Osteoporosis Osteoporosis - - Cannabis Compound Cannabis Compound Hardens Bone Hardens Bone Another research paper has just been released that demonstrates how plant based chemicals can help to include the fragile bone disease, osteoporosis. Researchers at the Institute of Medical Sciences, University of Aberdeen, UK have found how a non-psychoactive compound in cannabis, cannabidiol can help to preserve bone strength. The endocannabinoid system is a group of mobile receptors which are activated by means of a group of endogenous lipids as well as compounds derived from the cannabis plant. The cannabinoid receptors have been involved in a number of physiological processes including appetite control, pain, mood and memory. Recent research has proven that the endocannabinoid system also has a powerful influence on bone metabolism, as the receptors are well represented on osteoclasts - cells whose main function is to resorb (lean out) bone.
Bone is an active, living tissue which is being continuously formed, remodeled and shaped in reaction to both physiological and physical demands of the body. Bone matrix is made up chiefly of the macronutrients calcium, magnesium and phosphate and is the material that makes up both the dense areas of the bone and the bone marrow frame. Many individuals still feel that if a person eats foods rich in these minerals then they will avoid developing osteoporosis. Epidemiological and other evidence suggests that this isn't necessarily the case. If it comes to bone health and disease the integrated processes that control the formation and resorption bone are just as important as the availability of calcium, magnesium and phosphate. The formation and resorbtion of bone matrix is controlled by two Major cell types: 1) Osteoblasts are bone cells that are responsible for the creation of bone matrix 2) Osteoclasts are modified white blood cells responsible for the resorption of bone tissue. These two cell types are controlled by a intricate set of signaling hormones, proteins and cell receptors which respond to the ever-changing demands on bone tissue and other physiological processes. If there are too many osteoclasts, or when these cells become overactive, they will resorb more matrix compared to the osteoblasts may produce. A predominance of osteoclast activity results in the bone becoming less dense - the principal characteristic of the clinical condition known as osteoporosis. The Aberdeen researchers have discovered that cannabidiol binds to a specific cannabinoid receptor on the bone-resorbing osteoblast cells. By so doing this inhibits these cells out of resorbing the bone matrix - thus helping to prevent further weakening of the bones.
This is not the first time that plant chemicals have been proven to affect bone metabolism in favour of more powerful bones. In January 2009 researchers at Oklahoma State University in the USA discovered that, even in the presence of oxidative stress and systemic inflammation, polyphenols derived from plums inhibit the activity of their bone-softening osteoclasts but boost the generation and activity of bone-building osteoblasts. For people who hope that smoking pot will help to reinforce their bones, they do so in vain. Although wild cannabis contains around 40 percent cannabidiol, cultivated varieties contain very little of the compound. The important point arising out of this study, in my view, is that it shows how vital plant chemicals are in the prevention of chronic degenerative diseases like osteoporosis. There are certain to be several different phytonutrients in other food crops that have a positive influence on bone metabolism - they just have not been "discovered" yet. While we wait for that research to be carried out, it's very important to consume (not smoke) that a wide assortment of vegetables, spices and fruit to ensure a sufficient intake of a host of valuable phytonutrients. CBD Isolate CBD Isolate provide the highest-quality, pharmaceutical grade CBD hemp oil, hemp seeds, hemp clones and hemp flower; all grown and processed in the United States.