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Prenatal Brain Development and Organization

Prenatal Brain Development and Organization. Formation of Neural Tube. Three primordial tissues endoderm mesoderm ectoderm Which tissue does nervous system develop from? ectoderm. Neural crest. Neural crest. Neural Tube Related Birth Defects. Anterior neural pore.

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Prenatal Brain Development and Organization

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  1. Prenatal Brain Development and Organization

  2. Formation of Neural Tube • Three primordial tissues • endoderm • mesoderm • ectoderm • Which tissue does nervous system develop from? • ectoderm

  3. Neural crest

  4. Neural crest

  5. Neural Tube Related Birth Defects Anterior neural pore failure to close = anencephaly Posterior neural pore failure to close = spina bifida

  6. Neural crest becomes peripheral nervous system (PNS) • Neural tube becomes central nervous system (CNS) • Somites become spinal vertebrae. Somites

  7. Prosencephalon or forebrain Mesencephalon or midbrain Rhombencephalon or hindbrain Three-vesicle stage (Week 4)

  8. Five-vesicle stage mesencephalon metencephalon myelencephalon 4 weeks 6 weeks

  9. Differentiation of Forebrain

  10. Human Brain at Birth 14 Years Old 6 Years Old

  11. A lot can go wrong. • Rate of neurogenesis incredibly rapid. • Failure to form appropriate connections may be basis of many neurological and psychiatric disorders.

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