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Most Admired Pharma And Biotech Visioneries Shaping the industies future,2024

In the heart of AstraZenecau2018s cutting-edge pharmaceutical research and development, Chad Kellner stands as the driving force behind transforming the future of healthcare by unlocking the power of what science can do, for people, society and the planet.<br>

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Most Admired Pharma And Biotech Visioneries Shaping the industies future,2024

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  1. VOL 02 I ISSUE 16 I 2024 Most Most Admired Admired Pharma & Pharma & BioTech BioTech Visionaries, Shaping Visionaries, Shaping theIndustry's theIndustry's Future-2024 Future-2024 Chad Kellner Head, Gaithersburg Site Operations A New Dawn AstraZeneca Could Regenera?ve Medicine Be the Key to Trea?ng Malignant Diseases? Medevolve The Applica?on of Stem Cell Therapy Architect of Growth Chad Kellner Chad Kellner Pioneering Tomorrow's Leaders Today

  2. The art of medicine consists in amusing the patient while nature cures the disease.

  3. The art of medicine consists in amusing the patient while nature cures the disease.

  4. Precision in Medicine and Beyond he pharmaceutical and biotech industries have 3D printing technology is being used to create seen a significant increase in innovation and personalized medical devices and implants, such as T technological advancements in recent years. prosthetics and dental implants, which can improve Precision medicine is an innovative approach to patient outcomes and reduce costs. Blockchain patient care that involves tailoring treatments to technology is being explored as a way to improve the individual patients based on their genetic makeup, efficiency and security of drug supply chains, clinical environment, and lifestyle. This approach allows for trials, and medical records. more targeted and personalized treatments, which can lead to better outcomes and reduced side effects. Overall, these innovations are driving significant advances in the pharmaceutical and biotech AI and ML are being used to revolutionize drug industries, with the potential to improve patient discovery and development by analyzing large outcomes, increase efficiency, and reduce costs. Some datasets and identifying potential drug candidates of the visionary leaders in the niche are utilizing these faster and more efficiently than traditional methods. trends and benchmarking excellence with core Moreover, Gene therapy is an emerging field that innovation. Spotlighting these gems of the pharma and involves using genetically engineered viruses to biotech niche, CIOLook showcases “Most Admired deliver therapeutic genes to patients. This approach Pharma & BioTech Visionaries, Shaping the Industry's has the potential to cure genetic diseases by replacing Future - 2024.” or repairing faulty genes. Flip through the pages and indulge in the odyssey of Digital health solutions, such as mobile apps and prolonged brilliance. Have a delightful read! wearables, are being developed to help patients manage their health conditions and provide healthcare providers with real-time data to make informed decisions. Editor's Anish Miller Note

  5. Precision in Medicine and Beyond he pharmaceutical and biotech industries have 3D printing technology is being used to create seen a significant increase in innovation and personalized medical devices and implants, such as T technological advancements in recent years. prosthetics and dental implants, which can improve Precision medicine is an innovative approach to patient outcomes and reduce costs. Blockchain patient care that involves tailoring treatments to technology is being explored as a way to improve the individual patients based on their genetic makeup, efficiency and security of drug supply chains, clinical environment, and lifestyle. This approach allows for trials, and medical records. more targeted and personalized treatments, which can lead to better outcomes and reduced side effects. Overall, these innovations are driving significant advances in the pharmaceutical and biotech AI and ML are being used to revolutionize drug industries, with the potential to improve patient discovery and development by analyzing large outcomes, increase efficiency, and reduce costs. Some datasets and identifying potential drug candidates of the visionary leaders in the niche are utilizing these faster and more efficiently than traditional methods. trends and benchmarking excellence with core Moreover, Gene therapy is an emerging field that innovation. Spotlighting these gems of the pharma and involves using genetically engineered viruses to biotech niche, CIOLook showcases “Most Admired deliver therapeutic genes to patients. This approach Pharma & BioTech Visionaries, Shaping the Industry's has the potential to cure genetic diseases by replacing Future - 2024.” or repairing faulty genes. Flip through the pages and indulge in the odyssey of Digital health solutions, such as mobile apps and prolonged brilliance. Have a delightful read! wearables, are being developed to help patients manage their health conditions and provide healthcare providers with real-time data to make informed decisions. Editor's Anish Miller Note

  6. C C O V 08 O E R Architect of Growth S N T Chad Kellner O Pioneering Tomorrow's Leaders Today R T Y E A New Dawn Could Regenera?ve Medicine 16 Be the Key to Trea?ng Malignant Diseases? N T Medevolve The Applica?on of Stem 20 Cell Therapy S

  7. C C O V 08 O E R Architect of Growth S N T Chad Kellner O Pioneering Tomorrow's Leaders Today R T Y E A New Dawn Could Regenera?ve Medicine 16 Be the Key to Trea?ng Malignant Diseases? N T Medevolve The Applica?on of Stem 20 Cell Therapy S

  8. Pooja M Bansal Editor-in-Chief CONTENT FOLLOW US ON Deputy Editor Anish Miller www.facebook.com/ciolook Managing Editor Katherine Debora www.twi?er.com/ciolook WE ARE ALSO AVAILABLE ON DESIGN Visualizer Dave Bates Art & Design Director Davis Mar?n CONTACT US ON Associate Designer Jameson Carl Email Featured Person Company Name Brief info@ciolook.com SALES For Subscrip?on Chad Kellner, Chad Kellner stands as the driving force behind transforming Senior Sales Manager Wilson T., Hunter D. AstraZeneca www.ciolook.com the future of healthcare by unlocking the power of what science Head, Gaithersburg astrazeneca.com can do, for people, society and the planet. Customer Success Manager David Stewart Site Operations Copyright © 2024 CIOLOOK, All rights reserved. The content and Sales Execu?vesTim, Smith images used in this magazine should Dr. Moses is true professional extremely passionate about not be reproduced or transmi?ed in Moses Enokela SonoCare Healthcare maternal mortality and is working hard on saving lives of TECHNICAL any form or by any means, Founder and CEO sonocare.com.ng women nationwide. electronic, mechanical, Technical Head Peter Hayden photocopying, recording or otherwise, without prior permission Technical Consultant Victor Collins Mr Qasim Bata, Founder and Director of PBL Care is a man of from CIOLOOK. many virtues, who practises the fundamental principles of PBL Care Qasim Bata Reprint rights remain solely with humanity and exhibits the characteristics of a true leader, pblcare.com CEO SME-SMO CIOLOOK. provides genuine care rather than monetary care. Research Analyst Eric Smith SEO Execu?veAlen Spencer Serge is a dynamic leader and team builder outstanding in Serge Bouteleau SIDUS S.A. operational management and process improvement Director sidus.com.ar sales@ciolook.com Uché founded Advancing Health Equity with the goal of Advancing Health Equity Uché Blackstock partnering with healthcare organizations and startups to address February, 2024 advancinghealthequity.com Founder & CEO the critical factors contributing to racial health inequities.

  9. Pooja M Bansal Editor-in-Chief CONTENT FOLLOW US ON Deputy Editor Anish Miller www.facebook.com/ciolook Managing Editor Katherine Debora www.twi?er.com/ciolook WE ARE ALSO AVAILABLE ON DESIGN Visualizer Dave Bates Art & Design Director Davis Mar?n CONTACT US ON Associate Designer Jameson Carl Email Featured Person Company Name Brief info@ciolook.com SALES For Subscrip?on Chad Kellner, Chad Kellner stands as the driving force behind transforming Senior Sales Manager Wilson T., Hunter D. AstraZeneca www.ciolook.com the future of healthcare by unlocking the power of what science Head, Gaithersburg astrazeneca.com can do, for people, society and the planet. Customer Success Manager David Stewart Site Operations Copyright © 2024 CIOLOOK, All rights reserved. The content and Sales Execu?vesTim, Smith images used in this magazine should Dr. Moses is true professional extremely passionate about not be reproduced or transmi?ed in Moses Enokela SonoCare Healthcare maternal mortality and is working hard on saving lives of TECHNICAL any form or by any means, Founder and CEO sonocare.com.ng women nationwide. electronic, mechanical, Technical Head Peter Hayden photocopying, recording or otherwise, without prior permission Technical Consultant Victor Collins Mr Qasim Bata, Founder and Director of PBL Care is a man of from CIOLOOK. many virtues, who practises the fundamental principles of PBL Care Qasim Bata Reprint rights remain solely with humanity and exhibits the characteristics of a true leader, pblcare.com CEO SME-SMO CIOLOOK. provides genuine care rather than monetary care. Research Analyst Eric Smith SEO Execu?veAlen Spencer Serge is a dynamic leader and team builder outstanding in Serge Bouteleau SIDUS S.A. operational management and process improvement Director sidus.com.ar sales@ciolook.com Uché founded Advancing Health Equity with the goal of Advancing Health Equity Uché Blackstock partnering with healthcare organizations and startups to address February, 2024 advancinghealthequity.com Founder & CEO the critical factors contributing to racial health inequities.

  10. Y Y R R O O I am a life-long “ learner and as T T such, I strive to create an insatiable desire S S for learning in every member of my team.” R R E E Architect of Growth V V O O Chad Kellner Chad Kellner Pioneering Tomorrow's Leaders Today C C

  11. Y Y R R O O I am a life-long “ learner and as T T such, I strive to create an insatiable desire S S for learning in every member of my team.” R R E E Architect of Growth V V O O Chad Kellner Chad Kellner Pioneering Tomorrow's Leaders Today C C

  12. n the heart of AstraZeneca's cutting-edge Chad has noticed a common trend among as process breakdowns allows us to foster a culture of pharmaceutical research and development, Chad professionals—a reluctance to acknowledge their lack innovation instead of finger-pointing. It's essential for I Kellner stands as the driving force behind of knowledge and an aversion to seeking help when maintaining a positive work environment.” transforming the future of healthcare by unlocking the needed. He points out, "This tendency often leads to power of what science can do, for people, society and confusion, missed deadlines, overspending, or falling short Reflecting on his team's growth, Chad believes in the planet. As the Head of Gaithersburg Site of expectations.” empowering his direct reports to expand their skills. He Operations, he manages and guides a diverse team of explains, "Encouraging my team to explore various roles engineers, scientists, finance experts, and compliance Chad believes that for businesses to stay ahead and within the business makes them more versatile." While it professionals. Together, they craft state-of-the-art remain innovative, it's crucial to let go of the outdated may pose short-term staffing challenges, it creates facilities that pave the way for groundbreaking notion of ‘job security.’ In today's business world, he well-rounded employees who bring diverse value to our biological research and development. emphasizes that success relies on close collaboration and team. coordination between different functions and departments. Chad's story is filled with remarkable achievements. In "The world has changed significantly and we need to adapt Chad's approach not only nurtures a culture of his previous roles, he steered teams through a period of accordingly," he says. continuous improvement but also fosters a dynamic remarkable growth, managing operational expenses and adaptable workforce ensuring long-term success and capital budgets amid an 80% surge in employee Shared Belief, Grand Achievements for the organization. numbers. His strategic prowess extended to overseeing a vast real estate portfolio and ensuring seamless Chad, reflecting on his early days as a project manager, Knowledge as Catalyst integration with the expanding workforce. Additionally, shares a valuable lesson he learned while overseeing his legacy includes pioneering the implementation of the implementation of an Enterprise Resource Chad is a dedicated lifelong learner and he believes in enterprise-wide resource maintenance planning and Management (ERM) system. He recalls, "I aimed to unify fostering a culture of continuous learning within his cutting-edge metrology & automation systems global locations on a single platform, creating a team. He shares, "I instill an insatiable desire for learning reshaping the industry's technological landscape. standardized workflow for all sites. The idea was grand but I in every member of my team by sharing insights from my missed a crucial element—building a team of early own experiences. I encourage them to explore various Amidst the pulsating energy of pharmaceutical adopters.” content sources.” innovation, his commitment to driving progress echoes in every facility delivered under his guidance. In the In Chad's experience, the absence of a supportive team realm of healthcare excellence, Chad stands as an ideal led to the failure of his ambitious plan. He admits, "I example of transformative leadership, illuminating the didn't focus on cultivating a group that believed in my vision path towards a future where science drives and the need for change. As a result, the grand vision was unprecedented healthcare advancements. scaled down significantly after the system went live.” Without fostering an Let’s explore the innovative solutions, groundbreaking Having worked on diverse projects throughout his research and state-of-the-art facilities led by Chad and his career, including mergers, acquisitions and ERM environment where the dedicated team! installations, Chad emphasizes the importance of team is engaged outside of “ “ having a team that shares your ambition and vision. He Innovation Through Collaboration asserts, "Regardless of the project's complexity, having a the business, in the team aligned with your goals significantly increases the industry and with One of the cornerstones of Chad’s management odds of success. Collaboration and shared belief can turn regulators, it is nearly philosophy is ensuring coordinated actions between his any challenging idea into a reality.” teams and the individuals on the teams. To lead a large, impossible to stay highly effective and high-functioning team, it is Lessons from Leadership compliant considering the essential that everyone understands what each member is responsible for, what each other is doing and Chad, with his pragmatic outlook, views challenges as pace of change most importantly, being comfortable asking for help. invaluable learning opportunities. He shares, "When throughout the mistakes occur, my focus is on extracting lessons from the biopharmaceutical Chad shares, “I believe that an effective organization is one incident rather than placing blame. It's all about continuous in which each member is comfortable enough to admit improvement.” industry.” when assistance is needed, or when clarification is required so that as a group, we can deliver the commitments that we In his approach to handling errors, Chad avoids creating make to our customers, colleagues and patients.” a punitive atmosphere. He states, "Considering mistakes

  13. n the heart of AstraZeneca's cutting-edge Chad has noticed a common trend among as process breakdowns allows us to foster a culture of pharmaceutical research and development, Chad professionals—a reluctance to acknowledge their lack innovation instead of finger-pointing. It's essential for I Kellner stands as the driving force behind of knowledge and an aversion to seeking help when maintaining a positive work environment.” transforming the future of healthcare by unlocking the needed. He points out, "This tendency often leads to power of what science can do, for people, society and confusion, missed deadlines, overspending, or falling short Reflecting on his team's growth, Chad believes in the planet. As the Head of Gaithersburg Site of expectations.” empowering his direct reports to expand their skills. He Operations, he manages and guides a diverse team of explains, "Encouraging my team to explore various roles engineers, scientists, finance experts, and compliance Chad believes that for businesses to stay ahead and within the business makes them more versatile." While it professionals. Together, they craft state-of-the-art remain innovative, it's crucial to let go of the outdated may pose short-term staffing challenges, it creates facilities that pave the way for groundbreaking notion of ‘job security.’ In today's business world, he well-rounded employees who bring diverse value to our biological research and development. emphasizes that success relies on close collaboration and team. coordination between different functions and departments. Chad's story is filled with remarkable achievements. In "The world has changed significantly and we need to adapt Chad's approach not only nurtures a culture of his previous roles, he steered teams through a period of accordingly," he says. continuous improvement but also fosters a dynamic remarkable growth, managing operational expenses and adaptable workforce ensuring long-term success and capital budgets amid an 80% surge in employee Shared Belief, Grand Achievements for the organization. numbers. His strategic prowess extended to overseeing a vast real estate portfolio and ensuring seamless Chad, reflecting on his early days as a project manager, Knowledge as Catalyst integration with the expanding workforce. Additionally, shares a valuable lesson he learned while overseeing his legacy includes pioneering the implementation of the implementation of an Enterprise Resource Chad is a dedicated lifelong learner and he believes in enterprise-wide resource maintenance planning and Management (ERM) system. He recalls, "I aimed to unify fostering a culture of continuous learning within his cutting-edge metrology & automation systems global locations on a single platform, creating a team. He shares, "I instill an insatiable desire for learning reshaping the industry's technological landscape. standardized workflow for all sites. The idea was grand but I in every member of my team by sharing insights from my missed a crucial element—building a team of early own experiences. I encourage them to explore various Amidst the pulsating energy of pharmaceutical adopters.” content sources.” innovation, his commitment to driving progress echoes in every facility delivered under his guidance. In the In Chad's experience, the absence of a supportive team realm of healthcare excellence, Chad stands as an ideal led to the failure of his ambitious plan. He admits, "I example of transformative leadership, illuminating the didn't focus on cultivating a group that believed in my vision path towards a future where science drives and the need for change. As a result, the grand vision was unprecedented healthcare advancements. scaled down significantly after the system went live.” Without fostering an Let’s explore the innovative solutions, groundbreaking Having worked on diverse projects throughout his research and state-of-the-art facilities led by Chad and his career, including mergers, acquisitions and ERM environment where the dedicated team! installations, Chad emphasizes the importance of team is engaged outside of “ “ having a team that shares your ambition and vision. He Innovation Through Collaboration asserts, "Regardless of the project's complexity, having a the business, in the team aligned with your goals significantly increases the industry and with One of the cornerstones of Chad’s management odds of success. Collaboration and shared belief can turn regulators, it is nearly philosophy is ensuring coordinated actions between his any challenging idea into a reality.” teams and the individuals on the teams. To lead a large, impossible to stay highly effective and high-functioning team, it is Lessons from Leadership compliant considering the essential that everyone understands what each member is responsible for, what each other is doing and Chad, with his pragmatic outlook, views challenges as pace of change most importantly, being comfortable asking for help. invaluable learning opportunities. He shares, "When throughout the mistakes occur, my focus is on extracting lessons from the biopharmaceutical Chad shares, “I believe that an effective organization is one incident rather than placing blame. It's all about continuous in which each member is comfortable enough to admit improvement.” industry.” when assistance is needed, or when clarification is required so that as a group, we can deliver the commitments that we In his approach to handling errors, Chad avoids creating make to our customers, colleagues and patients.” a punitive atmosphere. He states, "Considering mistakes

  14. Quarterly, Chad reaches out to his entire division, scratch. He recalls, "To navigate the The Power of Foresight updating them on accomplishments, concerns and the challenges, I assembled a team of early company's future direction. He adds, "I use this adopters, drawing from my past Chad is a forward-thinking strategist who always opportunity to reflect on impactful books or videos, setting experiences.” adopts a big-picture perspective and focuses on long- an example for my team. Leading by doing, not just saying, term outcomes. He explains, "Considering the future is resonates well with my direct reports.” During the project, Chad faced budget crucial, especially amid significant growth in our research constraints but remained focused on sector. I proposed relocating to a consolidated facility, a For Chad, every conversation, whether casual or showcasing its significant benefits. He move met with resistance due to past investments.” professional, is a learning opportunity. He emphasizes, explains, "I highlighted key project aspects "There's something to learn and share in every interaction, that brought about substantial, albeit Though challenging, Chad's proposal eventually gained be it with family, friends, or colleagues. Sharing these intangible, advantages." These traction. He recalls, "Once we demonstrated the long-term learnings within the organization creates a fertile ground improvements instilled confidence and financial gains and enhanced operational efficiencies, the for growth.” convenience among the leaders. project, once deemed unrealistic, became a reality." Strategic, long-term thinking can transform businesses, Chad encourages his team to dedicate time each day to Chad's keen listening skills played a provided the justification is solid. learning something new or expanding on their pivotal role. He notes, "I paid close interests. He believes that this proactive approach not attention to discussions, identifying Chad's story highlights the importance of foresight and only unlocks individual creativity but also enriches the common themes. This insight allowed us to strategic planning, showcasing how embracing change entire team and organization. "Creating this adjust our transformation priorities, with a clear vision can lead to transformative outcomes environment," Chad states, "unleashes the potential of aligning them with the company directors' for any business. individuals and fosters innovation within the team and, concerns.” ultimately, the organization as a whole.” The Key to Success Recently, Chad conducted a case study, Future-Proofing Finances presenting his findings at the Annual We live in the most dynamic and fast-paced world in International Society of Pharmaceutical history. Chad emphasizes the importance of his team Chad is an expert in budget management and he Engineers. He proudly states, "The study staying updated with regulations and technologies. He emphasizes the significance of aligning business showcased the success of our approach, believes that staying current is vital for delivering life- justifications with site and company growth. He states, highlighting not just the project's impact changing medicines and remaining ahead in the "Understanding how a project benefits the business in the but also its role in triggering a broader industry. long run helps me prioritize funding requests effectively.” cultural transformation within the organization.” To achieve this, Chad's team actively engages with the In Chad's experience, the constant influx of new needs industry. He explains, "We attend conferences, serve on and ideas necessitates careful consideration. He adds, Automation at its Apex industry boards, participate in discussions and even publish "My team and colleagues have learned to provide peer-reviewed articles." It's not just about internal justifications and answer questions without my input. Chad, overseeing a sprawling 1.4 million expertise—external engagement is key. Supporting the Teaching them the importance of long-term benefits has square feet biopharmaceutical facility, same, he says, "Without fostering an environment where been crucial.” emphasizes the importance of the team is engaged outside of the business, in the industry automated systems. He explains, "These and with regulators, it is nearly impossible to stay Chad believes that fostering a team's understanding of systems act like having 25,000 extra eyes compliant considering the pace of change throughout the the ‘big picture’ and long-term advantages is essential. and ears, allowing us to respond swiftly to biopharmaceutical industry.” He notes, "With time and intentionality, the team becomes critical issues that impact our mission of bringing life- capable of evaluating requests independently. This changing medicines to patients.” Chad believes that fostering this active involvement autonomy streamlines the process and ensures resources ensures compliance amidst the rapid changes in the are allocated where they truly matter.” Beyond their evident benefits, Chad reveals the hidden biopharmaceutical sector. His approach highlights the My approach is to look at advantages of these systems. He states, "We've utilized necessity of industry engagement for businesses to mistakes or errors as process Listening, Learning, Leading them to gather utilization and power consumption data. thrive in the current dynamic landscape. “ “ This information has been instrumental in enhancing our breakdowns, and in turn, Chad is a strategic thinker in facilities management. He operational efficiencies and reducing our carbon footprint. The Curious Mind focus on continuous shares his journey of transforming their business into a Additionally, it has played a crucial role in our space improvement.” fully integrated digital solution in 2017. It was a planning efforts, aligning with our growth projections.” Chad has always been a naturally curious person and comprehensive project, building everything from that has translated this curiosity throughout his entire

  15. Quarterly, Chad reaches out to his entire division, scratch. He recalls, "To navigate the The Power of Foresight updating them on accomplishments, concerns and the challenges, I assembled a team of early company's future direction. He adds, "I use this adopters, drawing from my past Chad is a forward-thinking strategist who always opportunity to reflect on impactful books or videos, setting experiences.” adopts a big-picture perspective and focuses on long- an example for my team. Leading by doing, not just saying, term outcomes. He explains, "Considering the future is resonates well with my direct reports.” During the project, Chad faced budget crucial, especially amid significant growth in our research constraints but remained focused on sector. I proposed relocating to a consolidated facility, a For Chad, every conversation, whether casual or showcasing its significant benefits. He move met with resistance due to past investments.” professional, is a learning opportunity. He emphasizes, explains, "I highlighted key project aspects "There's something to learn and share in every interaction, that brought about substantial, albeit Though challenging, Chad's proposal eventually gained be it with family, friends, or colleagues. Sharing these intangible, advantages." These traction. He recalls, "Once we demonstrated the long-term learnings within the organization creates a fertile ground improvements instilled confidence and financial gains and enhanced operational efficiencies, the for growth.” convenience among the leaders. project, once deemed unrealistic, became a reality." Strategic, long-term thinking can transform businesses, Chad encourages his team to dedicate time each day to Chad's keen listening skills played a provided the justification is solid. learning something new or expanding on their pivotal role. He notes, "I paid close interests. He believes that this proactive approach not attention to discussions, identifying Chad's story highlights the importance of foresight and only unlocks individual creativity but also enriches the common themes. This insight allowed us to strategic planning, showcasing how embracing change entire team and organization. "Creating this adjust our transformation priorities, with a clear vision can lead to transformative outcomes environment," Chad states, "unleashes the potential of aligning them with the company directors' for any business. individuals and fosters innovation within the team and, concerns.” ultimately, the organization as a whole.” The Key to Success Recently, Chad conducted a case study, Future-Proofing Finances presenting his findings at the Annual We live in the most dynamic and fast-paced world in International Society of Pharmaceutical history. Chad emphasizes the importance of his team Chad is an expert in budget management and he Engineers. He proudly states, "The study staying updated with regulations and technologies. He emphasizes the significance of aligning business showcased the success of our approach, believes that staying current is vital for delivering life- justifications with site and company growth. He states, highlighting not just the project's impact changing medicines and remaining ahead in the "Understanding how a project benefits the business in the but also its role in triggering a broader industry. long run helps me prioritize funding requests effectively.” cultural transformation within the organization.” To achieve this, Chad's team actively engages with the In Chad's experience, the constant influx of new needs industry. He explains, "We attend conferences, serve on and ideas necessitates careful consideration. He adds, Automation at its Apex industry boards, participate in discussions and even publish "My team and colleagues have learned to provide peer-reviewed articles." It's not just about internal justifications and answer questions without my input. Chad, overseeing a sprawling 1.4 million expertise—external engagement is key. Supporting the Teaching them the importance of long-term benefits has square feet biopharmaceutical facility, same, he says, "Without fostering an environment where been crucial.” emphasizes the importance of the team is engaged outside of the business, in the industry automated systems. He explains, "These and with regulators, it is nearly impossible to stay Chad believes that fostering a team's understanding of systems act like having 25,000 extra eyes compliant considering the pace of change throughout the the ‘big picture’ and long-term advantages is essential. and ears, allowing us to respond swiftly to biopharmaceutical industry.” He notes, "With time and intentionality, the team becomes critical issues that impact our mission of bringing life- capable of evaluating requests independently. This changing medicines to patients.” Chad believes that fostering this active involvement autonomy streamlines the process and ensures resources ensures compliance amidst the rapid changes in the are allocated where they truly matter.” Beyond their evident benefits, Chad reveals the hidden biopharmaceutical sector. His approach highlights the My approach is to look at advantages of these systems. He states, "We've utilized necessity of industry engagement for businesses to mistakes or errors as process Listening, Learning, Leading them to gather utilization and power consumption data. thrive in the current dynamic landscape. “ “ This information has been instrumental in enhancing our breakdowns, and in turn, Chad is a strategic thinker in facilities management. He operational efficiencies and reducing our carbon footprint. The Curious Mind focus on continuous shares his journey of transforming their business into a Additionally, it has played a crucial role in our space improvement.” fully integrated digital solution in 2017. It was a planning efforts, aligning with our growth projections.” Chad has always been a naturally curious person and comprehensive project, building everything from that has translated this curiosity throughout his entire

  16. Daily Growth, Lasting Impact Chad’s advice to emerging leaders is—always seek to be a better version of yourself every day. Often upon completion of a project or task, lessons-learned exercises are conducted. People who are looking to continually improve don’t wait for the lessons learned activities, they debrief themselves every day and look People who are looking for ways to improve. to continually improve to improve.”“ “ According to Chad, “You must be willing to challenge your don’t wait for the own ways of working, seek difficult feedback and make lessons learned meaningful changes. This not only boosts your career but also keeps your personal growth on track.” But it isn’t activities, they debrief about solely focusing on one’s career. to themselves every An individual's personal journey must improve daily as day and look for ways well otherwise it gets out of sync and one can begin to falter. Chad underscores the significance of a supportive network, stating, "Surround yourself with trusted advisors who offer honest insights. Meeting regularly provides critical insights to make adjustments to your approach, strategy and tactics that are required to compete in today's market .The guidance I have received from my network has been invaluable throughout my journey." Chad also shares, "I have a group of trusted advisors, from very diverse industries, that I meet with weekly. life both personally and professionally. He reminisces, “I We have a round robin format with an intentionally remember my dad buying me a book when I was six or designed agenda, that fosters advice and counsel on seven years old called ‘The Way Things Work’. He told me personal and professional matters. Our overarching to read and then ask questions. The lesson he taught me purpose is to solicit unbiased and constructive then was—if you are curious about a topic, then go learn feedback, holding each other accountable to our more about it.” This early wisdom stayed with Chad. As individual goals and objectives.” he progresses in his career, Chad is cognizant of emerging technologies, how they are being deployed Chad's wisdom highlights the power of continuous self- and what their primary and marginal purposes are. reflection, openness to feedback and building a Additionally, Chad also remains aware of what is supportive network can serve as a guiding light for happening inside the business and what his network individuals aiming to enhance both their personal and outside of the business thinking about. He shares, “If professional lives. something in those discussion piques my curiosity, I’ll go learn more about it and if possible relate it back to my professional journey, if not, that is fine too.” Chad's approach underscores the value of curiosity, emphasizing its role in continuous learning and professional growth. He is a living reminder for everyone to embrace their inquisitive nature, driving them to explore new horizons in both their personal and business lives.

  17. Daily Growth, Lasting Impact Chad’s advice to emerging leaders is—always seek to be a better version of yourself every day. Often upon completion of a project or task, lessons-learned exercises are conducted. People who are looking to continually improve don’t wait for the lessons learned activities, they debrief themselves every day and look People who are looking for ways to improve. to continually improve to improve.”“ “ According to Chad, “You must be willing to challenge your don’t wait for the own ways of working, seek difficult feedback and make lessons learned meaningful changes. This not only boosts your career but also keeps your personal growth on track.” But it isn’t activities, they debrief about solely focusing on one’s career. to themselves every An individual's personal journey must improve daily as day and look for ways well otherwise it gets out of sync and one can begin to falter. Chad underscores the significance of a supportive network, stating, "Surround yourself with trusted advisors who offer honest insights. Meeting regularly provides critical insights to make adjustments to your approach, strategy and tactics that are required to compete in today's market .The guidance I have received from my network has been invaluable throughout my journey." Chad also shares, "I have a group of trusted advisors, from very diverse industries, that I meet with weekly. life both personally and professionally. He reminisces, “I We have a round robin format with an intentionally remember my dad buying me a book when I was six or designed agenda, that fosters advice and counsel on seven years old called ‘The Way Things Work’. He told me personal and professional matters. Our overarching to read and then ask questions. The lesson he taught me purpose is to solicit unbiased and constructive then was—if you are curious about a topic, then go learn feedback, holding each other accountable to our more about it.” This early wisdom stayed with Chad. As individual goals and objectives.” he progresses in his career, Chad is cognizant of emerging technologies, how they are being deployed Chad's wisdom highlights the power of continuous self- and what their primary and marginal purposes are. reflection, openness to feedback and building a Additionally, Chad also remains aware of what is supportive network can serve as a guiding light for happening inside the business and what his network individuals aiming to enhance both their personal and outside of the business thinking about. He shares, “If professional lives. something in those discussion piques my curiosity, I’ll go learn more about it and if possible relate it back to my professional journey, if not, that is fine too.” Chad's approach underscores the value of curiosity, emphasizing its role in continuous learning and professional growth. He is a living reminder for everyone to embrace their inquisitive nature, driving them to explore new horizons in both their personal and business lives.

  18. A New Dawn Could Regenerative Medicine Be the Key to Treating Malignant Diseases? T “ he Regenerative medicine evolution is upon us. Like iron and steel to the industrial revolution, like the microchip to the tech revolution, stem cells will be the driving force for this next revolution.” – Cade Hildreth The insufficient results from the traditional therapies in malignant diseases, like cancer treatment, have led to therapy resistance and cancer recurrence. Over the past decades, accumulating discoveries about stem cell biology have provided new potential approaches to cure cancer. Stem cells possess unique biological actions, including self-renewal, directional migration, differentiation, and modulatory effects on other cells, which can be utilized as regenerative medicine, therapeutic carriers, drug targeting, and generation of immune cells. Regenerative medicine involving the stem cell therapy, covers stem cells, has provided a hope in the fight against cancer. It can improve the therapeutic efficacy of other therapies due to its enhanced target on the malignant tumours lowering the effect on other areas. Numerous stem cell strategies are investigated in clinical research and have shown promising development in cancer treatment. Catalytic paradigm shift Stem cells from different sources exhibit different capacities of proliferation, migration, and differentiation, which determine their application in anti-tumour therapy. The Hematopoietic Stem Cells which are mature adult cells in bone marrow are derived from cord blood. This is currently the single methodology of stem cells which is approved by the FDA in the treatment of malignant diseases of multiple myeloma, leukaemia, and some kinds of blood system disorders. 16 17 www.ciolook.com | February 2024 | www.ciolook.com | February2024 |

  19. A New Dawn Could Regenerative Medicine Be the Key to Treating Malignant Diseases? T “ he Regenerative medicine evolution is upon us. Like iron and steel to the industrial revolution, like the microchip to the tech revolution, stem cells will be the driving force for this next revolution.” – Cade Hildreth The insufficient results from the traditional therapies in malignant diseases, like cancer treatment, have led to therapy resistance and cancer recurrence. Over the past decades, accumulating discoveries about stem cell biology have provided new potential approaches to cure cancer. Stem cells possess unique biological actions, including self-renewal, directional migration, differentiation, and modulatory effects on other cells, which can be utilized as regenerative medicine, therapeutic carriers, drug targeting, and generation of immune cells. Regenerative medicine involving the stem cell therapy, covers stem cells, has provided a hope in the fight against cancer. It can improve the therapeutic efficacy of other therapies due to its enhanced target on the malignant tumours lowering the effect on other areas. Numerous stem cell strategies are investigated in clinical research and have shown promising development in cancer treatment. Catalytic paradigm shift Stem cells from different sources exhibit different capacities of proliferation, migration, and differentiation, which determine their application in anti-tumour therapy. The Hematopoietic Stem Cells which are mature adult cells in bone marrow are derived from cord blood. This is currently the single methodology of stem cells which is approved by the FDA in the treatment of malignant diseases of multiple myeloma, leukaemia, and some kinds of blood system disorders. 16 17 www.ciolook.com | February 2024 | www.ciolook.com | February2024 |

  20. Mesenchymal Stem Cells possess unique biological Various strategies have been developed for cancer properties and are widely used to support other treatment using stem cell therapy, including HSC Empowerment through technology therapies or to deliver therapeutic agents in treating a transplantation, MSC infusion for post-cancer variety of cancers. treatment, stem cells for therapeutic carriers, defines the essence of Digital Healthcare Leadership generation of immune effector cells, and vaccine Whereas the Neural Stem Cells locatedin the central production nervous system, possess the ability to self-renew and generate new neurons and glial cells. They are tested to HSC Transplantation method treat both primary and metastatic breast, lung, and prostate cancers in murine models. The transplantation of Hematopoietic Stem Cells is used as a standard procedure for the treatment of The Cancer Stem Cells or immature parent versions of multiple myeloma, leukaemia, and lymphomas after tumour cells are generated by epigenetic mutations in rounds of high-dose radiotherapy or chemotherapy. normal stem cells. These cells are found within tumour The methodology is recently widely researched in tissues, playing important part in cancer growth, preclinical, clinical trials, in conjunction with metastasis, and recurrence. So, targeting these cancer immunotherapy or chemotherapy, in the treatment of stem cells can provide a promising hope in treating various different cancers such as breast cancer, various types of solid tumours. sarcomas, neuroblastoma and complex brain tumours. Starting From The Bone Marrow MSC Transplantation method post cancer treatments The Hematopoietic Stem Cells are formed in the bone Chemotherapy and Radiation treatments of aggressive marrow. However, during the process of chemotherapy cancers involves invasive tumour removal and high- cycles, the blood forming cells get greatly damaged as dose therapy leading to damage in normal tissues and well. In such situations, the patients are given hematopoietic system. It has revealed the infusion of intravenous injections of autologous hematopoietic mesenchymal stem cells helps in maintaining the stem cells. This initiates the returning of the cells undifferentiated state and proliferation of HSCs, leading to the rapid migration into specific stem cell thereby noticeably improving the output of the pockets. Upon entering the bone marrow, the treatment. MSCs with immunomodulatory effects transplanted stem cells undergo the settlement and could effectively reduce strong immune responses in become functional promoting the growth of new patients with refractory GVHD. Recent clinical trials special blood cells. have shown promising results with no adverse effects after the co-transplantation of MSCs and HSCs. One Tumour Tropic Effect ongoing multi-centre trial is testing the safety, tolerability, and efficacy of mesenchymoangioblast- The tumour cell environment, where extracellular derived MSC infusion in adults who have steroid- matrix and secreted paracrine factors are deposited, resistance. MSCs are also found to facilitate the defines tumour growth and invasion. This is done by recovery of injured organs and can enable body attracting the unidirectional migration of various types tolerance to high-dose chemotherapy to improve of cells, for example, Mesenchymal Stem Cells, the tumour-removing effects. endothelial cells and infiltrating immune cells. Tumours are considered chronic wound tissue with sustained Though the progress made in the clinical research of hypoxia, inflammation, and oxidative stress events, the regenerative medicine has taken a giant leap in the can’t heal. Hence, the migration of cells toward tumour direction of discovering the possible cures, yet the microenvironment is supposed to be like their research has a long way to go in the complete and migration to injured or ischemic sites. Both tumour cells effective treatment of the malignant monsters. and tumour-associated immune cells can involve this process through the secretion of various chemically induced factors. 18 www.ciolook.com | February 2024 |

  21. Mesenchymal Stem Cells possess unique biological Various strategies have been developed for cancer properties and are widely used to support other treatment using stem cell therapy, including HSC Empowerment through technology therapies or to deliver therapeutic agents in treating a transplantation, MSC infusion for post-cancer variety of cancers. treatment, stem cells for therapeutic carriers, defines the essence of Digital Healthcare Leadership generation of immune effector cells, and vaccine Whereas the Neural Stem Cells locatedin the central production nervous system, possess the ability to self-renew and generate new neurons and glial cells. They are tested to HSC Transplantation method treat both primary and metastatic breast, lung, and prostate cancers in murine models. The transplantation of Hematopoietic Stem Cells is used as a standard procedure for the treatment of The Cancer Stem Cells or immature parent versions of multiple myeloma, leukaemia, and lymphomas after tumour cells are generated by epigenetic mutations in rounds of high-dose radiotherapy or chemotherapy. normal stem cells. These cells are found within tumour The methodology is recently widely researched in tissues, playing important part in cancer growth, preclinical, clinical trials, in conjunction with metastasis, and recurrence. So, targeting these cancer immunotherapy or chemotherapy, in the treatment of stem cells can provide a promising hope in treating various different cancers such as breast cancer, various types of solid tumours. sarcomas, neuroblastoma and complex brain tumours. Starting From The Bone Marrow MSC Transplantation method post cancer treatments The Hematopoietic Stem Cells are formed in the bone Chemotherapy and Radiation treatments of aggressive marrow. However, during the process of chemotherapy cancers involves invasive tumour removal and high- cycles, the blood forming cells get greatly damaged as dose therapy leading to damage in normal tissues and well. In such situations, the patients are given hematopoietic system. It has revealed the infusion of intravenous injections of autologous hematopoietic mesenchymal stem cells helps in maintaining the stem cells. This initiates the returning of the cells undifferentiated state and proliferation of HSCs, leading to the rapid migration into specific stem cell thereby noticeably improving the output of the pockets. Upon entering the bone marrow, the treatment. MSCs with immunomodulatory effects transplanted stem cells undergo the settlement and could effectively reduce strong immune responses in become functional promoting the growth of new patients with refractory GVHD. Recent clinical trials special blood cells. have shown promising results with no adverse effects after the co-transplantation of MSCs and HSCs. One Tumour Tropic Effect ongoing multi-centre trial is testing the safety, tolerability, and efficacy of mesenchymoangioblast- The tumour cell environment, where extracellular derived MSC infusion in adults who have steroid- matrix and secreted paracrine factors are deposited, resistance. MSCs are also found to facilitate the defines tumour growth and invasion. This is done by recovery of injured organs and can enable body attracting the unidirectional migration of various types tolerance to high-dose chemotherapy to improve of cells, for example, Mesenchymal Stem Cells, the tumour-removing effects. endothelial cells and infiltrating immune cells. Tumours are considered chronic wound tissue with sustained Though the progress made in the clinical research of hypoxia, inflammation, and oxidative stress events, the regenerative medicine has taken a giant leap in the can’t heal. Hence, the migration of cells toward tumour direction of discovering the possible cures, yet the microenvironment is supposed to be like their research has a long way to go in the complete and migration to injured or ischemic sites. Both tumour cells effective treatment of the malignant monsters. and tumour-associated immune cells can involve this process through the secretion of various chemically induced factors. 18 www.ciolook.com | February 2024 |

  22. Medevolve The Application of Stem Cell Therapy “ ell therapies are rapidly emerging as potentially curative, individualized treatments for many of the C world’s most challenging diseases.” - Alain Vertes, Director of the EU section of the Alliance for Regenerative Medicine and managing director of NxR Biotechnologies. Rightly quoted, the importance of the smallest unit, the cell, is phenomenal. Stem cells are the basic category of cells found in humans and animals which have the ability to divide and develop into cells with specific functions. Stem cells can be considered as the basic raw resource from which other new cells with specific qualities can be generated. Under the right ecosystem in the human body or in a conducive lab environment, stem cells divide into newer cells, also termed daughter cells. Sources of stem cells Stem cells are common everywhere in our body, primarily found in our blood, bone marrow, brain, skin, heart, liver tissues and muscles. Stem cells originate from two main sources: adult body tissues and embryos. Generally, these stem cells lie dormant unless and until they are required to regenerate any damaged or lost tissue. Applications Scientists are also working on ways to develop stem cells from other cells, using genetic “reprogramming” techniques. Stem cell therapy has numerous applications in the treatment of certain diseases and complex health disorders. There is extensive research being conducted worldwide in leveraging their qualities to regenerate for customization of alternative and effective cures. 20 21 www.ciolook.com | February 2024 | www.ciolook.com | February 2024 |

  23. Medevolve The Application of Stem Cell Therapy “ ell therapies are rapidly emerging as potentially curative, individualized treatments for many of the C world’s most challenging diseases.” - Alain Vertes, Director of the EU section of the Alliance for Regenerative Medicine and managing director of NxR Biotechnologies. Rightly quoted, the importance of the smallest unit, the cell, is phenomenal. Stem cells are the basic category of cells found in humans and animals which have the ability to divide and develop into cells with specific functions. Stem cells can be considered as the basic raw resource from which other new cells with specific qualities can be generated. Under the right ecosystem in the human body or in a conducive lab environment, stem cells divide into newer cells, also termed daughter cells. Sources of stem cells Stem cells are common everywhere in our body, primarily found in our blood, bone marrow, brain, skin, heart, liver tissues and muscles. Stem cells originate from two main sources: adult body tissues and embryos. Generally, these stem cells lie dormant unless and until they are required to regenerate any damaged or lost tissue. Applications Scientists are also working on ways to develop stem cells from other cells, using genetic “reprogramming” techniques. Stem cell therapy has numerous applications in the treatment of certain diseases and complex health disorders. There is extensive research being conducted worldwide in leveraging their qualities to regenerate for customization of alternative and effective cures. 20 21 www.ciolook.com | February 2024 | www.ciolook.com | February 2024 |

  24. Ÿ Treatment of Ocular disorders More clinical trials based on larger sample people need to be carried out to investigate the relevance of stem The inability to complete recovery of visual function cell therapy, including its safety and efficacy, in and complications that follow in the conventional translational infertility medicine. treatments have shifted the search for a new form of therapy using stem cells. Stem cells play a major role in Ÿ Stem Cells Aiding the Treatment in Cardiovascular rebuilding the degenerated cells despite being present Diseases in low quantity and their state of dormancy in the body. Unlike other tissues and cells, regeneration of new Blood flow or the blood pressure gets altered due to optic cells responsible for visual function is rarely the scar tissue formation when the heart tissue gets observed. Understanding the transcription factors and deprived of oxygen. The stem cells obtained from the genes responsible for optic cells development will assist bone marrow are used for repairing the damaged heart scientists in formulating a strategy to activate and and blood vessels. direct stem cells renewal and differentiation. Ÿ Helping in Orthopedic treatments Stem cell-based therapy holds an extraordinary prospective in improving the lives of people who suffer Patients experiencing who are experiencing discomfort from visual disorders. Research in this area will because of various orthopaedic conditions, sports- continue to grow to develop new remedies for treating related injuries, or spinal issues. and preventing the problem of vision loss. It carries a promising future in producing new biological elements Ÿ Control and treatment of auto-immune diseases used to treat vision loss. For the patients living with conditions like lupus and Ÿ Stem Cell Therapy Applications in Clinical rheumatoid arthritis, application of stem cell therapy Research for autoimmune diseases is a relatively newer option. In the autoimmune diseases where the immune system Advancements in stem cell therapy continue to shed attacks its own organs, tissues, and cells, this therapy light on how stem cells may be used in various clinical helps to minimize the downtime that the patients have applications, which include cell replacement therapies, to deal with and it being minimally invasive. This proves immunomodulatory therapies, etc. to be a big advantage for patients who do not opt for the surgery. Ÿ Stem Cell Therapy in Fertility Treatments Ÿ Healing complex Incisions and Wounds Stem cells are now increasingly being tested as promising alternative therapies in translational Various types of research in stem cell application have research of regenerative medicine. Exciting progress successfully led to the regeneration of the local cells, has been made to understand the biology and function improving the growth of new healthy skin tissues, of stem cells. Looking at the minimum ethical concern stimulating new hair development after some odd with easy availability of resources, extensive research is injuries, and enhancing collagen production. It has being conducted. contributed to the rapid recovery in its function in substitution of the scar tissue with new healthy tissue. Induced Pluripotent Stem Cells or IPSC and Catalyzing care through Catalyzing care through Mesenchymal Stem Cells or MSC are researched for The Journey Ahead… their potential application in reproductive medicine, especially in cases of infertility resulting from The research in stem cell applications is noticed to digital innovation: the mark digital innovation: the mark azoospermia and premature ovarian insufficiency. reach new levels of identifying cures to the otherwise tough options for the current therapies, which is a great Evolutionary divergence observed in pluripotency relief. Though a lot more needs to be done, we can among animals and humans requires caution when certainly hope for the fact that stem cell therapy will of healthcare leaders. of healthcare leaders. concluding the data obtained from murine models to play an important pivotal role in transforming the safely apply them to clinical applications in humans. recovery and control of multiple health disorders. 22 www.ciolook.com | February 2024 |

  25. Ÿ Treatment of Ocular disorders More clinical trials based on larger sample people need to be carried out to investigate the relevance of stem The inability to complete recovery of visual function cell therapy, including its safety and efficacy, in and complications that follow in the conventional translational infertility medicine. treatments have shifted the search for a new form of therapy using stem cells. Stem cells play a major role in Ÿ Stem Cells Aiding the Treatment in Cardiovascular rebuilding the degenerated cells despite being present Diseases in low quantity and their state of dormancy in the body. Unlike other tissues and cells, regeneration of new Blood flow or the blood pressure gets altered due to optic cells responsible for visual function is rarely the scar tissue formation when the heart tissue gets observed. Understanding the transcription factors and deprived of oxygen. The stem cells obtained from the genes responsible for optic cells development will assist bone marrow are used for repairing the damaged heart scientists in formulating a strategy to activate and and blood vessels. direct stem cells renewal and differentiation. Ÿ Helping in Orthopedic treatments Stem cell-based therapy holds an extraordinary prospective in improving the lives of people who suffer Patients experiencing who are experiencing discomfort from visual disorders. Research in this area will because of various orthopaedic conditions, sports- continue to grow to develop new remedies for treating related injuries, or spinal issues. and preventing the problem of vision loss. It carries a promising future in producing new biological elements Ÿ Control and treatment of auto-immune diseases used to treat vision loss. For the patients living with conditions like lupus and Ÿ Stem Cell Therapy Applications in Clinical rheumatoid arthritis, application of stem cell therapy Research for autoimmune diseases is a relatively newer option. In the autoimmune diseases where the immune system Advancements in stem cell therapy continue to shed attacks its own organs, tissues, and cells, this therapy light on how stem cells may be used in various clinical helps to minimize the downtime that the patients have applications, which include cell replacement therapies, to deal with and it being minimally invasive. This proves immunomodulatory therapies, etc. to be a big advantage for patients who do not opt for the surgery. Ÿ Stem Cell Therapy in Fertility Treatments Ÿ Healing complex Incisions and Wounds Stem cells are now increasingly being tested as promising alternative therapies in translational Various types of research in stem cell application have research of regenerative medicine. Exciting progress successfully led to the regeneration of the local cells, has been made to understand the biology and function improving the growth of new healthy skin tissues, of stem cells. Looking at the minimum ethical concern stimulating new hair development after some odd with easy availability of resources, extensive research is injuries, and enhancing collagen production. It has being conducted. contributed to the rapid recovery in its function in substitution of the scar tissue with new healthy tissue. Induced Pluripotent Stem Cells or IPSC and Catalyzing care through Catalyzing care through Mesenchymal Stem Cells or MSC are researched for The Journey Ahead… their potential application in reproductive medicine, especially in cases of infertility resulting from The research in stem cell applications is noticed to digital innovation: the mark digital innovation: the mark azoospermia and premature ovarian insufficiency. reach new levels of identifying cures to the otherwise tough options for the current therapies, which is a great Evolutionary divergence observed in pluripotency relief. Though a lot more needs to be done, we can among animals and humans requires caution when certainly hope for the fact that stem cell therapy will of healthcare leaders. of healthcare leaders. concluding the data obtained from murine models to play an important pivotal role in transforming the safely apply them to clinical applications in humans. recovery and control of multiple health disorders. 22 www.ciolook.com | February 2024 |

  26. Medicine is a science of uncertainty and an art of probability

  27. Medicine is a science of uncertainty and an art of probability

  28. www.ciolook.com

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