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What are the causes, risk factors, and treatment options for chronic myeloid leu

Chronic Myeloid Leukemia (CML) primarily affects adults and is rare in children. It involves the excessive proliferation of immature white blood cells, or granulocytes, within the bone marrow. These immature cells proliferate in the bone marrow and bloodstream, disrupting the production of other blood components such as red blood cells, white blood cells, and platelets. Fortunately, with advanced treatment options, CML is now manageable, offering favorable prognoses. It's important to note that CML is not genetically inherited from parents. Seeking expertise from hematologist specialists in De

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What are the causes, risk factors, and treatment options for chronic myeloid leu

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  1. BEST BMT Dr.Pawan Kumar Singh Dr Pawan Kumar Singh Dr Pawan Kumar Singh has the experience of performing more than 500 bone marrow transplants (including Autologous /Allogenic /Haplo /MDU )for both malignant and non-malignant disorders. www.bestbmt.com

  2. Content Topic for Discussion Chronic Myeloid Leukemia 01 Stages OF CML 02 Risk Factors Of CML 03 Treatment options for CML 04

  3. INTRODUCTION Chronic Myeloid Leukemia (CML) primarily affects adults and is rare in children. It involves the excessive proliferation of immature white blood cells, or granulocytes, within the bone marrow. These immature cells proliferate in the bone marrow and bloodstream, disrupting the production of other blood components such as red blood cells, white blood cells, and platelets. advanced treatment options, manageable, offering favorable prognoses. It's important to note that CML is not genetically inherited from parents. Seeking expertise from hematologist specialists comprehensive and effective management of CML. Fortunately, CML with now is in Delhi ensures

  4. Stages OF Chronic Myeloid Leukemia Chronic Phase: 1. Chronic Phase: This initial stage of CML typically manifests with minimal or no noticeable symptoms. At this juncture, only a small percentage (around 10%) of blast cells are detected in the bone marrow.

  5. Accelerated Phase Accelerated Phase: As the disease progresses, the number of myeloblasts increases to approximately 20% abnormalities may emerge. Symptoms begin to surface during this phase, signaling the progression of the disease. and additional Blastic Phase Blastic Phase: In the advanced stage of CML, myeloblasts outnumber normal blood cells (RBCs, WBCs, and platelets), exceeding the 20% threshold. Symptoms become more pronounced and severe, including spleen enlargement, susceptibility infections, bleeding tendencies, and significant weight loss accompanied by weakness. to severe

  6. Risk Factors Of Chronic Myelogenous Leukemia 1 Genetic Abnormalities: Specific genetic mutations, notably chromosome resulting from chromosomal translocation, heighten the susceptibility to CML. the Philadelphia 2 Radiation Exposure: Prolonged exposure to ionizing radiation, prevalent in radiation therapy or nuclear accidents, elevates the risk of CML development.

  7. 3 Age: While CML may manifest at any age, it predominantly affects adults, with the likelihood increasing, notably after 60 years. 4 Gender Disparity: Men exhibit a marginally higher predisposition to CML compared to women. 5 Family History: While CML isn't typically hereditary, individuals with a familial history of CML or other blood cancers may face an escalated risk.

  8. Chronic Myeloid Leukemia Causes 1 Radiation Exposure: Common among atomic bomb survivors or those heavily exposed to radiation, CML can develop in patients treated with high radiation doses for other cancers. Notably, exposure from routine dental and full-body scans is generally safe contribute to CML. and does not

  9. Chronic Myeloid Leukemia Causes 2 Mutation in Stem Cells: A pivotal cause involves the exchange between chromosomes 9 and 22, leading to the creation of the chromosome. This genetic abnormality is prevalent in CML patients and originates in abnormal blood cells' stem cells. Philadelphia

  10. Treatment options for Chronic Myeloid Leukemia Myeloid Leukemia Treatment options for Chronic Tyrosine Kinase Inhibitors (TKIs): Representing the frontline treatment, TKIs like imatinib, dasatinib, and nilotinib target the BCR-ABL protein generated by the Philadelphia chromosome. effectively control CML progression and are typically the initial therapeutic choice. These drugs Clinical Trials: Participation in clinical trials presents an opportunity for patients, particularly those with refractory or advanced CML, to explore novel therapies and treatment modalities. These trials assess experimental approaches enhancing treatment outcomes and elevating the quality of life for individuals grappling with CML. aimed at

  11. Chemotherapy: Although less commonly utilized than TKIs, chemotherapy may be employed in specific scenarios, particularly in advanced CML or when alternative treatment options are exhausted. Chemotherapeutic agents target rapidly dividing cells, including cancerous cells, to impede disease progression. Supportive Care: Beyond active treatments, hematologist specialists supportive care to alleviate symptoms, forestall complications, and bolster overall well-being. Supportive measures may encompass blood transfusions, prophylactic antibiotics to combat infections, and medications to mitigate treatment- related side effects. in Delhi prioritize

  12. Thank You! 09:00 AM - 05:00 PM +91-9354700860/ 8750637212

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