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Mesporin: Mepha Health Care.. for Post-operative Infection

Mesporin: Mepha Health Care.. for Post-operative Infection. Postoperative Infections, Simple Facts. The most common postoperative infections include: - Local infection: Surgical site (wound) infection, Intra-abdominal infection & abcess , - Remote infections:

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Mesporin: Mepha Health Care.. for Post-operative Infection

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  1. Mesporin:Mepha Health Care.. for Post-operative Infection The innovative Swiss pharmaceutical company

  2. Postoperative Infections,Simple Facts The innovative Swiss pharmaceutical company

  3. The most common postoperative infections include: - Local infection: • Surgical site (wound) infection, • Intra-abdominal infection & abcess, - Remote infections: • Respiratory tract infection, • Urinary tract infection, • The rates of surgical site and respiratory infections are less with laparoscopic surgery; however, in some studies laparoscopic surgery seems to cause a higher incidence of postoperative intra-abdominal abscess¹. 1: Boni et al; Infective Complications in Laparoscopic Surgery. Surgical Infections. Summer 2006, 7(supplement 2): s-109-s-111. The innovative Swiss pharmaceutical company

  4. Preventing Surgical Infections Antibiotic prophylaxis • Drugs: which, when, how many doses? Non antibiotic measures- evidence based: • Hair removal • Normothermia • Oxygen supplementation • Normoglycemia

  5. Antibiotic rationale –what should we choose? • Deal with the common pathogens encountered at the surgical site • One that is bactericidal • One that achieves adequate local soft tissue concentrations • One that is non toxic with minimal side effects • One that has a long serum half life • Ideally one that has a low risk of inducing resistance The innovative Swiss pharmaceutical company

  6. For such serious need in surgery… has developed an innovative antibiotic.. The innovative Swiss pharmaceutical company

  7. Ceftriaxone ProphylaxisGeneral & Gynecological Surgery The innovative Swiss pharmaceutical company

  8. Postsurgical infections varies in site, severity, & causative micro-organisms. • Therefore, 2 or 3 antibiotic combinations are usually used, as well as broad & ultra-broad spectrum antibiotic monotherapy. • To evaluate the role of surgical prophylaxis with ceftriaxone versus other antibiotics, a meta-analysis of 48 clinical studies were performed involving 17, 565 patients*. * Esposito et al; Ceftriaxone versus Other Antibiotics for Surgical Prophylaxis: A Meta-Analysis. Clinical Drug Investigation: 2004 - Volume 24 - Issue 1 - pp 29-39. The innovative Swiss pharmaceutical company

  9. Results: Incidence of postoperative infections The innovative Swiss pharmaceutical company

  10. Conclusions: • The meta-analysis showed that ceftriaxone is statistically superior to other antibiotics in preventing both local and remote postoperative infections. The innovative Swiss pharmaceutical company

  11. The antibiotic of choice Once daily therapy The innovative Swiss pharmaceutical company

  12. MesporinTM is a sterile, lyophilized, semi-synthetic, long-acting, parenteral (intravenous and intramuscular), broad-spectrum bactericidal antibiotic. The chemical formula of ceftriaxone sodium References: Zimmermanns M. Index Infektionen Erreger Antibiotika. 1989

  13. Properties and effects • The bactericidal activity of ceftriaxone results from inhibition of the • bacteria’s wall synthesis. • Ceftriaxone exerts activity against both Gram-negative and • Gram-positive aerobic and wide range of anaerobic microorganisms. • Ceftriaxone is highly stable to most β-lactamases, both penicillinases and • cephalosporinases, of Gram-negative and Gram-positive bacteria. References: Zimmermanns M. Index Infektionen Erreger Antibiotika. 1989

  14. Pharmacokinetics of ceftriaxone • Half-life of ceftriaxone is generally about 6 to 10 hours in • healthy adult subjects. • The exceptional pharmacokinetic characteristics of ceftriaxone • (MesporinTM) supports a once-daily dosing in every clinical • conditions and patient age. • A high plasma and tissue concentration after both i.v. and i.m. • administration simplifies the treatment and ensures an effective • bactericidal tissue concentration during 24 hours. References: Physician’s Desk Reference. 54th edition, 2000 Borgden R., Ward A. Drugs. 1988;35;604–645 Patel I. et al. Antimicrob Agents Chemother. 1981;20;634–641 Stoeckel et al. Current Chemotherapy and immunotherapy. 1982;Vol.1;454–455

  15. The antibiotic of choice • Compensatory excretion through the kidney and liver prevents accumulation in case of impairment of one or the other. • Dual and balanced excretion Via Renal and Biliary pathways The innovative Swiss pharmaceutical company

  16. Why Mesporin? ONCE DAILY TOP SWISS QUALITY Lyophilized ceftriaxone Deep tissue penetration Dual excretion pathways The innovative Swiss pharmaceutical company

  17. Thank You The innovative Swiss pharmaceutical company

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