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HC Place cells

HC Place cells. taxi drivers enlarged CA1 region Rat place cells How was this diagram obtained? How reliable is it?. rat running in triangular path. McNaughton et al (1996) J Exp Biol 199 , 173–185. Colours represent different neurons. recordings separated by 1 hr in home cage

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HC Place cells

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  1. HC Place cells taxi drivers enlarged CA1 region Rat place cells How was this diagram obtained? How reliable is it? rat running in triangular path McNaughton et al (1996) J Exp Biol 199, 173–185

  2. Colours represent different neurons

  3. recordings separated by 1 hr in home cage recordings separated by 6 hours of novel environments

  4. The recording environment consisted of a moderately illuminated room, with a raised triangular track located in the middle. The rat’s task was to move continuously in one direction around the track to receive food reinforcement at the mid-point of each side

  5. Note this is actually a restrained rat, being gently moved around It all began… 400 ms O'Keefe J, Dostrovsky J. Brain Res. 1971 Nov;34(1):171-5. [on VLE]

  6. Multiple electrodes Use a computer to do spike recognition O'Keefe &. Recce (1993) Hippocampus 3, 317–330

  7. LEDs to track head position and direction Inbuilt FET amplifier, 14 x 4 Gothard et al (1996) J Neurosci: 16:823-835

  8. Freely moving rat O’Keefe (1976) Experimental neurol 51, 78-109 (1976)

  9. Place unit 202-2. There is a smaller high-frequency displace unit in the background O’Keefe (1976) Experimental neurol 51, 78-109 (1976)

  10. trained to forage in T-maze light, buzzer, fan, white card, O'Keefe Conway (1978) Exp. Brain Res. 31,573-590

  11. place cells [2 and 3] firing as rat ran along runway theta rhythm of EEG speed of rat O'Keefe &. Recce (1993) Hippocampus 3, 317–330

  12. Precession at end of rhythm at start of rhythm

  13. rats foraging over platform record CA1 pyramidal cells in theta θ rhythm Skaggs et al (1996) Hippocampus 6:149-172

  14. Place cells fire out of θphase where was the max firing of this pyramidal cell? where was rat when θ was max? Skaggs et al (1996) Hippocampus 6:149-172

  15. Review • Are the CA1 cells firing at random? • Are the CA1 neurons firing to • place • some other activity • motivation? http://biolpc22.york.ac.uk/750/mem/place_cells.ppt

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