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Carlo Basile Associazione Nefrologica Gabriella Sebastio, Martina Franca

Carlo Basile Associazione Nefrologica Gabriella Sebastio, Martina Franca. Ieri, oggi e domani. RICHARD BRIGHT, M.D.F.R.S. Physician Extraordinary to the Queen. SEZIONE SAGITTALE DI UN RENE. Corticale Midollare.

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Carlo Basile Associazione Nefrologica Gabriella Sebastio, Martina Franca

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  1. Carlo Basile Associazione Nefrologica Gabriella Sebastio, Martina Franca

  2. Ieri, oggi e domani RICHARD BRIGHT, M.D.F.R.S.Physician Extraordinary to the Queen

  3. SEZIONE SAGITTALE DI UN RENE Corticale Midollare In ogni rene vi è un milione di nefroni. I due reni contengono circa due milioni di nefroni che lavorano in parallelo Elementi di fisiologia renale

  4. Glomerulopatie genetiche

  5. Glomerulopatie genetiche

  6. … altri contributi della genetica …. Malattie cistiche renali genetiche

  7. Malattie cistiche renali genetiche

  8. Diagram of the PKD1 protein, polycystin-1 (left) and the PKD2 protein, polycystin-2, and their interaction through coiled-coil domains in the C-terminal tails (according to the revised molecular model) Torres V et al KI 2009

  9. The major autoantigen in membranous nephropathy is PLA2R. Autoantibodies to PLA2R are found in 70-80% of patients with membranous nephropathy • Measuring circulating anti-PLA2R antibodies could help to monitor disease activity in nephrotic patients with membranous nephropathy and guide personalized rituximab therapy

  10. In the field of bone and mineral disorders associated with chronic kidney disease, major insight has been gained into the fibroblast growth factor 23 (FGF23)-Klotho axis. It not only determines phosphate homeostasis but is also central to the clinical observation that chronic kidney disease is a state of accelerated ageing

  11. Enzyme replacement therapy has changed the natural history of Fabry disease, an X-linked disorder that results from a mutation in the gene that encodes the lysosomal hydrolase α-glactosidase Fabry disease is characterized by kidney failure, cerebrovascular manifestations, hearth failure, and eventually premature death

  12. Inhibiting the complement pathway with the anti-C5 monoclonal antibody eculizumab leads to rapid and sustained remission of hematologic and renal abnormalities and improved renal function in patients with atypical hemolytic uremic syndrome

  13. passato, presente e futuro Urinary proteomics

  14. Presente Current methods for assessing proteinuria

  15. Presente e Futuro Schema of translation of urinary proteomics into clinical practice Bramham, K. et al. QJM 2009 102:523-538

  16. Presente e Futuro 2009 QJM 2009 102(8):523-538 Recent developments in proteomic techniques promise exciting insight into normal renal physiology and renal disease processes, allowing precise definition of the disease proteome. In turn this will enable diagnosis, prognosis and prediction of response to treatment of individuals. …………………………………............…

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