Persistent Epithelial Defect (PED) Market

1. Persistent Epithelial Defect (PED) Market Persistent Epithelial Disease, also known as persistent corneal epithelial defects (PEDs or PCEDs), results from the failure of rapid re-epithelialization and closure within 10–14 days after a corneal injury, even with standard supportive treatment. PED is defined as “defects persisting for more than 2 weeks without improvement despite conventional treatment, such as non-preservative artificial tears or extended wear soft contact lenses”. DelveInsight’s‘Persistent Epithelial Defect (PED) - Market Insights, Epidemiology, and Market Forecast - 2030’ report delivers an in-depth understanding of the Persistent Epithelial Defect (PED), historical and forecasted epidemiology as well as the market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan. The Persistent Epithelial Defect (PED) market report provides current treatment practices, emerging drugs and their market share of the individual therapies, current and forecasted PED symptoms market Size from 2017 to 2030 segmented by seven major markets. The Report also covers current Persistent Epithelial Defect (PED) symptoms treatment practice/algorithm, market drivers, market barriers and unmet medical needs to curate the best of the opportunities and assesses the underlying potential of the market. Geographies Covered    The United States EU5 (Germany, France, Italy, Spain, and the United Kingdom) Japan Study Period: 2017–2030 Request for request/persistent-corneal-epithelial-defects-market sample pages: https://www.delveinsight.com/sample-

2. Persistent Epithelial Defect (PED) Disease Understanding and Treatment Algorithm Persistent Epithelial Defect (PED) Overview Persistent Epithelial Disease, also known as persistent corneal epithelial defects (PEDs or PCEDs), results from the failure of rapid re-epithelialization and closure within 10–14 days after a corneal injury, even with standard supportive treatment. PED is defined as “defects persisting for more than 2 weeks without improvement despite conventional treatment, such as non-preservative artificial tears or extended wear soft contact lenses”. PEDs commonly extend into the stromal layer, causing stromal melting, secondary ulceration, and stromal scarring. Also, an insult to the cornea resulting in an acute epithelial defect is a lesion that usually heals over the 7–14 days’ time frame. In contrast, a persistent epithelial defect is unable to close within this normal interval. The normal corneal wound healing process can be disrupted from defective epithelial adhesion, limbal stem cell deficiency, surface trauma, medications, infections, and several other etiologies. Such defects are especially common in individuals with metaherpes, neurotrophic keratopathy, or diabetic keratopathy. Some of the symptoms of PEDs are loss of corneal epithelial cells, delayed epithelialization post-injury, nonhealing epithelial defect and others which can be commonly due to Epithelial/limbal, inflammatory disease, Neurotrophic, mechanical causes, and others. Evaluating a PED involves instillation of fluorescein to monitor the size, location, and depth of the defect. A thorough physical exam should reveal findings such as inflammation in the anterior chamber, eyelid abnormalities, or decreased sensation of the cornea. Although several therapies exist and an increasing number of novel approaches are emerging, treatment of PEDs can still be quite challenging. It is important to treat the underlying causative condition, which may include infection, limbal stem cell deficiency, or diabetes, to facilitate wound healing. Furthermore, standard treatments, such as bandage contact lenses (BCLs) and artificial tears (ATs), aim to provide barrier protection to the epithelial layers. Persistent Epithelial Defect (PED) Diagnosis and Treatment It covers the details of conventional and current medical therapies and diagnosis available in the Persistent Epithelial Defect (PED) market for the treatment of the condition. It also provides the country-wise treatment guidelines and algorithms across the United States, Europe, and Japan. The DelveInsight Persistent Epithelial Defect (PED) market report gives a thorough understanding of PED symptoms by including details such as disease definition, symptoms, causes, pathophysiology, and diagnosis. It also provides PED symptoms of treatment algorithms and treatment guidelines for PED symptoms in the US, Europe, and Japan. Persistent Epithelial Defect (PED) Epidemiology The Persistent Epithelial Defect symptoms epidemiology division provides insights about the historical and current patient pool along with the forecasted trend for every seven major countries. It helps to recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders. This part of the DelveInsight report also provides the diagnosed patient pool and their trends along with assumptions undertaken. Key Findings The disease epidemiology covered in the report provides historical as well as forecasted Persistent Epithelial Defect (PED) epidemiology segmented as the Total Incident cases of Persistent epithelial defect, Etiology-specific cases of Persistent Epithelial Defect (PED). The report includes the Incident scenario of PED symptoms in 7MM covering the United States, EU5 countries (Germany, France, Italy, Spain, and the United Kingdom), and Japan from 2017 to 2030. Country Wise- Persistent Epithelial Defect (PED) Epidemiology

3. The epidemiology segment also provides the Persistent Epithelial Defect (PED) epidemiology data and findings across the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom) and Japan. The total Incident population of Persistent Epithelial Defect (PED) in 7MM countries was estimated to be 238,058 cases in 2017. Download sample pages: request/persistent-corneal-epithelial-defects-market Persistent Epithelial Defect (PED) Drug Chapters The drug chapter segment of the Persistent Epithelial Defect (PED) report encloses the detailed analysis of PED marketed drugs and late stage (Phase-III and Phase-II) pipeline drugs. It also helps to understand the Persistent Epithelial Defect (PED) clinical trial details, expressive pharmacological action, agreements and collaborations, approval and patent details, advantages and disadvantages of each included drug and the latest news and press releases. The therapeutic market size of PED in the US is mainly accounted for treatment options, such as approved therapy i.e Oxervate and off-label therapies such as lubricants, punctal occlusion, bandage contact lens, topical antibiotics, steroids and others. Amniotic membrane grafting, autologous serum, scleral contact lenses, have been recommended for the treatment of refractory cases. Products detail in the report… Persistent Epithelial Defect (PED) Emerging Drugs Nexagon: OcuNexus Therapeutics, Eyevance Pharmaceuticals It a first-in-class natural, antisense therapy that downregulates the cell membrane hemichannel forming protein, connexin43 (Cx43). Targeting the gap junctions may prevent immune system responses that may lead to inflammatory cascade and promote the microvasculature and regeneration of corneal epithelium. Nexagon has a market advantage in the US, as it received orphan drug designation from the FDA. It is being developed by OcuNexus Therapeutics in partnership with Eyevance Pharmaceuticals. Currently, the drug is under phase II studies for PED. Products detail in the report… Persistent Epithelial Defect (PED) Market Outlook The Persistent Epithelial Defect (PED) market outlook of the report helps to build the detailed comprehension of the historic, current and forecasted Persistent Epithelial Defect (PED) market trends by analyzing the impact of current therapies on the market, unmet needs, drivers and barriers and demand of better technology. This segment gives a thorough detail of Persistent Epithelial Defect (PED) market trend of each marketed drug and late-stage pipeline therapy by evaluating their impact based on annual cost of therapy, inclusion and exclusion criteria’s, mechanism of action, compliance rate, growing need of the market, increasing patient pool, covered patient segment, expected launch year, competition with other therapies, brand value, their impact on the market and view of the key opinion leaders. The calculated market data are presented with relevant tables and graphs to give a clear view of the market at first sight. According to DelveInsight, Persistent Epithelial Defect (PED) market in 7MM is expected to change in the study period 2017–2030. The first step in the management of any epithelial abnormality is to determine the etiology of the disease. Currently, “bandage” methods are used to help re-epithelialize a cornea. The current approaches include Aggressive lubrication, Punctal occlusion, Bandage soft contact lens, Pressure patching, Tetracyclines, prophylactic topical antibiotics and steroids. For the treatment of refractory cases, Amniotic membrane grafting, autologous serum, Scleral contact lenses, and others have recommended. In severe cases, a conjunctival graft may be placed over the cornea. https://www.delveinsight.com/sample-

4. Key Findings This section includes a glimpse of the Persistent Epithelial Defect (PED) market in 7MM. The market size of PED in the seven major markets was found to be USD 179.1 million in 2017. The United States Market Outlook This section provides the total Persistent Epithelial Defect (PED) market size and market size by therapies in the United States. The United States accounts for the highest market size of PED in comparison to the EU5 (the United Kingdom, Germany, Italy, France, and Spain) and Japan. Aggressive lubrication is typically the first-line therapy with either high-frequency application of preservative- free artificial tears or sterile ophthalmic ointment. This may prove to be particularly difficult with the noncompliant patient. Punctal occlusion may increase epithelial contact time with lubricating tears and ointments, and patients may benefit from temporary or permanent occlusion of the punctual. However, this is not recommended in the circumstances requiring the continued use of toxic agents. If the response to the previous measures is inadequate or for refractory cases, therapies such as Amniotic membrane grafting, autologous serum are the choice. Autologous serum drops have been reported to be beneficial in the treatment of persistent epithelial defect recalcitrant to conventional therapy. Along with this, Oxervate – first-ever recombinant human nerve growth factor indicated for the treatment of neurotrophic keratitis recently, which is one of the underlying etiologies for PED, thus may help some of the PED patients. Also, Dompé Farmaceutici may have the chance to expand its indication to PED with observed results in the future. It is the first-ever topical biologic medication approved in ophthalmology and has given a boost to a similar type of researches. EU-5 Countries: Market Outlook The total Persistent Epithelial Defect (PED) market size and market size by therapies in Germany, France, Italy, Spain, and the United Kingdom are provided in this section. if the etiology of the PED is due to the deficiency of the stem cells that are responsible for repopulating the epithelium, then Limbal stem cell transplantation (surgical replacement with stem cell (allo or autografts) is indicated. This is frequently seen in conditions such as ocular cicatricial pemphigoid, Stevens–Johnson syndrome, and severe alkali burns and others. Moreover, Scleral contact lenses, including the prosthetic replacement of the ocular surface ecosystem (PROSE) lens, may be utilized for refractory persistent epithelial defects. One recent treatment alternative is the topical use of Regenerating Agent Eye Drops (RGTAs). RGTA (OTR4120 (Cacicol20); laboratories Théa,) is a carboxymethyl dextran sulfate polymer bioengineered to replace heparan sulfate, which is an important factor both for matrix proteins and for growth factors. It is available in Europe as a novel therapeutic approach to treat PED patients, that are resistant to conventional therapy. Japan Market Outlook The total Persistent Epithelial Defect (PED) market size and market size by therapies in Japan are also mentioned. Click request/persistent-corneal-epithelial-defects-market here for sample pages: https://www.delveinsight.com/sample-