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Imbruvica 140mg | Imbruvica 140mg capsules | Ibrutinib 140mg | Ibrutinib 140mg capsules

Imbruvica stops a protein in B cells called Brutonu2019s tyrosine kinase, or BTK. BTK indicating <br>is required for B cells to multiply and survive.

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Imbruvica 140mg | Imbruvica 140mg capsules | Ibrutinib 140mg | Ibrutinib 140mg capsules

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  1. Imbruvica 140mg capsules Apple pharmaceuticals

  2. Imbruvica 140mg capsules • IMBRUVICA stops a protein in B cells called Bruton’s tyrosine kinase, or BTK. BTK indicating is required for B cells to multiply and survive.  • Imbruvica140mg may help progress abnormal B cells out of their nourishing environments in the lymph nodes, bone marrow, and other organs. 

  3. INDICATION • Mantle cell lymphoma (MCL) who have getting at least one prior treatment •  Chronic lymphocytic leukaemia (CLL)/Small lymphocytic lymphoma (SLL) • • Marginal zone lymphoma (MZL) who getting a medicine by mouth or injection (systemic therapy) and have getting a certain type of before treatment

  4. • Chronic graft versus host disease (cGVHD) after failure of 1 or more lines of systemic therapy • Waldenströmmacroglobulinemia (WM) • • Chronic graft versus host disease (cGVHD) after failure of 1 or more lines of systemic therapy •  Marginal zone lymphoma (MZL) who getting a medicine by mouth or injection 

  5. ADME • Peak plasma concentration of Imbruvica is 1-2 hours and drug taking with food will increasesibrutinibexposure. • Imbruvica has plasma protein level is 97.3% and Vd is 10,000L • Ibrutinib was excretion through feces 80% and urine 10 % Half-life of ibrutinib is 4-6 hours

  6. DOSAGE Lymphoma: • The recommended dose of patient is 420mg (three 140mg capsules) per oral qday • While in combination with bendamustine and rituximab the usual dose is 420mg PO qDay administrated q28d for up to 6 cycles until progression or undesirable toxicity

  7. Mantle Cell Lymphoma: • The recommended dose of patientis 560mg (four 140mg-mg capsules) PO qDay. • Follow until disease progression or undesirable toxicity • Marginal Zone Lymphoma : • The recommended dose of patientis 560mg (four 140mg-mg capsules) PO qDay. • Follow until disease progression or undesirable toxicity

  8. WaldenströmMacroglobulinemia: • The recommended dose of patient is 420mg (three 140mg capsules) per oral qDay • When combination with rituximab is 420 mg PO qDay plus rituximab administered weekly for 4 consecutive weeks (weeks 1-4)  • continued by a second course of weekly rituximab for 4 consecutive weeks (weeks 17-20)

  9. MECHANISM • Ibrutinib 140mg belongs to type of small-molecule inhibitor of BTK. Ibrutinib forms a covalent bond with a cysteine residue in the BTK active site, leading to inhibition of BTK enzymatic activity. •  Nonclinical studies revealwhichibrutinib prohibits malignant B-cell multiplication and survival in vivo as well as cell migration and substrate adhesion in vitro.

  10. PRECAUTION • Other malignancies (5-14%) resulted contains carcinomas (1-3%); the most frequent second primary malignancy was nonmelanoma skin cancer (4-11%)  • Tumor lysis syndrome intermittentlyresulted; assess the baseline risk (eg, high tumor burden) and take suitable precautions  • Based on findings in animals, can cause fetal risk when administered to a pregnant woman 

  11. DRUG INTERACTION • When Co administration of imbruvica 140mg with strong or moderate CYP3A inhibitor will increase ibrutinib plasma concentrations along with have high risk of drug related toxicity • When Co administration ofimbruvica 140mg with strong or moderate CYP3A inducers will decreaseibrutinib plasma concentrations.

  12. CONTRAINDICATION • Hypersentivityreaction MISSED DOSE • If dose is missed, thereby missed dose should be avoid and follow the regular dosing schedule. • Patients must consult with medical practitioner and follow the instructions given by them.

  13. SIDE EFFECTS More common side effects of Imbruvica 140mg : • Low platelets • Musculoskeletal pain • Swelling • Upper respiratory tract infection • Nausea • Diarrhea • Reduced neutrophils • Decreased haemoglobin • Fatigue • Bruising. 

  14. More common side effects of Imbruvica 140mg : • Skin infections • Asthenia • Muscle spasms • Shortness of breath • Constipation • Rash • Sinusitis • Headache • Dehydration • Dyspepsia • Abdominal pain • Vomiting • Decreased appetite

  15. CONTACT USphone No      : 9987711567Email             : Info@myapplepharma.comWEBSITEMYAPPLEPHARMAIBRUTINIB 140MG CAPSULES

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