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Session 5

Session 5. Case. Diagnosis - Sclerosing adenosis with lobular neoplasia. No invasion in images provided. Update - Risk with LISN. Meta-analysis 9 studies of 228 patients 15% ipsilateral, 9% contralateral carcinoma Ipsilateral 3x more likely than contralateral.

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Session 5

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  1. Session 5

  2. Case

  3. Diagnosis - Sclerosing adenosis with lobular neoplasia.No invasion in images provided.

  4. Update - Risk with LISN • Meta-analysis 9 studies of 228 patients • 15% ipsilateral, 9% contralateral carcinoma • Ipsilateral 3x more likely than contralateral • A “model of premalignancy for ALH intermediate between a local precursor and a generalised risk for both breasts” • Page DL. Lancet. 2003;361:125-9

  5. Is there a sub-group of pre-invasive LCIS? LCIS with Microinvasion • 6 LCIS with microinvasion described • Nemoto T et al. J Surg Oncol 1998; 67; 41-46

  6. Case 19

  7. Diagnosis - Fibrocystic change with papillomas and florid usual epithelial hyperplasia

  8. Case 32

  9. Diagnosis - Fibrocystic change with atypical lobular hyperplasia and flat high grade DCIS

  10. Case 54

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