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Enhanced Antimicrobial Polyurethane via Fluorous Surface Modifiers for Biomedical Applications

This research explores antimicrobial properties of a modified polyurethane using a fluorinated side chain, incorporating C-12 alkylammonium for biocidal efficacy. At only 2wt% modifier concentration, the polymer achieves full elimination of E. coli, S. aureus, and P. aeruginosa in just 30 minutes post aerosol exposure. Potential applications include catheters and gloves, significantly enhancing infection control. Collaborative efforts include international training for graduate students and interdisciplinary research among experts at Virginia Commonwealth University and beyond.

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Enhanced Antimicrobial Polyurethane via Fluorous Surface Modifiers for Biomedical Applications

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  1. Surface Concentration of Antimicrobial Function Kenneth J. Wynne, Virginia Commonwealth University, DMR 0207560 Polymer Surface Modifier A A B B P[AB] = Bulk polyurethane • Fluorous side chain A surface-concentrates biocidal C-12 alkylammonium B (n = 0.11) • Only 2wt% P[AB] polyurethane modifier effects complete kill in 30 min of aerosol spray of E. coli, S. aureus, and P. aeruginosa • Potential applications: catheters, gloves Complete kill on 2wt% modified polyurethane Control 464 colonies P. aeruginosa • Collaborative, interdisciplinary research: Grad student, Pinar Kurt (CLSE); Drs. D. Ohman, Lynn Wood, VCU School of Medicine, Department of Microbiology and Immunology • Kurt, P.; Wood, L.; Ohman, D. E.; Wynne, K. J., Langmuir; (Letter); 23(9); 4719-4723, 2007.

  2. Functional Polymer Surfaces Kenneth J. Wynne, Virginia Commonwealth University, DMR 0207560 • Outreach: • Collaborative international training for graduate students from Kyoto Univ. (Prof. Chujo) and Univ. of Pisa (Prof. Chiellini and Prof. Galli). • Collaborative international training in surface science for undergrads from Koç Univ. (Prof. Yilgor) • Panel member, May 07, NSF STC “Center on Materials and Devices for Information Technology Research”, University of Washington, Seattle • Co-Organizer, K-12 Workshop / Symposium “Polymer Science of Everyday Things”, Boston ACS, August 07. • Education: • Two Ph.D.’s: Dr. Janelle Uilk (Phillip Morris) and Dr. Umit Makal (Novion) • One post-doctoral: Professor Tomoko Fujiwara (U. Memphis) • REU undergrads 06: Ms. R. Wickham (Grad School U. Md, Fall 07). • Three Ph.D. graduate students are being trained: Ms. Pinar Kurt (4th yr), Ms. Allison Mullins (3rd yr and Mr. Kennard Brunson (2nd yr). • Grad course development: Polymers in Medicine

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