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INIA-West Gene Priorities

INIA-West Gene Priorities.

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INIA-West Gene Priorities

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  1. INIA-West Gene Priorities Genes identified at the January 9-10, 2013, meeting of INIA-West as priority targets for mechanism of action and medication target validation in animal models of excessive drinking. Four broad categories were identified. Drugs used to manipulate targets are in italics. Neuroinflammatory System Targets ALK TLR4 (T5342126, (+)naloxone, antagonists via MyD2) PPAR alpha, gamma (fenofibrate, tezaglitazar, agonists) IKK beta (TPCA-1, inhibitor) Pde 4 (rolipram, RO 201724, ibudilast, inhibitors) Signal Transduction Targets HYOU1 (heat shock protein) NR4a1 (transcription factor) GPR88 (G-protein-coupled) GHSR (GD-Lys, JMV2959, ghrelin antagonists) DGKzeta Ion Channel Targets Sodium channel 4b and 7a Potassium channel BK beta1 and beta 4- (paxilline, blocker) GIRK2 (KCNJ6- COGA gene) Epigenetic Targets HDAC 5 Gnb1 (G beta 1) MECP 2

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