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MATERNAL AND INFANTILE CHORIOCARCINOMA

Case report. MATERNAL AND INFANTILE CHORIOCARCINOMA. BS Lê Văn Tài BS Phan Thanh Hải BS Lê Hữu Linh Trung Tâm Y Khoa MEDIC. BỆNH ÁN. Bệnh nhân nữ 41 tuổi . Địa chỉ : Daklak , ĐT: 01645450937 Lâm sàng : Sau sanh đau ngực (P) lan ra sau lưng .

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MATERNAL AND INFANTILE CHORIOCARCINOMA

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  1. Case report MATERNAL AND INFANTILE CHORIOCARCINOMA BS LêVănTài BS Phan Thanh Hải BS LêHữu Linh TrungTâm Y Khoa MEDIC

  2. BỆNH ÁN • Bệnhnhânnữ 41 tuổi. • Địachỉ: Daklak, ĐT: 01645450937 • Lâmsàng: • Sau sanhđaungực (P) lanrasaulưng. • Khámcơxươngkhớpđượclàm MRI cộtsốngthấytổnthươngphổi, màngphổi Khám CK phổi, CT ngực: đanốt 2 phổivàtổnthươnghủycungsauxươngsườn IV (P)  Siêuâmbụng.

  3. BÀN LUẬN

  4. Choriocarcinoma is a rare malignant disease that arises from the trophoblastic cells of the placenta. It is characterized by secretion of human chorionic gonadotropin (β-hCG). • Maternal choriocarcinoma is extremely rare, occurring in an estimated 1 in 50,000 live births. • About 50 percent of cases of choriocarcinoma arise from complete hydatidiform mole, an additional 25 percent arise after normal pregnancies, and 25 percent follow spontaneous abortion or ectopic pregnancy.

  5. Infantile choriocarcinoma is even rarer. Less than 30 cases have been described in the literature. • Newborn infants tend to present with a characteristic clinical picture of anemia, hepatomegaly, and precocious puberty. Infantile choriocarcinoma occurs between 0 and 6 months of age. • Metastasis is common and usually affects liver, lung, brain, and skin, in that order. • Infantile cutaneous manifestation of the disease is extremely rare. Of 208 neonates between 1955 and 2010 with malignancies and cutaneous metastases, only 4 patients (1.9%) had cutaneous metastasis due to choriocarcinomaand it was generally associated with poor prognosis.

  6. Approximately one-quarter of infants with choriocarcinoma present with symptoms at birth and diagnosis can be easily confirmed with serum β-hCG. • These tumors are highly vascular and friable, so biopsy may be difficult and even dangerous. Anemia may be gradual or may result from tumor rupture. • Failure to thrive is nonspecific and may only manifest as feeding difficulties. • Hemoptysis and respiratory failure may be the primary manifestations of lung involvement. Brain and skin involvement are rarely seen and usually indicated advanced disease.

  7. Choriocarcinoma is a very aggressive malignancy and death may result from delays in diagnosis. Therefore, early intervention is critical for limiting the progression of disease. In infants, without appropriate treatment, death usually occurs within 3 weeks of initial presentation. • Fortunately, despite its aggressive nature, this cancer responds very well to chemotherapeutic agents, even in the presence of widespread metastases. The chance of long-term survival, even in patients with cerebral metastases at presentation, is approximately 80%.

  8. Because a history of maternal choriocarcinoma is associated with a risk of infantile choriocarcinoma in subsequent pregnancies, current guidelines suggest that women with such a history should be checked for β-hCG at 6 and 10 weeks following a subsequent pregnancy, regardless of the outcome.

  9. KẾT LUẬN • Choriocarcinomahiếm & di cănthainhicànghiếmhơn, cóthểxảyra ở thaikỳsinhnởbìnhthường. • β-hCGđặchiệutrongbệnhlýnầy. • Phụnữcóthai6 – 10 tuầnnênlàmβ-hCGnếuđãbịbệnhtrướcđây. • Bệnhdiễntiếnnhanh, dựhậuxấunếuđiềutrịtrễ. Tuynhiênbệnhđápứnghóatrịtốt.

  10. THANK YOU FOR YOUR ATTENTIONS

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