1 / 12

The Scientific Literature

The Scientific Literature. Honors Cup 2005 1/13/05. General 216 Announcements. Office Hours: 3:30-5:00 2404 Thursdays GSI “office hours” Post experiment 1 details ~5pm on Friday at: http://www.umich.edu/~chemh215/CHEM216/216Hhome.htm NMR. The Honors Cup. Proposal

adara-pugh
Télécharger la présentation

The Scientific Literature

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. The Scientific Literature Honors Cup 2005 1/13/05

  2. General 216 Announcements • Office Hours: 3:30-5:00 2404 Thursdays • GSI “office hours” • Post experiment 1 details ~5pm on Friday at: http://www.umich.edu/~chemh215/CHEM216/216Hhome.htm • NMR

  3. The Honors Cup • Proposal • Check (Fri 1/28 10 am e-mail to Dr. Gottfried) • Final Version (Monday 2/7 10am e-mail to Dr. Gottfried • Peer Review • Week of 2/7; review all proposals in section using rubric provided by 10 am Friday 2/11 • Synthesis • Last six weeks of lab

  4. The Proposal • Target: what is it and why is it (or the series of transformations) important • Overall Scheme • For each step • A ChemDraw picture of the transformation • An experimental • Any green or safety issues • Budget • References

  5. Goals for your Proposal • Interesting process or molecule that you would like to carry out • 3 synthetic transformations • 216H doable experimentals • Time • Scale • Equipment and technique • 0.5 g final product • Doable characterization

  6. Interesting Molecule or Process • Forward • What synthetic transformations are you interested in? • What processes are most interesting? • Do you want to use a green reaction? • Retro Synthesis • What molecule are you interested in making? • Make a functional group like that of a larger molecule.

  7. What is NOT a Synthetic Transformation? • A synthetic transformation changes one functional group to another. • Remember you need to isolate and characterize the product of each step. • Reaction work-ups and extractions are not synthetic transformations.

  8. Extraction 55.555g of ground nutmeg is to be heated under reflux for 30 minutes with 138.888mL of diethyl ether (6). The mixture should be cooled to room temperature and the solid decanted. Wash with 55.555mL of diethyl ether, and distillthe liquid to recover the solvent (7). 11.666g of solid yellow residue will appear. Recrystallization from ethanol is possible to recover 2.833g of trimyristin (a white solid, 5% yield based on starting nutmeg) with MP 56-58 oC and Rf .5 on TLC (Thin Layer Chromatography) with Hexane solvent system (1). .

  9. Overall Reaction Scheme : A 3-Step Synthesis

  10. Where do I get ideas? • Medicine cabinet • Internet • Flip through journals • Fragrances, flavors • Labels and ingredients

  11. Forbidden Fruits • Aspirin • Dulcin • Mysteric acid

  12. Once you have an idea…. • www.lib.umich.edu • Electronic Journals and Newspapers • Networked Electronic Resources • SciFinder (SLC PCs and Macs) • Author • Transformation • Molecule (synthesis, etc.) • Beilstein (SLC PCs) • Characterization • Synthesis

More Related