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Transporter Screening

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Transporter Screening

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  1. 2020/10/8 Transporter Screening Assays Transporter Screening Assays - Creative BioMart Menu  Search for... Keywords search Transporter Screening Assays SERVICES Home / Services /Transporter Screening Assays Transporter Screening Assays Transporters and channels control the uptake and efflux of essential nutrients, ions, cellular waste and drugs into and out of cells and organelles. Transporters mediate drug disposition and are major determinants of the pharmacokinetic, safety and efficacy profiles of drugs. Recent studies have shown that the inhibition or activation of a specific transporter that involves in the absorption, disposition, metabolism, elimination and toxicity of a drug could have significant clinical effects ranging from lowering drug efficacy to compromising safety etc. Transporters are implicated in the pathophysiology of disorders across several therapeutic areas including asthma, cardiovascular disease, diabetes and neuroscience, and therefore, represent attractive targets for drug discovery. Drug transporters are composed of two major super families: ABC (ATP binding cassette) and SLC (solute carrier) transporters. https://www.creativebiomart.net/Transporter-Assay.htm 1/7

  2. 2020/10/8 Transporter Screening Assays - Creative BioMart Creative BioMart has been the leading provider of high quality transporter assay services. We use proprietary knowledge and technologies to overcome the challenges associated with transport assay development. These assays include state-of-the-art multi-vectorial transporter models and predictive modeling of complex molecular transport. We delivers consistent, high quality data with the flexibility to adapt protocols based on specific customer requirements. Technologies for Transporter Drug Discovery Fluorescence Radioactivity Electrophysiology Atomic absorption spectrophotometry (AAS) Mass spectrometry To expand the application of transporter biology, Creative BioMart has been constantly looking for innovative ways to meet your requirements in areas https://www.creativebiomart.net/Transporter-Assay.htm 2/7

  3. 2020/10/8 Transporter Screening Assays - Creative BioMart including pharmacokinetics, toxicology, therapeutic target discovery and basic research. Advantages of transporter screening with Creative BioMart: Provide functional characterization of compound activity High throughput functional assay Cover key drug transporters and neurotransmitter transporters Assays meet regulatory requirements Flexible project design Single ASBT, asc-1, ASCT2, BCRP, BSEP, CAT1, CNT1, Transporter CNT2, CNT3, DAT, EAAT1, EAAT2, EAAT3, ENT1, Assays ENT2, ENT4, GAT1, GAT2, GAT3, GLYT1b, Glyt2, MATE1, MATE2-K, MRP2, MRP4, NET1/NET, NTCP, OAT1, OAT2, OAT3, OAT4, OATP1A2, OATP1B1, OATP1B3, OATP2B1, OCT1, OCT2, OCT3, OCTN1, OCTN2, PEPT1, PEPT2, P-gp, SERT, SGLT2, SMVT, SNAT2, TAUT1, URAT1, xCT. Muti-Transporter Dual: OCT1/MATE1, OCT2/MATE1, OCT2/MATE2-K, Assays OATP1B1/MRP2, OATP1B1/BCRP, OATP1A2/MDR1, OATP1B3/BCRP, OATP1B3/MRP2, OATP1B3/MDR1. Triple: OATP1B1/NTCP/BSEP, OCT2/OCT3/MATE1, OCT2/MATE1/MATE2K, OCT2/MATE1/MATE2K. https://www.creativebiomart.net/Transporter-Assay.htm 3/7

  4. 2020/10/8 Transporter Screening Assays - Creative BioMart Quintuple: OAT2/OCT2/OCT3/MATE1/MATE2K. Reference: Adam Weinglass, Greg Kaczorowski and Maria Garcia. Technologies for transporter drug discovery. Channels 2008, 2:5, 312-321, DOI: 10.4161/chan.2.5.6896 Welcome to contact us or send an email to info@creative-biomart.com for project quotations and more detailed information. Online Inquiry Name: Your Name * Phone: Phone * E-mail Address: Email Address Organization: Organization * Service & Products of Interested: Transporter Screening Assays Project Description: https://www.creativebiomart.net/Transporter-Assay.htm 4/7

  5. 2020/10/8 Transporter Screening Assays - Creative BioMart Project Description * Verification code: Verification Code Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information SUBMIT 100 Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible. https://www.creativebiomart.net/Transporter-Assay.htm 5/7

  6. 2020/10/8 Transporter Screening Assays - Creative BioMart Apply For A Coupon $50 OFF YOUR FIRST PURCHASE APPLY FOR A COUPON https://www.creativebiomart.net/Transporter-Assay.htm 6/7

  7. 2020/10/8 Transporter Screening Assays - Creative BioMart ENTER YOUR EMAIL HERE TO SUBSCRIBE. you@email.com SUBMIT CREATIVE BIOMART INC.  USA: 45-1 Ramsey Road, Shirley, NY 11967, USA  Global Locations  USA: 1-631-559-9269 / 1-516-512-3133  Fax: 1-631-938-8127  Email: info@creative-biomart.com Easy access to products and services you need from our library via powerful searching tools.     Follow Us Copyright © 2007 – 2020 Creative BioMart. All Rights Reserved. Terms and Conditions | Privacy Policy https://www.creativebiomart.net/Transporter-Assay.htm 7/7

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