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Supplementary Table 1. List of upregulated genes by PAUF *. Probe ID. Gene Symbol. Gene Title. Panc-1 PAUF. CFPAC-1 shPAUF. 239738_at. DACH2. dachshund homolog 2 (Drosophila). 48.9. -14.2. 206765_at. KCNJ2. potassium inwardly-rectifying channel, subfamily J, member 2. 35.2. -3.0.

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  1. Supplementary Table 1. List of upregulated genes by PAUF * Probe ID Gene Symbol Gene Title Panc-1PAUF CFPAC-1 shPAUF 239738_at DACH2 dachshund homolog 2 (Drosophila) 48.9 -14.2 206765_at KCNJ2 potassium inwardly-rectifying channel, subfamily J, member 2 35.2 -3.0 234904_x_at ELAVL4 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D) 26.9 -47.2 233465_at SPRED1 sprouty-related, EVH1 domain containing 1 13.7 -19.3 233479_at PGAP1 GPI deacylase 12.5 -2.4 225273_at WWC3 WWC family member 3 11.6 -2.2 209277_at TFPI2 tissue factor pathway inhibitor 2 10.5 -2.4 217028_at CXCR4 chemokine (C-X-C motif) receptor 4 10.2 -5.6 226690_at ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I 9.5 -2.8 227383_at no information CDNA FLJ36837 fis, clone ASTRO2011422 9.5 -2.1 1555516_at FOXP2 forkhead box P2 9.1 -13.7 231142_at ROR1 receptor tyrosine kinase-like orphan receptor 1 8.6 -2.6 209278_s_at TFPI2 tissue factor pathway inhibitor 2 7.5 -2.0 202499_s_at SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 7.2 -4.5 233720_at SORBS2 sorbin and SH3 domain containing 2 7.0 -2.1 1557647_a_at no information CDNA FLJ34880 fis, clone NT2NE2015885 6.9 -3.2 219427_at FAT4 FAT tumor suppressor homolog 4 (Drosophila) 6.8 -2.2 1562863_at EXT1 exostoses (multiple) 1 6.1 -5.7 204271_s_at EDNRB endothelin receptor type B 6.0 -2.2 234066_at IL1RL1 interleukin 1 receptor-like 1 5.4 -3.5 1558595_at FLJ23861 hypothetical protein FLJ23861 5.3 -3.6 201539_s_at FHL1 four and a half LIM domains 1 5.0 -3.0 233937_at ZNF403 zinc finger protein 403 4.8 -2.4 227769_at no information Transcribed locus, strongly similar to NP_061844.1 G protein-coupled receptor 27;super conserved receptor expressed in brain 1 [Homo sapiens] 4.2 -4.9 231969_at STOX2 storkhead box 2 4.1 -4.3 1556777_a_at no information Full length insert cDNA YN57B01 4.0 -3.6 237634_at C1QTNF3 C1q and tumor necrosis factor related protein 3 4.0 -12.9 242724_x_at NR6A1 nuclear receptor subfamily 6, group A, member 1 3.9 -2.7 206462_s_at NTRK3 neurotrophic tyrosine kinase, receptor, type 3 3.9 -8.3 237794_at LOC554226 hypothetical protein LOC554226 3.9 -19.0

  2. Supplementary Table 1 - continued Probe ID Gene Symbol Gene Title Panc-1PAUF CFPAC-1 shPAUF 206100_at CPM carboxypeptidase M 3.9 -8.1 221415_s_at GJA10 gap junction protein, alpha 10, 59kDa 3.8 -15.4 235421_at MAP3K8 mitogen-activated protein kinase kinase kinase 8 3.8 -2.7 232615_at PDE4DIP phosphodiesterase 4D interacting protein (myomegalin) 3.8 -2.2 215209_at SEC24D SEC24 related gene family, member D (S. cerevisiae) 3.7 -2.9 235706_at CPM carboxypeptidase M 3.5 -2.7 202664_at WIPF1 WAS/WASL interacting protein family, member 1 3.4 -4.3 206584_at LY96 lymphocyte antigen 96 3.4 -2.0 231513_at no information Transcribed locus 3.3 -3.9 240482_at HDAC3 histone deacetylase 3 3.3 -2.6 231165_at DDHD1 DDHD domain containing 1 3.3 -26.8 244286_at FNBP1 formin binding protein 1 3.3 -3.7 219520_s_at WWC3 WWC family member 3 3.3 -2.1 207143_at CDK6 cyclin-dependent kinase 6 3.2 -2.2 232113_at LOC399959 hypothetical gene supported by BX647608 3.2 -2.2 211429_s_at SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 3.2 -3.1 1564378_a_at EXT1 exostoses (multiple) 1 3.2 -31.5 239146_at CLDND1 claudin domain containing 1 3.2 -2.4 243054_at ZMYND11 zinc finger, MYND domain containing 11 3.1 -2.1 202665_s_at WIPF1 WAS/WASL interacting protein family, member 1 3.0 -2.2 231240_at DIO2 deiodinase, iodothyronine, type II 3.0 -3.2 234137_s_at RANBP17 RAN binding protein 17 2.9 -3.9 204530_s_at TOX thymus high mobility group box protein TOX 2.8 -3.2 224901_at SCD5 stearoyl-CoA desaturase 5 2.8 -2.2 224848_at CDK6 cyclin-dependent kinase 6 2.8 -2.3 200906_s_at PALLD palladin, cytoskeletal associated protein 2.7 -2.0 233364_s_at LOC399959 hypothetical gene supported by BX647608 2.6 -8.2 220484_at MCOLN3 mucolipin 3 2.6 -3.6 215318_at CG012 hypothetical gene CG012 2.6 -3.1 234082_at no information no information 2.6 -3.6 242913_at CLIC6 chloride intracellular channel 6 2.6 -3.0 1557252_at HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 2.6 -9.0 219906_at FLJ10213 hypothetical protein FLJ10213 2.5 -4.3 241240_at ATF6 activating transcription factor 6 2.5 -3.6

  3. Supplementary Table 1 - continued Probe ID Gene Symbol Gene Title Panc-1PAUF CFPAC-1 shPAUF 1557419_a_at ACSL4 acyl-CoA synthetase long-chain family member 4 2.5 -4.1 231145_at PAX9 paired box gene 9 2.5 -8.6 242986_at NAV1 neuron navigator 1 2.4 -3.1 232797_at ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) 2.4 -3.5 211551_at EGFR epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) 2.4 -2.2 237346_at TGDS TDP-glucose 4,6-dehydratase 2.4 -9.3 1556282_at FGFR1OP2 FGFR1 oncogene partner 2 2.4 -2.5 1569325_at ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa 2.3 -3.5 235102_x_at GRAP GRB2-related adaptor protein 2.3 -8.7 235176_at ZNF545 zinc finger protein 545 2.3 -3.6 237189_at no information Transcribed locus, strongly similar to NP_002137.3 homeo box B3;homeo box 2G;homeobox protein Hox-B3 [Homo sapiens] 2.3 -3.8 1569961_at no information Homo sapiens, clone IMAGE:2960615, mRNA 2.3 -2.1 238137_at PLRG1 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) 2.3 -4.6 1554131_at KIAA1128 KIAA1128 2.3 -3.0 243673_at RBM41 RNA binding motif protein 41 2.3 -3.3 1569490_at FNDC3B fibronectin type III domain containing 3B 2.2 -2.7 210004_at OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 2.2 -3.2 244755_at no information no information 2.2 -4.1 41856_at no information Full-length cDNA clone CL0BB018ZE07 of Neuroblastoma of Homo sapiens (human) 2.2 -2.2 1565974_at SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila) 2.2 -2.6 210680_s_at MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) 2.2 -2.7 1558732_at no information no information 2.1 -3.5 236288_at RNF34 ring finger protein 34 2.1 -2.3 235756_at SAMD4A sterile alpha motif domain containing 4A 2.1 -2.7 207234_at RFX3 regulatory factor X, 3 (influences HLA class II expression) 2.1 -7.4 208039_at no information no information 2.1 -3.0 238757_at DBF4B DBF4 homolog B (S. cerevisiae) 2.1 -2.3 234704_at no information no information 2.1 -7.8 224405_at FCRL5 Fc receptor-like 5 2.1 -32.6 222141_at KLHL22 kelch-like 22 (Drosophila) 2.1 -2.1

  4. Supplementary Table 1 - continued Probe ID Gene Symbol Gene Title Panc-1PAUF CFPAC-1 shPAUF 241769_at ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) 2.1 -2.9 206157_at PTX3 pentraxin-related gene, rapidly induced by IL-1 beta 2.1 -2.8 230672_at no information CDNA clone IMAGE:4841343 2.1 -2.2 1557018_a_at no information CDNA clone IMAGE:5312582 2.0 -4.5 240365_at LOC647946 hypothetical protein LOC647946 2.0 -2.0 1562960_at LOC338653 hypothetical protein LOC338653 2.0 -8.9 204567_s_at ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 2.0 -3.9 202637_s_at ICAM1 intercellular adhesion molecule 1 (CD54), human rhinovirus receptor 2.0 -2.8 221155_x_at no information PRO1496 2.0 -2.7 228632_at no information CDNA FLJ37243 fis, clone BRAMY2004387 2.0 -2.9 *List of 96 genes (104 fragments) expressed at levels more than two-fold higher in Panc-1_PAUF than in Panc-1_Mock and more than twofold lower in CFPAC-1_shPAUF than in CFPAC-1_shCtrl.

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