Microbiology 204: Cellular and Molecular Immunology

1. Microbiology 204: Cellular and Molecular Immunology

2. Microbiology 204: Cellular and Molecular Immunology

8. T cells can promote the immune defense capabilities of other cells or directly kill virus-infected cells

9. Cytokines

10. Cytokine receptor families

11. Sentinel immune cells are equipped with innate immune receptors

12. TLR recognition leads to production of inducers of inflammation

13. Cytokines and Inflammation Macrophages or DCs stimulated via TLRs make pro-inflammatory cytokines, especially TNF (Tumor necrosis factor), IL-1, and IL-6 TNF and IL-1 signal to endothelial cells to make them: Leaky to fluid (influx of plasma; containing antibodies, complement components, etc.) Sticky for leukocytes, leading to influx of neutrophils first, then monocytes, lymphocytes IL-6 promotes adaptive immune responses and has systemic effects

15. Leukocyte recruitment to sites of inflammation

18. Immune sentinel cells in the tissues: dendritic cells With these mice in hand, we can achieve specific ablation of MyD88 in a cell-type specific way. As mentioned before, With these mice in hand, we can achieve specific ablation of MyD88 in a cell-type specific way. As mentioned before,

19. Dendritic cells pick up antigen in the tissues

20. Dendritic cells take up antigen and mature

22. Dendritic cells can take antigen to the draining lymph node to activate T cells

26. Molecular basis of adaptive immune recognition

27. Many different antigen receptors are created by combinations of gene segments

29. Monoclonal antibodies used in medicine

34. Use of monoclonal antibodies recognizing CD antigens by flow cytometry

35. Helper T cells can adopt different fates with different functions