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S31

>0.5. >0.8. ESM Figure 1. a. S31. S30. S29. S28. S27. S26. S25. r 2. S22-24. 1.0. S21. S20. S18-19. S15-17. S11-14. S9-10. S7-8. S6. 0.0. S5. S4. S3. S2. S1. SNPs. S1. S31. b. Control group (n=893). T2D group (n=909). ESM Figure 1

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S31

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  1. >0.5 >0.8 ESM Figure 1 a S31 S30 S29 S28 S27 S26 S25 r2 S22-24 1.0 S21 S20 S18-19 S15-17 S11-14 S9-10 S7-8 S6 0.0 S5 S4 S3 S2 S1 SNPs S1 S31 b Control group (n=893) T2D group (n=909)

  2. ESM Figure 1 • Pairwise LD of 31 SNPs from the 211.3-kb genomic region containing KCNJ11, ABCC8 and neighboring known genes NUCB2 and DKFZp686I21167 (hypothetical gene). SNP numbers correspond to ID numbers in Table 1. Color-coded r2 values for pairs of SNPs are plotted using the GOLD program, with scores of 1 (shown in red) and 0 (in dark blue). • (b) LD patterns for 8 SNPs showing significant allelic association with T2D by the single-locus test. Pairwise LDs were measured by |D’| (lower left) and r2 (upper right) using genotype data obtained from 893 control subjects or 909 T2D subjects. Pink or red squares shaded indicate significant LD: pink for (|D’| or r2)>0.5 and red for (|D’| or r2)>0.8.

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