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HMGbox

A. b -catenin bd. HMGbox. TCF4. dnTCF4. N-TCF4. NLS. B. Ls174T N –TCF4. -. -. -. -. +. +. +. +. I. 2. -. -. +. +. Dox. N -TCF4. - Dox. +Dox. Top / Fop. 1. 2. C. N -TCF4. Tet-R. 1. 2. - Dox. Ls174T. + Dox. D. N -TCF4. 1. 2. - Dox. 68 %. 28 %. BrdU FITC.

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HMGbox

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  1. A b-catenin bd HMGbox TCF4 dnTCF4 N-TCF4 NLS B Ls174T N –TCF4 - - - - + + + + I 2 - - + + Dox N -TCF4 - Dox +Dox Top / Fop 1 2 C N -TCF4 Tet-R 1 2 - Dox Ls174T + Dox D N -TCF4 1 2 - Dox 68 % 28 % BrdU FITC 36 % 10 % + Dox Propidium Iodide Ls174T N -TCF4 E Down-regulated Up-regulated I 2 I 2 Dox MUC2 BMP-4 c-MYC CAII FABP-L EPHB3 p21CIP1/WAF1 NRP/B 28s 28s 18s 18s

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