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Investigating IL-17A and IL-22 Role in Gene Expression Using RV-GFP in AhR Models

This study explores the effects of IL-17A and IL-22 on gene expression through the RV-GFP system in various AhR knockout and wild-type models. Using advanced fluorescence techniques, we analyze the impact of these cytokines on CYP1A1 expression and other related genes. Results reveal differential mRNA expression patterns across different conditions, suggesting the involvement of AhR in mediating IL-17A and IL-22 signaling pathways. This research may provide insight into therapeutic targets for inflammatory diseases.

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Investigating IL-17A and IL-22 Role in Gene Expression Using RV-GFP in AhR Models

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  1. 4 4 4 4 10 10 10 10 40.3 0.1 0.1 0.6 53.5 0.1 3 3 3 3 10 10 10 10 2 2 2 2 10 10 10 10 1 1 1 1 10 10 10 10 59.7 37.2 71.2 28.1 46.5 62.6 0 0 0 0 10 10 10 10 3 3 0 1 2 4 0 1 2 4 3 3 0 1 2 4 0 1 2 4 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 4 4 10 10 39.9 0 0 4 10 64 3 3 10 10 3 10 2 2 10 10 2 10 1 1 10 10 1 10 60.1 36.9 63 0 0 10 36 10 4 0 1 2 3 4 0 1 2 3 10 10 10 10 10 10 10 10 10 10 0 10 4 0 1 2 3 10 10 10 10 10 IL-17A IL-22 GFP empty 4 10 0.3 6.9 3 10 IL-17A IL-22 CYP1A1 2 10 14000 120 160 140 12000 100 1 10 120 10000 80 100 61.4 31.3 8000 0 60 10 80 0 1 2 3 4 6000 10 10 10 10 10 60 40 4000 40 20 2000 20 0 0 0 Figure 3 a b RV-GFP RV-GFP-AhR RV GFP+ RV-AhR GFP+ FICZ FICZ c AhR-/- + RV-GFP relative mRNA expression AhR-/- + RV-GFP + FICZ AhR-/- + RV-AhR-GFP AhR-/- + RV-AhR-GFP + FICZ

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