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Analysis of BRAF V600E Mutation and MMR Status in Randomized MLH1 and MSH2 Immunohistochemistry

This study examines the availability of MMR and BRAF status in a randomized sample using immunohistochemistry for MLH1 and MSH2. It reports on the frequency of assay failures due to insufficient material and highlights the distribution of V600E BRAF mutations in the context of colorectal cancer. Understanding the relationship between BRAF mutations and MMR status can aid in predicting treatment responses and making informed clinical decisions.

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Analysis of BRAF V600E Mutation and MMR Status in Randomized MLH1 and MSH2 Immunohistochemistry

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  1. CONSORT diagram 2170 randomized 2100 block available MLH1 and MSH2 immunohistochemistry V600E BRAF mutation assay 336 assay failure or not enough material 107 assay failure 1993 MMR status available 1764 BRAF status available

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