NutriClean ®

1. NutriClean® Nutritional Support for a healthy Liver and GI Tract Market America Convention 2008! Presented by: Jan DeBenedetto

2. This presentation has not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

3. What can NutriClean® do for me? • Jump Start weight management program! • Revitalize a stale weight management program when you hit that plateau! • Jump start a fitness program! • Restore energy naturally! • Synergize with a stop smoking program! • Generally feel better! • Get things moving!

4. Why do we need NutriClean®?Lifestyle vs. HealthNormal does not mean healthy! • TOO MUCH: • “New to nature” molecules • Processed foods • Synthetic drugs • Environmental toxins • TOO LITTLE • Fresh Veggies • Fresh Fruits • Whole grains • Clean water • Clean air

5. NutriClean® is Internal Maintenance for Health • The body must regularly process, filter and eliminate numerous internal and external substances to stay healthy & alive (35% of blood is filtered by the liver every few minutes) • Internal – hormones, breakdown / waste products of normal metabolism • External – Foods, “foods”, drugs, pollutants, pathogenic toxins, alcohol • This is done primarily by the liver, kidneys and GI systems

6. The Liver • The liver functions to metabolize nutrients, synthesize and store vital biochemicals and to eliminate a variety of unwanted chemicals and toxins from the body. • It also transforms numerous substances into needed biochemicals

7. Liver Detox process • PHASE I • A family of enzymes known as cytochrome p450’s, each processes its own class of chemicals • To detox they add oxygen to the “toxins” to make them more water soluble however, this also creates reactive free radical intermediates. • There are numerous genetic variations in CYP 450’s. (see GeneSNP)

8. Liver Detox - 2 • PHASE 2 • Conjugation enzymes bond the PHASE I products and make them safe and even more soluble for elimination through the bile or via the kidneys. • There are a variety of PHASE II enzymes e.g. glutathione, glucuronidation, methylation, acetylation • Strongly influenced by a natural diet

9. Liver Detox - 3 • Genetics as well as diet, environment, stress and drugs influences your PHASE I enzyme activity • Some drugs speed up the enzymes and this can produce too many free radials • Some drugs slow them down and that weakens natural detoxification and may create a toxic internal state

10. Metabolic waste, drugs, pathogenic toxins, etc. TOXINS Reactive free radical intermediates PHASE I Cytochrome p450s Neutralized Toxins PHASE II Conjugation enzymes Eliminated Toxins

11. Liver’s Detox -- 4 • PHASE II enzymes are primarily activated via dietary phytonutrients • Fresh vegetables and fruits • Cruciferous veggies, many spices/seasonings (e.g. garlic, rosemary, ginger), berries, green tea, • Select Traditional Botanicals • Milk thistle • Schizandra • Select Organics • NAC – N-acetylcysteine – a precursor to the body’s own glutathione

12. GI Functions • The GI Tract is not just a piece of plumbing, it is an active organ involved in • Immunity – An active barrier between you and the outside world • 60% of the lymphatic system is interwoven into the intestines called GALT – Gut Associated Lymphyoid Tissue • Home for healthy microflora • “Unfolded” area equivalent to 2 tennis courts.

13. GI Function • Digestion – • An active chemical process involving numerous enzymes and transport systems • Nutrients are typically actively transported into the body, not just “leaked” in. • The intestines are not easily permeated (that’s a good thing!) • Water/Electrolyte balance • Elimination of wastes • Through daily bowel movements, urination perspiration and the breath

14. GI Health Concerns • ~16% of Americans experience constipation on a regular basis • More women than men by 2:1 • Elderly Americans experience over twice the rate! • Poor diet, poor hydration and lack of exercise contribute to poor bowel health

15. GI Health Concerns • Poor nutrient absorption • Compromised immunity • Skin conditions

16. Historical Remedies for a Healthy GI tract • Since Ancient times cultures worldwide have used diet and natural botanicals to increase peristalsis and maintain bowel health. • Some of the “peristaltic” botanicals included • Cascara sagrada, aloe, rhubarb, buckthorn etc.`

17. Historical Remedies for a Healthy GI tract • Botanicals that support bowel health include: • Scutellaria, oregon grape, walnut husks, golden seal – herbs that to help promote bowel health • Botanicals are typically not used on a regular basis, but they are used for short spans of time periodically. • You should address lifestyle/diet issues if you need them daily

18. Historical Remedies for a Healthy GI tract • Probiotic organisms (MicroFlora) • For centuries cultures worldwide have used a variety of healthful microflora (probiotics) to sustain a healthy body • Many of the longest lived societies consume them regularly • Georgia, Azerbaijan, Ecuador, Himalayas • Antibiotics create a need for probiotic consumption. • Americans overuse antibiotics (drugs & food supply) • Probiotics need to be given in high amounts • Over 1 billion per dose to be effective • Regular consumption • Recent studies show that even “dead” probiotics have immune benefits (via cell wall polysaccharides)

19. Fiber • Our ancestors consumed 5 -10 times as much fiber as we do today • Considerably more fresh veggies, whole grains and fresh fruits • The average American diet contains only a mere 11 grams of fiber per day! • The American Diabetes Association. American Cancer Society and American Heart Association recommend 25 – 35 grams per day.

20. Fiber Benefits • Help maintain healthy levels of cholesterol • Help maintain healthy levels of triglycerides • Help maintain healthy levels of glucose • Help maintain healthy intestinal regularity • Help maintain healthy intestinal microflora • (i.e. food for the “good” bacteria) • Help maintain a biofilm in the GI tract

21. Fibersol 2 (Soluble Fiber) • Unique soluble fiber from corn • Not absorbed into the blood stream • Offers all of the benefits of fiber previously listed • Scientifically studied

22. Fibersol 2 • Increases • Fecal volume • By 1.8X • Fecal frequency • By 1.5X

23. Advanced Fiber PowderInulin • Soluble fiber • Plant derived (from Chicory) • Fructan • Physiological effects are identical to fructooligosaccharides (FOS)

24. Advanced Fiber PowderInulin • Promotes normal levels of high energy SCFA (short chain fatty acids) in the colon via fermentation. • Promotes growth of bifidobacteria and lactobacilli. • Supports normal blood lipids. • Supports normal levels of triglycerides • Promotes normal mineral absorption.

25. NutriClean® Probiotics • 1.5 Billion CFU’s per serving! • Lactobacillus acidophilus • Lactobacillus planturum • Lactobacillus casei • Bifidobacteria bifidum • Lactobacillus sporogenes

26. NutriClean® Glutamine • L - Glutamine is an amino acid • It is fuel for the GI tract • It is fuel for immune cells • It is used in hospitals and for outpatients as a medical food for GI patients • Athletes use it to maintain muscle mass • It has anti-catabolic properties • A natural precursor to Glutathione

27. NutriClean® Use • The Kit is a 7 day program to be used in conjunction with • A diet rich in fresh vegetables and fruits • Low in processed foods • Eliminate any foods that cause upset • Drink a lot of pure water • Exercise

28. NutriClean® Kit - Use • Contents • 7 packets of 2 Hepatocleanse capsules and 4 Release quick acting tablets • 1 jar of 7 servings of tasty Advanced Fiber Powder • Directions for Use • 1 spoonful of Advanced Fiber Powder before bedtime in water • Contents of 1 packet before bedtime

29. NutriClean® Kit - Use • If during the course of use you experience too many trips to the bathroom or excessively loose stools • Reduce the number of tablets you take • Suggested Use • 2 -12 Cycles over the course of 1 year depending on your needs and lifestyle

30. NutriClean® Precautions • Not for use by pregnant or lactating women • If you are under the care of a physician or taking prescription medication consult your physician • Discontinue use if any discomfort is experienced

31. NutriClean® – Product Extensions Advanced Fiber Powder • Advanced Fiber Powder(One Month Supply) • The same product as in the NutriClean® Kit • Safe and effective for daily use for everyone in the family who needs more healthful fiber in their diet (who doesn’t?!) • Much healthier than simple laxative fibers

32. NutriClean® – Product Extensions Hepatocleanse • HepatoCleanseis intended to support healthy liver function • Can be used daily • Great for those who • Smoke • Consume alcohol • Exposed to toxins • Eat diet low in fresh vegetables, fruits and whole grains • Eat a lot of processed foods.

33. Nutriclean® Aloe • Long history of safe use • Depicted as “Plant of Immortality” in 6000 year old Egyptian stone carvings • Used in Ancient Egypt for health promoting effects • Alexander the Great conquered Socotra to get control of Aloe

34. NutriClean® – Product Extensions Release • Everyone is different... • For those requiring more “help” in their cleansing regimen Market America offers Release as a stand alone product

35. NutriClean® Applications -- Summary • Jump Start weight management program! • Revitalize a weight management program when you hit a plateau! • Jump start a fitness program! • Restore energy naturally! • Synergize with a stop smoking program! • Generally feel better! • Get things moving!