Virovir Tablets (Generic Famciclovir Tablets)

1. Virovir Tablets (Generic Famciclovir Tablets) © The Swiss Pharmacy

2. Virovir Tablets (Generic Famciclovir Tablets) Virovir (Generic Famciclovir Tablets) is used for the treatment of recurrent herpes labialis (cold sores) and for the treatment of recurrent episodes of genital herpes as well as for chronic suppressive therapy of recurrent episodes of genital herpes in immunocompetent adult patients. In HIV-infected adult patients, this medicine is used to treat recurrent episodes of orolabial or genital herpes in HIV- infected adults. © The Swiss Pharmacy

3. Virovir Tablets (Generic Famciclovir Tablets) Virovir Tablets are manufactured by FDC Limited, India in the strengths of 250 mg and 500 mg. © The Swiss Pharmacy

4. Virovir Tablets (Generic Famciclovir Tablets) Chemical Structure © The Swiss Pharmacy

5. Virovir Tablets (Generic Famciclovir Tablets) The active ingredient contained in Virovir tablets is Famciclovir. Each film coated Virovir tablet contains 250 mg or 500 mg of Famciclovir. © The Swiss Pharmacy

6. Virovir Tablets (Generic Famciclovir Tablets) Uses of Virovir 250 mg and 500 mg Tablets: Virovir (Generic Famciclovir Tablets) is used to treat infections caused by certain types of viruses. It treats shingles caused by herpes zoster, a herpes virus infection of the skin. It also treats outbreaks of herpes simplex that cause cold sores around the mouth, sores around the anus, and genital herpes. In people with frequent outbreaks of genital herpes, Famciclovir is used to help reduce the number of future episodes. This medicine is also used to treat recurrent herpes virus infections of the mucous membranes (lips and mouth) and genitals in HIV- infected patients. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9687_Virovir-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9687_Virovir-Tablets.html © The Swiss Pharmacy

7. Virovir Tablets (Generic Famciclovir Tablets) Uses of Virovir 250 mg and 500 mg Tablets: Famciclovir is an antiviral drug. However, it is not a cure for these infections. The viruses that cause these infections continue to live in the body even between outbreaks. Famciclovir decreases the severity and length of these outbreaks. It helps the sores heal faster, keeps new sores from forming, and decreases pain/itching. This medication may also help reduce how long pain remains after the sores heal. In addition, in people with a weakened immune system, Famciclovir can decrease the risk of the virus spreading to other parts of the body and causing serious infections. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9687_Virovir-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9687_Virovir-Tablets.html © The Swiss Pharmacy

8. Virovir Tablets (Generic Famciclovir Tablets) Recommended Adult Dosage The recommended dose of Virovir Tablets Tablets) to treat immunocompetent adult patients for various indications is given below: Herpes Labialis (Cold Sores): The recommended dosage of Famciclovir tablets for the treatment of recurrent herpes labialis is 1500 mg as a single dose. Therapy should be started at the first sign or symptom of herpes labialis (e.g., tingling, itching, burning, pain, or lesion). Genital Herpes Recurrent Episodes: The recommended dosage of Famciclovir tablets for the treatment of recurrent episodes of genital herpes is 1000 mg twice daily for 1 day. Therapy should be initiated at the first sign or symptom of a recurrent episode (e.g., tingling, itching, burning, pain, or lesion). Virovir Tablets (Generic Famciclovir URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9687_Virovir-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9687_Virovir-Tablets.html © The Swiss Pharmacy

9. Virovir Tablets (Generic Famciclovir Tablets) Recommended Adult Dosage Genital Herpes Suppressive Therapy: The recommended dosage of Virovir tablets for chronic suppressive therapy of recurrent episodes of genital herpes is 250 mg twice daily. Herpes Zoster (Shingles): The recommended dosage of Famciclovir tablets (Virovir) for the treatment of herpes zoster is 500 mg every 8 hours for 7 days. Therapy should be started as soon as herpes zoster is diagnosed. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9687_Virovir-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9687_Virovir-Tablets.html © The Swiss Pharmacy

10. Virovir Tablets (Generic Famciclovir Tablets) Recommended Dosage in HIV-Infected Adult Patients Recurrent Orolabial or Genital Herpes: The recommended dosage of Famciclovir tablets for the treatment of recurrent orolabial or genital herpes in HIV-infected patients is 500 mg twice daily for 7 days. Therapy should be initiated at the first sign or symptom of a recurrent episode (e.g., tingling, itching, burning, pain, or lesion). URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9687_Virovir-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9687_Virovir-Tablets.html © The Swiss Pharmacy

11. Virovir Tablets (Generic Famciclovir Tablets) Contraindications ➔Virovir is contraindicated in patients with a known hypersensitivity to Famciclovir, Penciclovir, or any component of the tablet. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9687_Virovir-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9687_Virovir-Tablets.html © The Swiss Pharmacy

12. Virovir Tablets (Generic Famciclovir Tablets) Storage Instructions Virovir Tablets (Generic Famciclovir Tablets) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9687_Virovir-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9687_Virovir-Tablets.html © The Swiss Pharmacy

13. Virovir Tablets (Generic Famciclovir Tablets) Warnings Acute renal failure: Cases of acute renal failure have been reported in patients with underlying renal disease who have received inappropriately high doses of Famciclovir (Virovir tablets) for their level of renal function. Dosage reduction is recommended when administering Famciclovir to patients with renal impairment. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9687_Virovir-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9687_Virovir-Tablets.html © The Swiss Pharmacy

14. Virovir Tablets (Generic Famciclovir Tablets) Warnings In patients with impaired renal function dose adjustment is necessary. Famciclovir has not been studied in patients with severe hepatic impairment. Conversion of Famciclovir to its active metabolite Penciclovir may be impaired in these patients resulting in lower Penciclovir plasma concentrations, and thus a decrease of efficacy of Famciclovir may occur. Clinical response should be closely monitored, particularly in immunocompromised patients. Consideration should be given to intravenous antiviral therapy when response to oral therapy is considered insufficient. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9687_Virovir-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9687_Virovir-Tablets.html © The Swiss Pharmacy

15. Virovir Tablets (Generic Famciclovir Tablets) Warnings Patients should be advised to avoid intercourse when symptoms are present even if treatment with an antiviral has been initiated. During suppressive treatment with antiviral agents, the frequency of viral shedding is significantly reduced. However, transmission is still possible. Therefore, in addition to therapy with Famciclovir (Virovir tablets), it is recommended that patients use safer sex practices. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9687_Virovir-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9687_Virovir-Tablets.html © The Swiss Pharmacy

16. Virovir Tablets (Generic Famciclovir Tablets) Possible Side Effects Most common Famciclovir (Virovir tablets) side effects with an incidence rate of greater than 10% of adult patients are headache and nausea. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9687_Virovir-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9687_Virovir-Tablets.html © The Swiss Pharmacy

17. Virovir Tablets (Generic Famciclovir Tablets) Possible Side Effects The following side effects have been reported during postapproval use of Famciclovir: Blood and lymphatic system disorders: Thrombocytopenia Hepatobiliary disorders: Abnormal liver function tests, cholestatic jaundice Immune system disorders: Anaphylactic shock, anaphylactic reaction Nervous system disorders: Dizziness, somnolence, seizure Psychiatric disorders: Confusion (including delirium, disorientation, and confusional state occurring predominantly in the elderly), hallucinations Skin and subcutaneous tissue disorders: Urticaria, erythema multiforme, Stevens- Johnson syndrome, toxic epidermal necrolysis, angioedema (e.g., face, eyelid, periorbital, and pharyngeal edema), hypersensitivity vasculitis Cardiac disorders: Palpitations URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9687_Virovir-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9687_Virovir-Tablets.html © The Swiss Pharmacy

18. Virovir Tablets (Generic Famciclovir Tablets) Virovir Tablets Overdosage Overdose experience with Famciclovir (Virovir tablets) is limited. In the event of an overdose supportive and symptomatic therapy should be given as appropriate. Acute renal failure has been reported rarely in patients with underlying renal disease where the Famciclovir dose has not been appropriately reduced for the level of renal function. Penciclovir is removed by hemodialysis. Plasma concentrations are reduced by approximately 75% following 4h haemodialysis. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9687_Virovir-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9687_Virovir-Tablets.html © The Swiss Pharmacy

19. Virovir Tablets (Generic Famciclovir Tablets) Virovir Tablets During Pregnancy Famciclovir (Virovir tablets) has been classified by the US FDA as Pregnancy Category B. After oral administration, Famciclovir (prodrug) is converted to Penciclovir (active drug). There are no adequate and well-controlled studies of Famciclovir or Penciclovir use in pregnant women. No adverse effects on embryofetal development were observed in animal reproduction studies using Famciclovir and Penciclovir at doses higher than the maximum recommended human dose (MRHD) and human exposure. Since animal reproduction studies are not always predictive of human response, Famciclovir (Virovir tablets) should be used during pregnancy only if needed. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9687_Virovir-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9687_Virovir-Tablets.html © The Swiss Pharmacy

20. Virovir Tablets (Generic Famciclovir Tablets) Virovir Tablets Virovir Tablets (Generic Famciclovir Tablets) are manufactured by FDC Limited, India. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9687_Virovir-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9687_Virovir-Tablets.html © The Swiss Pharmacy