1 / 14

NORTH WESTERN CANCER REGISTRY

NORTH WESTERN CANCER REGISTRY. Introduction. BLADDER CANCER: Later stage and worse survival in women from deprived areas. British Journal of Cancer (2004) 90, 2142-2144. North Western Cancer Registry T.Moran A-M Sowerbutts Stuart Collins R Hartley D.Chandler.

abedi
Télécharger la présentation

NORTH WESTERN CANCER REGISTRY

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. NORTH WESTERN CANCER REGISTRY Introduction BLADDER CANCER: Later stage and worsesurvival in women from deprived areas British Journal of Cancer (2004) 90, 2142-2144 North WesternCancer Registry T.Moran A-M Sowerbutts Stuart Collins R Hartley D.Chandler Christie Hospital NHS Trust N.Clarke R.Cowan

  2. NORTH WESTERN CANCER REGISTRY Background • Bladder is the only common cancer for which women have a worse survival than men • Largest gap at one year • Some evidence that women are more likely to present with later stage disease Aim of study: To determine why women have a worse prognosis than men: a) Do women present later? b) Is social deprivation a factor?

  3. NORTH WESTERN CANCER REGISTRY Criteria for study subjects • Resident of Greater Manchester, Lancashire and South Cumbria • Muscle-invasive tumour diagnosed in 1998 (MID) • No history of bladder cancer

  4. NORTH WESTERN CANCER REGISTRY Methods I • 1190 Patients with bladder tumours identified from North Western Cancer Registry database • Pathology reports reviewed to identify those with histologically verified muscle-invasive disease • Case notes requested on: (i) Those with histologically verified MID (ii) Those who underwent cystectomy or radiotherapy (iii) Those who died within 3 years of diagnosis • 90% reviewed

  5. NORTH WESTERN CANCER REGISTRY Methods II Deaths classified into those due to bladder cancer and to other causes Stage classified into advanced (T4b and/or M1) and non-advanced Deprivation measured using the Townsend Score

  6. NORTH WESTERN CANCER REGISTRY Statistics • Frequency distribution • 2 and t-tests • Survival • Kaplan-Meier • Log-Rank test

  7. NORTH WESTERN CANCER REGISTRY Characteristics of Study Population (347) Median Age Male 227 (65.5%) 72.5 Female 120 (34.5%) 75.5

  8. NORTH WESTERN CANCER REGISTRY Difference in cause-specificsurvival by sex Time Difference(Months) 3 10.9% 6 19.9%* 12 15.8% 36 9.9% 49 women and 48 men died from bladder cancer in the first six months * Log-Rank 2 = 14.7; 1 df; p<0.01

  9. NORTH WESTERN CANCER REGISTRY Advanced stage at diagnosis Male 33(14.5%) Female 35 (29.2%) (2 = 10.7; 1 df; p<0.01)

  10. NORTH WESTERN CANCER REGISTRY Number (%) with advanced disease by deprivation quintiles Quintile Male Female 1 8 (17.8%) 3 (15.8%) 2 5 (11.9%) 0 ( 0.0%) 3 4 (12.1%) 9 (31.0%) 4 7 (11.9%) 9 (36.0%) 5 9 (18.8%) 14 (43.8%) Total 33 (14.5%) 35 (29.2%)

  11. NORTH WESTERN CANCER REGISTRY Six-month survival ratesby deprivation quintiles Survival Rate (%) Quintile More deprived

  12. NORTH WESTERN CANCER REGISTRY Survival and stage by two deprivationcategories for females Number (%) with Six-Month Survival Advanced Disease Quintiles 3 (8.8%) 73.5% 1+2 Quintiles 32 (37.5%) 52.3% 3+4+5 More deprived Worse (2 = 4.8; 1 df; p<0.05) (2 = 9.5; 1 df; p<0.01)

  13. NORTH WESTERN CANCER REGISTRY Conclusion Women from more deprived backgrounds present with later stage disease and have a worse prognosis than either men or women from less deprived neighbourhoods.

  14. NORTH WESTERN CANCER REGISTRY BLADDER CANCER: Later stage and worsesurvival in women from deprived areas British Journal of Cancer (2004) 90, 2142-2144 North WesternCancer Registry T.Moran A-M Sowerbutts Stuart Collins R Hartley D.Chandler Christie Hospital NHS Trust N.Clarke R.Cowan

More Related