Tissue Engineering and Regenerative Medicine A Biomedical and Classroom Revolution
Tissue Engineering and Regenerative Medicine 1. It’s HOT! 2. It’s Relevant! Everybody is a potential candidate for its application. It helps answer the dreaded question: “Why do we have to learn all this stuff?” It’s multidisciplinary, a new trend in science and education 3. It’s a ‘Burgh Thing!
Five hottest jobs for the next millennium will be bioengineering/biomedical related. Tissue Engineering Hottest job for 21st Century
What is Tissue Engineering? • Broadly Defined: Tissue Engineering is the development and manipulation of artificial implants, laboratory-grown tissues, genetically engineered cells and/or molecules to replace or support the function of defective or injured parts of the body.
No One Discipline Can Tackle the Problem Alone Lee Weiss, Carnegie Mellon
Answering TE questions: Old School vs. New School Molecular Biology Materials Science Cell Biology Clinicians Biochemistry Chemical Engineering Computational Biology Robotics Genomics
Guided Tissue Repair If needed, harvest cells from patient. Growth factors Cells Biomimetic extracellular matrix Implant Culture Lee Weiss, Carnegie Mellon
Variations On a Theme Lee Weiss, Carnegie Mellon
Principles of TE & What are we made of? Cells ECM Defect Regeneration Blood Supply Hormones PhilCampbell, Carnegie Mellon
Tissue Structure and Function may be Compromised By: • Inherent design flaws • Hereditary/congenital defects or conditions • Disease • Trauma • Environmental influences/insults • Aging
Potential Solutions: • Surgical or physical manipulation • Drug therapy • Diet/lifestyle changes • Transplants • Artificial tissues/organs • Gene therapy • Tissue Engineering/Regenerative Medicine
Same area, NOW…
Stephen Badylak, PhD, MD, DVM SIS ECM • SIS, ECM for repair of soft tissues. Once in place, the matrix, a 3-dimensional scaffold void of cells but with structural and functional proteins still intact, serves to recruit the appropriate cells for tissue remodeling without producing scarring.
First marine mammal application of ECM tissue repair! Meet Liko, 3-year old dolphin at Dolphin Quest on Hawaii’s Big Island, Liko sustained a tear at base of his dorsal (top) fin -- likely in a game of “chase” with his dolphin cohorts. Thanks to Dr. Badylak’s SIS ECM, Liko has healed and is again performing.
An Ultimate Vision for Regenerative Medicine: Complete Tissue Regeneration Spinal Cord Upper and Lower Jaw Retina and Lens Tail Heart Limb The Newt Adapted from Brockes From Dr. Susan Bryant, Univ. of Calif., Irvine Phil Campbell, Carnegie Mellon