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A New Look At Radiation Carcinogenesis IRPA -13 May 2012

A New Look At Radiation Carcinogenesis IRPA -13 May 2012. Prof. Otto G. Raabe Center for Health & the Environment University of California, Davis. Protracted Exposures To Ionizing Radiation. RADIATION INDUCED CANCER.

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A New Look At Radiation Carcinogenesis IRPA -13 May 2012

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  1. A New Look At Radiation CarcinogenesisIRPA -13 May 2012 Prof. Otto G. Raabe Center for Health & the Environment University of California, Davis

  2. Protracted ExposuresTo Ionizing Radiation

  3. RADIATION INDUCED CANCER • Cancer Induction depends of lifetime average dose rate to the target organ. • Cancer induction risk is not proportional to cumulative dose. • Low dose rates yield a life span virtual threshold (cumulative doses <10 Sv).

  4. Acute ExposuresTo Ionizing Radiation

  5. Atomic Bomb Survivor Studies • Radiation Effects Research Foundation,RERF • 79,972 survivors with calculated rad doses • 44,636 survivors with doses > 0.005 Sv Solid Cancer Incidence in Atomic Bomb Survivors: 1958-1998, Preston, Ron, Tokuoka, Funamoto, Nishi, Soda, Mabuchi, Kodama, Radiat. Res. 168, 1-64 (2007).

  6. A-Bomb Survivor Risk for 1 Gy Exposure • Age 5: 13%/80 y; Age 25: 9.5%/60 y; • Age 45: 6.5%/40 y. ALL = 0.16% per year

  7. CANCER INDUCTION IS NOT PROPORTIONAL TO DOSE • A-Bomb cancer promotion data for a very high dose-rate instantaneous exposure cannot be used to estimate cancer induction risk from protracted exposures to ionizing radiation. • Liner models to currently used by the International Commission on Radiological Protection and the U.S. Environmental Protection Agency are not valid.

  8. References • Raabe, OG: Concerning the Health Effects of Internally Deposited Radionuclides, Health Phys. 98: 515-536; 2010. • Raabe, OG: Toward Improved Ionizing Radiation Safety Standards, Health Phys. 101: 84 -93; 2011.

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