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Premature Infant Outcomes. Linda Wallen, MD. Prevalence of Cerebral Palsy VLBW Infants - 1982-1994. Mortality Cerebral Palsy (% live births) (% survivors) 1982-1984 36.8 9.1 1984-1986 31.5 12.3 1986-1988 36.1 11.9 1988-1990 29.2 9.2 1990-1992 21.8 3.6 1992-1994 13.8 6.6.
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Premature Infant Outcomes Linda Wallen, MD
Prevalence of Cerebral Palsy VLBW Infants - 1982-1994 Mortality Cerebral Palsy (% live births) (% survivors) 1982-1984 36.8 9.1 1984-1986 31.5 12.3 1986-1988 36.1 11.9 1988-1990 29.2 9.2 1990-1992 21.8 3.6 1992-1994 13.8 6.6 (O’Shea et al., 1998)
Survival & Outcome of Infants Weighing <800 g 1979 to 1994 (O’Shea et al., Pediatrics 100: 982-986, 1997)
Survival & Outcome of Infants, 401-1250 g 1994 to 1996 (Finer et al., Pediatrics 104: 428-434, 1999)
Survival & Outcome of Infants, < 1250 g Doernbecher NCC, 1995 to 1998
Bayley Scales at 30 Months for Infants Born at < 26 Weeks Gestation Individual Scores on Bayley Scales at 30 months by Gestational Age (EPIcure Group (UK) follow up Mar-Dec 1995. New England J Med 343:381, 2000)
Adj. Risk for No Independent Walking Adj. Risk for No Independent Feeding Risk Factors for Cerebral Palsy in Infants < 1000 g at 18-22 Months From NICHD Network 1993-1994 Follow-Up. Pediatrics. 105:1221-22, 2000.
Adjusted Risk Factors for MDI < 70 Adjusted Risk Factors for PDI < 70 Risk Factors for Severe Developmental Delay in Infants <1000 g at 18-22 Months From NICHD Network 1993-1994 Follow-Up. Pediatrics. 105:1220-21, 2000.
30 Month Outcome for Infants Born at < 26 Weeks Died (2%) No data (1%) Severe disability (25%) No disability (49%) Other disability (25%) (EPIcure Group (UK) follow up Mar-Dec 1995. New England J Med 343:381, 2000)
NICHD Outcome of Infants 401-1000 g at Discharge From NICHD Network 1993-1994 Follow-Up. Pediatrics. 105:1221-22, 2000.
NICHD Outcome of Infants 401-1000 g at 18 Months From NICHD Network 1993-1994 Follow-Up. Pediatrics. 105:1221-22, 2000.
NICHD Outcome of Infants 401-1000 g at18 Months From NICHD Network 1993-1994 Follow-Up. Pediatrics. 105:1221-22, 2000.
Growth Failure in the ELBW Infant • Growth at 1 yr of infants 501-800 g born 1989-1994 • Head circumference < 10% = 35% (45/219) • Weight < 10% = 58% (75/219) • Length < 10% = 33% (42/219) • Growth at 6-7 yr of infants < 750 g born 1982-86 • Head circumference < 3% = 35% (24/68) • Weight < 3% = 22% (15/68) • Height < 3% = 25% (17/68) • Growth at 6-7 yr of infants 750-1499 g born 1982-86 • Head circumference < 3% = 14% (9/65) • Weight < 3% = 11% (7/65) • Height < 3% = 5% (3/65)
Outcomes of ELBW infants • Historical reasons for reliance on neurologic morbidities • Public misperception of prevalence of severe disability • Limitation of range of outcomes studied • Other health outcomes that are affected • Increased incidence of asthma • Increased visual perceptual & expressive language disabilities • Increased behavioral problems • Growth failure • Family and child perception of health and outcome • Psychological outcomes • Other factors which influence outcome = risk factors and post discharge environment, heavily influenced by maternal education, income level, smoking, poor maternal health (physical or mental)