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Moves past the traditional "brick and mortar" model of the barrier. Focuses on the crucial role of Tight Junction proteinsu2014the cellular "glue"u2014and the specific ingredients required to fortify these structures for superior hydration and defense against irritants.
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The 'Glue' That Heals • Presented by Jayashree Salunkhe
Limitations of Ceramide-Centric Approaches • Ceramide Benefits • Missing Elements • Sole reliance on ceramides ignores crucial elements like lipids, proteins, and natural moisturizing factors that are necessary for comprehensive skin barrier restoration and health. • Ceramides enhance skin hydration and help maintain structural integrity, but their effectiveness is limited if other essential components of the skin barrier are overlooked. • Understanding gaps in barrier repair 2
The 'Glue' That Heals • Cholesterol • Free Fatty Acids • NMFs • Free fatty acids contribute to skin’s natural moisturizing factors, supporting hydration and elasticity. Their presence helps restore the skin barrier and protect against environmental aggressors. • Cholesterol plays a critical role in skin barrier function, helping to maintain structure and hydration. It aids in forming lipid bilayers that enhance overall barrier integrity. • Natural moisturizing factors (NMFs) are essential for retaining moisture in the skin. They support barrier function, preventing dryness and promoting a healthy, resilient complexion. • Key components for barrier repair 3
Implications for Skincare Professionals • Understanding skin barrier integrity promotes formulation of balanced lipid mixtures and effective barrier-supporting actives, resulting in improved hydration, reduced sensitivity, and enhanced resilience against environmental stressors for clients.
Enhanced Efficacy of Multi-Lipid Formulations • Multi-lipid formulations have shown significant improvements in skin barrier repair, leading to better hydration, reduced irritation, and enhanced resilience against environmental stressors, ultimately benefiting patients’ overall skin health.
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