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IL-17A

AhR -/-. AhR -/- + FICZ. 5. B6. 4. B6 + FICZ. Mean clinical score. 3. 5. 2. 4. Mean clinical score. 1. 3. 0. 2. IL-17A. ROR g t. IL-17F. 0. 2. 4. 6. 8. 10. 12. 14. 16. 18. 20. 22. 24. 26. 28. 30. 600. 120000. 1. 120000. 500. Time (days) after immunisation.

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IL-17A

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  1. AhR-/- AhR-/- + FICZ 5 B6 4 B6 + FICZ Mean clinical score 3 5 2 4 Mean clinical score 1 3 0 2 IL-17A RORgt IL-17F 0 2 4 6 8 10 12 14 16 18 20 22 24 26 28 30 600 120000 1 120000 500 Time (days) after immunisation 80000 400 80000 0 300 40000 200 0 2 4 6 8 10 12 14 16 18 20 22 24 26 28 30 40000 100 0 0 Time (days) after immunisation 0 CCR6- CCR6+ AhR IL-22 25 20 30000 15 20000 10 5 10000 0 0 Figure 4 a b 10000 8000 Absolute number of IL-17A+ CD4 6000 mRNA level to HPRT (x10-3) 4000 2000 0 B6 FICZ AhR KO c d AhR-B6 B6-AhR e

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