. 21-6

  11. LNC Fig. 21-7

  12. To make palmitic acid (16 carbons) • need 8 acetyl CoAs • need 7ATPs to make 7 malonyl CoAs • Need 7 x 2 NADPH

  13. The normal product of fatty acid synthase is palmitate (16 carbons) elongation to stearate and longer chains takes place in the endoplasmic reticulum (ER) desaturation to oleate also occurs in the ER poly-unsaturated the shaded fatty acids are essential FA for humans but are made only in plants LNC Fig. 21-13

  14. LNC Fig. 21-8

  15. LNC Fig. 21-9 Source of NADPH Malic enzyme is found in liver and other animal tissues A similar enzyme is found in bundle sheath cells in C4 plants

  16. Source of NADPH

  17. Source of NADPH photosynthesis

  18. from Glucose to Fatty Acids glucose pyruvate (in cytosol) pyruvate acetyl-CoA (in mitochondria) acetyl-CoA fatty acid (in cytosol) How does acetyl-CoA come out of mitochondria ?

  19. From glucose to fatty acids mitochondria cytosol LNC Fig. 21-11

  20. Biosynthesis of cholesterol steroids isoprenoids LNC pp. 799

  21. LNC Fig. 21-30

  22. HMG-CoA KETONE BODIES CHOLESTEROL LNC Fig. 21-32

  23. HMG-CoA KETONE BODIES CHOLESTEROL LNC Fig. 21-32

  24. LNC Fig. 21-41

  25. HMG-CoA Reductase Inhibitors LNC Fig. 21-42

  26. Polyisoprene CH3 CH3 CH2 C CH CH2 CH2 C CH CH2 n

  27. LNC Fig. 21-36

  28. D3-isopentenyl pyrophosphate VITAMIN D STEROID HORMONES RUBBER OTHER VITAMINS DOLICHOLS CAROTENOIDS QUINONE PLANT HORMONES C | CH2 = C – CH2 – CH2 – O - P - O - P LNC Fig. 21-48

  29. Skip several pages in chapter 21 (pp.784 - 798) read p.785 about function/mechanism of aspirin, ibuprofen and other painkillers and related drugs

  30. LNC Fig. 21-37a

  31. LNC Fig. 21-38

  32. LNC Fig. 21-40

  33. METABOLIC BIOCHEMISTRY Lecture 14 Sept. 6, 2006 TRANSAMINATIONS THE UREA CYCLE

  34. AMINO ACID OXIDATION PRODUCTION OF UREA • LNC Chapter 18

  35. TURNOVER FOOD LNC 18-1

  36. LNC 18-2a

  37. LNC 18-8

  38. LNC 18-5a, b

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