1 / 9

Discovery of 4 common SNPs in the human tyrosine hydroxylase (TH) proximal promoter

Discovery of 4 common SNPs in the human tyrosine hydroxylase (TH) proximal promoter. G-801C. C-824T. G-494A. A-581G.

aerona
Télécharger la présentation

Discovery of 4 common SNPs in the human tyrosine hydroxylase (TH) proximal promoter

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Discovery of 4 common SNPs in the human tyrosine hydroxylase (TH) proximal promoter G-801C C-824T G-494A A-581G Figure 1. Discovery of four common SNPs (with flanking sequences) in the human tyrosine hydroxylase (TH) proximal promoter. A, C-824T (C/C C/T, T/T); B, G-801C (G/G, G/C, C/C); C, A-581G (A/A, A/G, G/G); D, G-494A (G/G, G/A, A/A). Red arrows indicate the SNP positions. Results are ABI-3100 sequence tracings analyzed in PolyPhred. Online I

  2. Online II

  3. Human tyrosine hydroxylase (TH) promoter:Graphical Observation of Linkage Disequilibrium (“GOLD”).4 common SNPs (minor allele freq. 0.119-0.454) spanning 331 bp. D’ D’ Promoter position 5’ of ATG Results by Lian Zhang in n=293 unrelated individuals of four different ancestries. 1-3-05. Online IIIA

  4. Human tyrosine hydroxylase (TH) promoter:Graphical Observation of Linkage Disequilibrium (“GOLD”).4 common SNPs (minor allele freq. 0.119-0.484) spanning 331 bp. D’ D’ D’ Promoter position 5’ of ATG Results by Lian Zhang in n=189 unrelated individuals of European ancestry. 1-3-05. Online IIIB

  5. Human tyrosine hydroxylase (TH) promoter:Graphical Observation of Linkage Disequilibrium (“GOLD”).4 common SNPs (minor allele freq. 0.100-0.283) spanning 331 bp. D’ D’ Promoter position 5’ of ATG Results by Lian Zhang in n=30 unrelated individuals of Asian ancestry. 1-3-05 Online IIIC

  6. Human tyrosine hydroxylase (TH) promoter:Graphical Observation of Linkage Disequilibrium (“GOLD”).4 common SNPs (minor allele freq. 0.171-0.471) spanning 331 bp. Results by Lian Zhang in n=35 unrelated individuals of Hispanic ancestry. 1-3-05. D’ Promoter position 5’ of ATG Online IIID

  7. Human tyrosine hydroxylase (TH) promoter:Graphical Observation of Linkage Disequilibrium (“GOLD”).4 common SNPs (minor allele freq. 0.090-0.410) spanning 331 bp. Results by Lian Zhang in n=39 unrelated individuals of African ancestry. 1-3-05. D’ Promoter position 5’ of ATG Online IIIE

  8. Baroreceptor slope: Downward versus upward deflections. Online IVA

  9. TH pleiotropy. Baroreceptor sensitivity as a determinant of basal norepinephrine release. Stratification by TH promoter haplotype 2. Downward deflections. Online IVB

More Related