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Innate + adaptive immunity

Innate + adaptive immunity. Innate immunity only. From Thomas C. G. Bosch (Kiel). Innate Immunity (NK cells, DC, Neutrophils, Monocytes/Macrophages). Effector Functions. « Pathogens ». Initiation of Ag-specific response. Adaptive Immunity (T and B Lymphocytes ). Figure 2-1.

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Innate + adaptive immunity

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  1. Innate + adaptive immunity Innate immunity only From Thomas C. G. Bosch (Kiel)

  2. Innate Immunity (NK cells, DC, Neutrophils, Monocytes/Macrophages) Effector Functions « Pathogens » Initiation of Ag-specific response Adaptive Immunity (T and B Lymphocytes )

  3. Figure 2-1

  4. Toll-like Receptors (TLR):innate immune sensors Toll and TLRs

  5. Nat Rev Immunol. 2004 Jul;4(7):521-7. The road to Toll. Lemaitre B. Centre de Genetique Moleculaire, Centre National de la Recherche Scientifique, F-91198 Gif-sur-Yvette, France. lemaitre@cgm.cnrs-gif.fr

  6. Toll-like receptors ssRNA IMQ CpG IMQ dsRNA Flagellin LPS Zym, LP PG, LP LP 1 2 3 4 5 6 7 8 9 10

  7. Figure 2-16 part 1 of 2

  8. Figure 2-16 part 2 of 2

  9. Figure 2-17

  10. hKIR TREM Ig-SF NCR m PIR h LIR (ILT) NKRP-1 mLY49 NKG2D C-type Lectins Mannose Rec. (MR, Endo180, DEC205, PLA2R) DC-SIGN receptors Dectin-2 (NCCL) Langerin BDCA-2 (DLEC) TLR Others (LRR, CARD,…) NOD molecules TLR

  11. Figure 2-5

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