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Presented By Dr. Md. Mahmudul Hasan M,Phil (Microbiology, P- I)

Presented By Dr. Md. Mahmudul Hasan M,Phil (Microbiology, P- I). EDIBLE VACCINES : CURRENT STATUS AND FUTURE. What is Edible Vaccine ?. Edible Vaccine involves introduction of selected desired genes into plant and then inducing these altered plants to manufacture the altered protein.

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Presented By Dr. Md. Mahmudul Hasan M,Phil (Microbiology, P- I)

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  1. Presented By Dr. Md. Mahmudul Hasan M,Phil (Microbiology, P- I) EDIBLE VACCINES : CURRENT STATUS AND FUTURE

  2. What is Edible Vaccine ? • Edible Vaccine involves introduction of selected desired genes into plant and then inducing these altered plants to manufacture the altered protein.

  3. How it acts ? • Antigen in transgenic plant > Ingestion >Delivered by bioencapsulation >Taken up by Mcell > Pass on to the Macrophage >IgG,IgE responses > Local IgA response & Memorycells > Neutralize the attack by the real infectious agent.

  4. Advantage and Disadvantage of different plants • Potato : Advantage Easily transformed. Easily propagated. Stored for long periods without refrigeration. Disadvantage Need cooking which denature antigen.

  5. Advantages and Disadvantages • Banana Advantages Do not need cooking. Protein not destroyed even after cooking. Inexpensive . Grown widely in developing countries. Disadvantages Trees take 2-3 to mature years. Spoils rapidly after ripening.

  6. Advantages and Disadvantages • Rice Advantages Commonly used in baby food. High expression of antigen. Disadvantages Grows slowly. Requires glasshouse condition.

  7. Advantages and Disadvantages • Potato Advantage Grow quicly. Cultivate broadly. High content Vitamin-A may boost immune response. Disadvantages Spoils readily.

  8. Clinical Trial on ETEC : 11 Volunteers were feed raw transgenic Potatoes expressing LT-B. 10 (95%) of these individuals developed neutralizing antibodies and 6 (55%)develop mucosal response.

  9. Clinical Trial on • Norwalk Virus 20 people fed with transgenic potato . 19 (95%)of them expressing Norwalk virus antigen showed seroconversion.

  10. Clinical Trial on • Hepatitis B First human trials of potato-based vaccine against Hepatitis B have reported encouraging results. The amount of HBsAg needed for one dose could be achieved in a single potato. Levels of specific antibodies significantly exceeded the protective level of 10mIU/mL in human.

  11. Advantages of Edible Vaccine • Cost effective. • Easy to administer. • Easy to store. • Acceptable to poor developing country. • Fail safe • Activate both mucosal and systemic immunity. • Heat stable. • Do not required cold chain maintenance. • No fear of contamination.

  12. Future of Edible Vaccine • Resistance to GM foods may affect future of Edible Vaccine.

  13. Limitation • Transgenic contamination can occur. • Antibiotic resistance marker genes can spread from GM food to pathogenic Bacteria. • Difficulty in dose maintenance.

  14. Conclusion • Edible plant derived vaccine may lead to a future of safer and more effective immunization.

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