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Role for Hypocretin in Mediating Stress-Induced Reinstatement of Cocaine-Seeking Behavior

Hypocretin-1 and -2 (Hcrt-1

Antony
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Role for Hypocretin in Mediating Stress-Induced Reinstatement of Cocaine-Seeking Behavior

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    1. Role for Hypocretin in Mediating Stress-Induced Reinstatement of Cocaine-Seeking Behavior Investigating the effects of Hypocretin-1+2 (Hcrt-1 / Hcrt-2)? on reinstatement of drug seeking behavior through stress pathways

    2. Hypocretin-1 and -2 (Hcrt-1 & -2)? Recently discovered Lateral Hypothalmic Neuropeptides (1996) also known as Orexins 1+2 bind equally at Hcrt-R Projections Locus Ceruleus (Major) - NE Dorsal Raphe Nuclei - 5-HT Amygdala Suprachiasmatic Nucleus biological clock Basal Forebrain Cholinergic Brainstem Spinal Cord

    3. Hypocretin Evidence points to excitatory function ?energy expenditure, ?feeding behavior, ?locomotor activity. Evidence indicates that Hcrt neurons drive hyper-arousal through modulation of stress Stress? ?CRF? ?Hypocretin Role for Hcrt in reward seeking?

    4. Hypocretin (background) Foot shock (FS) and Restraint (RS) induce c-Fos expression in Hypocretin neurons Less so in neurons with CRF-R knockouts

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