FaceBase Developing 3D Craniofacial Morphometry Data and Tools to Transform Dysmorphology Richard A. Spritz, MD Ophir Klein, MD, PhD Benedikt Hallgrimsson, PhD http://www.easy-dna.com/printed-dna-art.html
Overview • What is FaceBase? • Previous Work • Purpose • Our Goals • How to Participate – 3D Photos • What will happen to the data we collect?
What is FaceBase? A group of research teams around the country studying facial development and facial characteristics. www.facebase.org
Previous Work FaceBase1 • We studied genetic data and facial shape in Tanzanian children • We showed that 3D photos could distinguish altered facial development from normal
Diagnostic Methods can be Improved • Not sufficiently objective - Syndrome descriptions sometimes unclear • Measurement Error - Manual measures are not very accurate or precise • Limited Technology • Some 2D and 3D photos • Imprecise landmarking
Our Goals • Library of 3D Facial Scans • Diagnostic Aid for Physicians and Scientists • “Quantitative Science”
How Does it Work? • Dense Surface Modeling • Geometric Morphometrics • Automated facial landmarking • Combine these analytical tools • Apply to Clinical Practice! Spritz et al Storage, William. Augustus Once And For All
What will I need to do? • Sign up for an appointment • Sign consent forms: - I will go over the consent form with you - HIPAA, Patient Bill of Rights • Medical Information Form • Includes consent for “data-sharing”; De-identified photos and data to be deposited in NIH FaceBase “Hub” database. May be shared to qualified researchers approved by NIH “Data Access Committee”.
3D Photos: How to Participate • 4 Face views will be collected • Tie hair back • Sit still just like for a normal picture • About 10-20 minutes total • Each participant will be given an anonymous study number to preserve confidentiality
What will happen tomy Photo and Data? • We will take your 3D photo 2. We will analyze the 3D image 3. We will place anatomic landmarks on the 3D image 4. We will analyze the 3D images of patients with a specific known syndrome to define features characteristic of each syndrome 5. We will develop methods to distinguish among different syndromes
Key Points • FaseBase2 is a research study, and is part of a larger international project • We aim to improve how we diagnose genetic syndromes that include atypical facial development • We need participants to take 3D Photos • Let me know if you are interested and sign up for an appointment!
Thank you! Are there any questions?