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Ralph H. B. Benedict, PhD, ABPP-CN Professor of Neurology, Psychiatry and Psychology

Brains & Gains November 2013. Ralph H. B. Benedict, PhD, ABPP-CN Professor of Neurology, Psychiatry and Psychology University at Buffalo, SUNY.

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Ralph H. B. Benedict, PhD, ABPP-CN Professor of Neurology, Psychiatry and Psychology

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  1. Brains & Gains November 2013 Ralph H. B. Benedict, PhD, ABPP-CN Professor of Neurology, Psychiatry and Psychology University at Buffalo, SUNY

  2. [In] most of the patients affected by multi-locular sclerosis whom I have had occasion to observe … there is marked enfeeblement of the memory; conceptions are formed slowly; the intellectual and emotional faculties are blunted in their totality. The dominant feeling in the patients appears to be a sort of almost cheerful indifferencein reference to all things. Jean-Martin Charcot (1877)

  3. mesial temporal r = 0.42 [Sicotte 2008; Benedict 2009] 3rd ventricle r = 0.71 [Christodolou 2003; Benedict 2004] thalamus r = 0.75 [Houtchens 2007] cerebral cortex r = 0.65 [Amato 2004; Benedict 2006; Tekok-Kilic 2007] Demyelination and axonopathy

  4. Walking Upper Extremity Function Cognitive Ability Depression Job Loss Reduced work hours Demotion Less Salary Miss Promotion Negative Work Events Work Errors Forgetting Appointments Slow Work, Reduced Productivity Unequal Work Distribution Social Difficulty Employer Patient Coworker Accommodations/Intervention High Tech, Low Tech Aids Overt, Covert Aids Additional Time to Complete Tasks Flexible Schedule

  5. Cognitive Impairment Maintain Employment Mild Severe Private Disability Social Security Disability Early Retirement

  6. Hours Worked per Week Income Extra Time Spent Outside Work

  7. How to Monitor Clinical Status?

  8. www.BICAMS.net

  9. Why do some MS Patients Fare so Well? • Cognitive Reserve • Exercise • Personality • Cognitive Retraining

  10. Dimensional models of personality: the five-factor model and the DSM-5 Timothy J. Trull, PhD; Thomas A. Widiger, PhD. Dialogues ClinNeurosci. 2013;15:135-146.

  11. Conscientiousness p = 0.023 Neuroticism p = 0.001

  12. Adam J. Booth Jonathan D. Rodgers Carolyn E. Schwartz, Sc.D Brian R. Quaranto Bianca Weinstock-Guttman Robert Zivadinov Ralph H. B. Benedict Active Cognitive Reserve Influences the Regional Atrophy to Cognition Link in Multiple Sclerosis In Press

  13. Thank You Bianca Weinstock-Guttman MD Robert Zivadinov MD; Murali Ramanathan PhD David Hojnacki MD; Channa Kolb MD Margaret Bucello NP; Audrey Smerbeck PhD Jonathan Rodgers PhD, Natalie Emmert BA

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