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肿瘤免疫逃逸和生物调变分子机制的研究

国家自然科学奖汇报资料. 肿瘤免疫逃逸和生物调变分子机制的研究. 郭亚军（第二军医大学）. 肿瘤杀伤. 肿瘤发生发展转移. 肿瘤识别. 免疫调节. 肿瘤排斥. 研究背景. 肿瘤抗原 —— 性质与提呈 机体反应 —— 识别与排斥 免疫逃逸与转移 —— 粘附受体 免疫调节 —— 共刺激分子. 发现点之一. 肿瘤细胞存在肿瘤特异性 抗原 肿瘤特异性抗原的隐蔽是 由于其提呈功能的系统性缺失 肿瘤抗原提呈系统修复和重建的新理论. 细胞融合肿瘤抗原提呈模型. APC. 共刺激分子. MHC. 细胞融合. +. Tumor Vaccine.

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肿瘤免疫逃逸和生物调变分子机制的研究

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  1. 国家自然科学奖汇报资料 肿瘤免疫逃逸和生物调变分子机制的研究 郭亚军（第二军医大学）

  2. 肿瘤杀伤 肿瘤发生发展转移 肿瘤识别 免疫调节 肿瘤排斥

  3. 研究背景 • 肿瘤抗原——性质与提呈 • 机体反应——识别与排斥 • 免疫逃逸与转移——粘附受体 • 免疫调节——共刺激分子

  4. 发现点之一 • 肿瘤细胞存在肿瘤特异性抗原 • 肿瘤特异性抗原的隐蔽是由于其提呈功能的系统性缺失 • 肿瘤抗原提呈系统修复和重建的新理论

  5. 细胞融合肿瘤抗原提呈模型 APC 共刺激分子 MHC 细胞融合 + Tumor Vaccine Tumor cell cytokines

  6. MHC class I molecule Tumor antigen CD8+ T cell T-cell receptor Cytotoxic T cell APC Co-stimulatory molecule Fusion Tumor cell Receptor for co-stimulatory molecule CD8+ T cell CD4+ T cell MHC class II molecule cytokines

  7. 2000年《Nature Med》综述对本文的引用

  8. tumor T cell tumor T cell MHC-I TCR MHC-I TCR CD8 CD8 MHC-II MHC-II TCR TCR CD4 CD4 41BBL 41BB 41BBL 41BB B7 CD28 B7 CD28 ICAM-1 LFA-1 ICAM-1 LFA-1 bs-mAb Bridge tumor cell to T cells by bi-specific mAb greatly facilitate the interaction of adhesion molecular that costimulate T cell activation

  9. MHC-I The First Step Treatment of tumor cell in vitro with combination of cytokines to enhance tumor antigen proccessing and expression of adhesion molecule B7 MHC-II Tumor Cells ICAM-1 Tumor Cells Cytokines Treating

  10. Tumor Cells Tumor Cells + The Second Step Bi-specific mAb coating on the cytokine treated tumor cell surface

  11. Nature Medicine, 3(4) ：451- 455 PNAS, 101(14): 4990- 4995 Cancer Gene Therapy, 12: 769- 777

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