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Cardiac Modeling of Steady-State Transients in the Ventricular Myocyte

Cardiac Modeling of Steady-State Transients in the Ventricular Myocyte. Raymond Tran University of Queensland July 3 2013 UCSD PRIME. Research Proposal. To expand the Shannon et al cardiac model and its limitations by accounting for change in intracellular potassium concentration.

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Cardiac Modeling of Steady-State Transients in the Ventricular Myocyte

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  1. Cardiac Modeling of Steady-State Transients in the Ventricular Myocyte Raymond Tran University of Queensland July 3 2013 UCSD PRIME

  2. Research Proposal • To expand the Shannon et al cardiac model and its limitations by accounting for change in intracellular potassium concentration. • Nimrod is a modeling system that conducts parametric sweep across multiple computing resources. • Specifically, Nimrod will be integrated with the model to look for steady-state values of AP, [Ca]i, [Na]i, [K]i. Nimrod

  3. Methods 1. Will first search for the steady-state transients by testing values of applied current and its duration in the cell. 2. Will also examine the parameters of the Na-K pump and its effect on AP and the change of intracellular Ca, Na, and K over time.

  4. Progress of Experiment • In the process of running first test experiment on Nimrod/G. • Will conduct parametric sweep of the applied current in the model. • Current objective is to run multiple experiments with different parameters to find steady-state transients.

  5. Brisbane, Queensland Left: The Brisbane Wheel, located in central Brisbane. Top right: Bridge at Indooroopilly, a small town approximately 6 kilometers from the university. Bottom Right: The Brisbane River.

  6. Acknowledgements University of California, San Diego • Dr. Anushka Michailova, Department of Bioengineering. • UCSD PRIME – Dr. Peter Arzberger, Dr. Gabriele Wienhausen, Ms. Teri Simas. University of Queensland • Dr. David Abramson, Centre for Research Computing • Hoang Nguyen, Ph.D. student at University of Queensland

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