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Robert Koch

Robert Koch. Linking Bacteria to Human Disease. Order of Progress. Prevention Cause Cure. Biography. A doctor who was Born in Prussia in 1843 Interested in Pasteur’s Germ Theory He received a Microscope as a present in 1873 Franco – Prussian Rivalry Franco-Prussian War 1870/1

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Robert Koch

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  1. Robert Koch Linking Bacteria to Human Disease

  2. Order of Progress • Prevention • Cause • Cure

  3. Biography • A doctor who was Born in Prussia in 1843 • Interested in Pasteur’s Germ Theory • He received a Microscope as a present in 1873 • Franco – Prussian Rivalry • Franco-Prussian War 1870/1 • German Government gave Koch money to set up a research institute to rival Pasteur Read Dialogue page 130

  4. Isolating the Germs that caused Anthrax • Explain how 1 Sheep and 20 generations of mice allowed Koch to prove that a particular germ caused Anthrax. Explain why he succeeded?

  5. Germ Cultures • Koch’s isolation technique pioneered the use of culture plates • He extracted the blood from an infected animal • He found that if he injected an animal with the infected blood it would catch the disease much quicker • The more times he did this the stronger the disease would become • Eventually, this germ could be extracted and be encouraged to breed a pure form in a glass culture plate.

  6. The Floodgates open • Using Koch’s methods, other scientists were able to isolate and identify the germs that caused particular diseases • List the causes of diseases discovered in the 1880s and 1890s • Page 131 • However, knowing the cause of these diseases still did not help to treat any sick patients, yet.

  7. Pasteur Strikes back • Prevention • Cause • Cure

  8. Pasteur responds to Robert Koch • Nationalistic Competition • France humiliated by Prussia in 1870/1 war • French Government agrees to finance Pasteur • (Koch already receiving German Government money) • He had a stroke in 1868 • Feeling mortal?

  9. Pasteur Strikes it Lucky • Impressed by Jenner’s work on Smallpox • But Jenner and Pasteur did not understand how vaccination worked • Trial and error • Chicken Cholera, 1879 • Common disease affecting farmers livestock • Pasteur experiments with injecting weaker forms of disease into chickens • Little success • His team goes home for the summer • On return, they accidentally use a strain that had been left uncovered for the whole summer • It works! • Exposure to the air had weakened the germs • “Chance only favours the mind which is prepared”

  10. Pasteur perfects his system • Page 132 • Explain how and for what diseases, Pasteur was able to develop and perfect his system for creating vaccines. • Task page 133 • “Why were the causes of disease finally discovered in the 1860s and 1870s”

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