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Gene Expression Profiles for Diagnosing and Prognosing Acute Lymphoblastic Leukemia (ALL)

This study investigates the gene expression profiles in various subtypes of Acute Lymphoblastic Leukemia (ALL), focusing on hyperdiploid cases with >50 chromosomes and specific genetic translocations such as E2A-PBX1 and TEL-AML1. Utilizing a sample of 327 cases, we identify key genes associated with diagnosis, relapse, and prognosis. Our findings highlight the heterogeneity of ALL and propose a framework for understanding gene-based distinctions among subtypes, which may aid in the development of targeted therapies and better outcomes for patients.

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Gene Expression Profiles for Diagnosing and Prognosing Acute Lymphoblastic Leukemia (ALL)

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  1. Diagnostic ALL BM Samples (n = 327) Genes for class distinction (n=271) E2A-PBX1 MLL T-ALL Hyperdiploid > 50 BCR-ABL Novel TEL-AML1 -3 -2 -1 0 1 2 3

  2. ALL is a highly heterogeneous disease

  3. T-ALL Hyperdiploid>50 E2A-PBX1 TEL-AML1 A Principle components of expression profiles of genes for ALL subtype diagnosis

  4. Dx ALL  2nd AML Dx ALL  relapse Dx ALL  CCR Relapsed ALL Principle components of expression profiles of genes for ALL prognosis

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