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Metabolism of nucleotides

Metabolism of nucleotides. Richard Vytášek 2011. Introduction. Structure of nucleobases, nucleosides and nucleotides Metabolic functions effected by nucleotides Dietetary uptake of nucleotides and their utilization. Biosynthesis of nucleotides.

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Metabolism of nucleotides

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  1. Metabolism of nucleotides Richard Vytášek 2011

  2. Introduction • Structure of nucleobases, nucleosides and nucleotides • Metabolic functions effected by nucleotides • Dietetary uptake of nucleotides and their utilization

  3. Biosynthesis of nucleotides • Biosynthesis of purine nucleotides de novo (PRPP -> IMP -> AMP, GMP) and its regulation • Purine salvage pathway (Lesch-Nyhan Syndrom) • Biosynthesis of pyrimidine nucleotides de novo and its regulation • Pyrimidine salvage pathway • Biosynthesis of deoxyribonucleotides • Biosynthesis of thymine nucleotides

  4. Catabolism of nucleotides and nucleobases • Degradation of nucleotides • Degradation of purine nucleotides • Gout • Degradation of pyrimidine nucleotides • Degradation of thymine

  5. Nucleoside analogues • antiviral agents (typically inhibitors of reverse transcriptase – e.g. azidothymidine ) • cytostatics (chemotherapy – e.g. cytosine arabinoside )

  6. Literature Harper´s Illustrated Biochemistry (2006) pp. 294-310

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