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Sofosbuvir-Velpatasvir in Genotype 2 ASTRAL-2*

Phase 3. Treatment Naïve & Experienced. Sofosbuvir-Velpatasvir in Genotype 2 ASTRAL-2*. *Published in tandem with ASTRAL-3 Trial. Foster GR, et al. N Engl J Med. 2015 ;373:2608-17. Sofosbuvir-Velpatasvir in HCV Genotype 2 ASTRAL-2: Study Features.

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Sofosbuvir-Velpatasvir in Genotype 2 ASTRAL-2*

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  1. Phase 3 TreatmentNaïve & Experienced Sofosbuvir-Velpatasvir in Genotype 2ASTRAL-2* *Published in tandem with ASTRAL-3 Trial Foster GR, et al. N Engl J Med. 2015;373:2608-17.

  2. Sofosbuvir-Velpatasvir in HCV Genotype 2ASTRAL-2: Study Features Source: Foster GR, et al. N Engl J Med. 2015;373:2608-17.

  3. Sofosbuvir-Velpatasvir in HCV Genotype 2ASTRAL-2: Study Design 0 12 24 Week Treatment-naïve or experienced GT 2 (N=266) Sofosbuvir-Velpatasvir SVR12 N=134 Sofosbuvir + Ribavirin SVR12 N=132 *Randomization stratified by treatment experience and cirrhosis status. Abbreviations: SOF-VEL = sofosbuvir-velpatasvir; RBV = ribavirin Drug DosingSofosbuvir-velpatasvir (400/100 mg): fixed-dose combination; one pill once dailySofosbuvir: 400 mg once dailyRibavirin (weight-based and divided bid): 1000 mg/day if < 75 kg or 1200 mg/day if ≥ 75 kg Source: Foster GR, et al. N Engl J Med. 2015;373:2608-17.

  4. Sofosbuvir-Velpatasvir in HCV Genotype 2ASTRAL-2: Baseline Characteristics Source: Foster GR, et al. N Engl J Med. 2015;373:2608-17.

  5. Sofosbuvir-Velpatasvir in HCV Genotype 2ASTRAL-2: Results ASTRAL-2: SVR12 Results 133/134 124/132 P=0.018 for superiority of Sofosbuvir-Velpatasvir compared with Sofosbuvir + Ribavirin Source: Foster GR, et al. N Engl J Med. 2015;373:2608-17.

  6. Sofosbuvir-Velpatasvir in HCV Genotype 2ASTRAL-2: Results ASTRAL-2: SVR12 Results by Cirrhosis & Treatment Experience 99/100 92/96 15/15 14/15 15/15 13/16 4/4 4/4 Treatment Naïve Treatment-Experienced Source: Foster GR, et al. N Engl J Med. 2015;373:2608-17.

  7. Sofosbuvir-Velpatasvir in HCV Genotype 2ASTRAL-2: Adverse Events Source: Foster GR, et al. N Engl J Med. 2015;373:2608-17.

  8. Sofosbuvir-Velpatasvir in HCV Genotype 2ASTRAL-2: Conclusions Source: Foster GR, et al. N Engl J Med. 2015;373:2608-17.

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