Canesten Vaginal Cream (Generic Clotrimazole Vaginal Cream)

1. Canesten Vaginal Cream (Generic Clotrimazole Vaginal Cream) © The Swiss Pharmacy

2. Canesten Vaginal Cream (Generic Clotrimazole Vaginal Cream) Canesten Vaginal Cream (Generic Clotrimazole Vaginal Cream) is used to treat a fungal infection in the vagina and vulval area(thrush). It should be used as an adjunct to treatment of candidal vaginitis. It can also be used for treatment of the sexual partner's penis to prevent re-infection. © The Swiss Pharmacy

3. Canesten Vaginal Cream (Generic Clotrimazole Vaginal Cream) Canesten Vaginal Cream is manufactured by Bayer Zydus Pharma, India in the strength of 2% and is available in a 30 grams tube. © The Swiss Pharmacy

4. Canesten Vaginal Cream (Generic Clotrimazole Vaginal Cream) What is a Vaginal Yeast Infection? A yeast infection is a common type of vaginal infection. Your doctor may call it candidiasis. This condition is caused by an organism called Candida, which is a type of yeast. Healthy women usually have this yeast on the skin, in the mouth, in the digestive tract, and in the vagina. At times, the yeast can grow very quickly. In fact, the infection is sometimes called yeast (Candida) “overgrowth.” Some women may have a yeast infection on the skin outside the vagina (vulva) associated with the vaginal infection. A yeast infection can occur at any age. It is most common during the childbearing years. Women who are pregnant or diabetic, taking antibiotics, birth control pills or steroids, or who have a weakened immune system are more likely to get repeated yeast infections. © The Swiss Pharmacy

5. Canesten Vaginal Cream (Generic Clotrimazole Vaginal Cream) Chemical Structure © The Swiss Pharmacy

6. Canesten Vaginal Cream (Generic Clotrimazole Vaginal Cream) The active ingredient contained in Canesten Vaginal Cream is Clotrimazole. Each gram of Canesten Vaginal Cream contains 20 mg of Clotrimazole. © The Swiss Pharmacy

7. Canesten Vaginal Cream (Generic Clotrimazole Vaginal Cream) Uses of Canesten 2% Vaginal Cream: Canesten Vaginal Cream (Generic Clotrimazole Vaginal Cream) is used to treat vaginal yeast infections. Clotrimazole reduces vaginal burning, itching, and discharge that may occur with this condition. This medication is an azole antifungal. It works by stopping the growth of yeast (fungus) that causes the infection. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9527_Canesten-Vaginal-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9527_Canesten-Vaginal-Cream.html © The Swiss Pharmacy

8. Canesten Vaginal Cream (Generic Clotrimazole Vaginal Cream) Recommended Adult Dosage The dose of Canesten Vaginal Cream Canesten Vaginal Cream (Generic Clotrimazole Vaginal Cream) is given below: Canesten Vaginal Cream should be applied thinly two or three times daily and rubbed in gently. Treatment should be continued until symptoms of the infection disappear. However, if after concomitant treatment of the vaginitis, the symptoms do not improve within seven days, the patient should consult a doctor. If the cream is being used for treatment of the sexual partner's penis it should be applied two or three times daily for up to two weeks. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9527_Canesten-Vaginal-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9527_Canesten-Vaginal-Cream.html © The Swiss Pharmacy

9. Canesten Vaginal Cream (Generic Clotrimazole Vaginal Cream) Contraindications ➔Canesten Vaginal Cream is contraindicated in patients with a known hypersensitivity to Clotrimazole or any component of the cream. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9527_Canesten-Vaginal-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9527_Canesten-Vaginal-Cream.html © The Swiss Pharmacy

10. Canesten Vaginal Cream (Generic Clotrimazole Vaginal Cream) Storage Instructions Canesten Vaginal Cream (Generic Clotrimazole Vaginal Cream) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9527_Canesten-Vaginal-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9527_Canesten-Vaginal-Cream.html © The Swiss Pharmacy

11. Canesten Vaginal Cream (Generic Clotrimazole Vaginal Cream) Warnings Medical advice should be sought if this is the first time the patient has experienced symptoms of candidal vaginitis. Before using Canesten Vaginal Cream medical advice must be sought if any of the following are applicable: - more than two infections of candidal vaginitis in the last six months - previous history of a sexually transmitted disease or exposure to partner with sexually transmitted disease - pregnancy or suspected pregnancy - aged under 16 or over 60 years - known hypersensitivity to imidazoles or other vaginal antifungal products URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9527_Canesten-Vaginal-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9527_Canesten-Vaginal-Cream.html © The Swiss Pharmacy

12. Canesten Vaginal Cream (Generic Clotrimazole Vaginal Cream) Warnings Canesten Vaginal Cream should not be used if the patient has any of the following symptoms whereupon medical advice should be sought: irregular vaginal bleeding, abnormal vaginal bleeding or a blood- stained discharge, vulval or vaginal ulcers, blisters or sores, lower abdominal pain or dysuria, any adverse events such as redness, irritation or swelling associated with the treatment, fever or chills, nausea or vomiting, diarrhoea or foul smelling vaginal discharge URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9527_Canesten-Vaginal-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9527_Canesten-Vaginal-Cream.html © The Swiss Pharmacy

13. Canesten Vaginal Cream (Generic Clotrimazole Vaginal Cream) Warnings In case symptoms persist for more than 7 days the patient should be evaluated by a medical practitioner. Recurrent infections may indicate an underlying medical cause. Patient should seek medical advice if symptoms return within 2 months. Treatment during the menstrual period should not be performed. The treatment should be completed before the onset of menstruation. Tampons, intravaginal douches, spermicides or other vaginal preparations should not be used while using Canesten Vaginal Cream . Avoidance of vaginal intercourse is recommended in case of vaginal infection and while using Canesten Vaginal Cream. Canesten Vaginal Cream is intended for use by adults and children 12 years of age and older only. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9527_Canesten-Vaginal-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9527_Canesten-Vaginal-Cream.html © The Swiss Pharmacy

14. Canesten Vaginal Cream (Generic Clotrimazole Vaginal Cream) Possible Side Effects Large scale clinical studies have shown Canesten Vaginal Cream (Generic Clotrimazole Vaginal Cream) to be well tolerated after topical application. The side effects of Canesten Vaginal Cream are given below: Immune system disorder: allergic reaction (syncope, hypotension, dyspnea, urticaria) Skin and subcutaneous tissue disorders: blisters, discomfort / pain, oedema, erythema, irritation, peeling / exfoliation, pruritus, rash, stinging / burning URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9527_Canesten-Vaginal-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9527_Canesten-Vaginal-Cream.html © The Swiss Pharmacy

15. Canesten Vaginal Cream (Generic Clotrimazole Vaginal Cream) Possible Side Effects Gastrointestinal disorders: Abdominal pain If you experience an allergic reaction or the redness, burning, pain, itching or swelling get worse, stop using this product and tell your doctor straight away. Signs of an allergic reaction may include: Rash, Swallowing or breathing problems, Swelling of your lips, face, throat or tongue, Weakness, feeling dizzy or faint, Nausea. After you apply Canesten Vaginal Cream you might experience: Itching, rash, swelling, redness, discomfort, burning,irritation, vaginal peeling or bleeding, Pain in the abdomen or pelvic area. In case you experience any of the above effects, tell your doctor immediately. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9527_Canesten-Vaginal-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9527_Canesten-Vaginal-Cream.html © The Swiss Pharmacy

16. Canesten Vaginal Cream (Generic Clotrimazole Vaginal Cream) Canesten Vaginal Cream Overdosage Acute overdosage with topical application of Clotrimazole Vaginal Cream is unlikely and would not be expected to lead to a life- threatening situation. There is no specific antidote. In case of accidental ingestion, gastro-intestinal disturbances and central nervous system depression may occur. Treatment is symptomatic and supportive. However, in the event of accidental oral ingestion, routine measures such as gastric lavage should be performed only if clinical symptoms of overdose become apparent (e.g. dizziness, nausea or vomiting). Gastric lavage should be carried out only if the airway can be protected adequately. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9527_Canesten-Vaginal-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9527_Canesten-Vaginal-Cream.html © The Swiss Pharmacy

17. Canesten Vaginal Cream (Generic Clotrimazole Vaginal Cream) Clotrimazole Vaginal Cream During Pregnancy Clotrimazole Vaginal Cream (Canesten Vaginal Cream) has been classified by the US FDA as Pregnancy Category B. Clotrimazole is very poorly absorbed following dermal application or intravaginal administration to humans. In clinical trials, use of vaginally applied Clotrimazole in pregnant women in their second and third trimesters has not been associated with ill effects. There are, however, no adequate and well-controlled studies in pregnant women during the first trimester of pregnancy. As a precautionary measure, it is preferable to avoid the use of Canesten Vaginal Cream during the first trimester of pregnancy. Studies in pregnant rats with intravaginal doses up to 100 mg/kg have revealed no evidence of harm to the fetus due to Clotrimazole. High oral doses of Clotrimazole in rats and mice ranging from 50 to 120 mg/kg resulted in embroyotoxicity, impairment of mating, decreased litter size and number of viable young and decreased pup survival to weaning. © The Swiss Pharmacy

18. Canesten Vaginal Cream (Generic Clotrimazole Vaginal Cream) Canesten Vaginal Cream Canesten Vaginal Cream (Generic Clotrimazole Vaginal Cream) is manufactured by Bayer Zydus Pharma, India. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9527_Canesten-Vaginal-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9527_Canesten-Vaginal-Cream.html © The Swiss Pharmacy