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Drugs for Peptic Ulcer Disease

Chapter 73. Drugs for Peptic Ulcer Disease. Drugs for Peptic Ulcer Disease. Peptic ulcer disease Upper GI disorders Degrees of erosion of the gut wall Cause Imbalance between mucosal and aggressive factors. Defensive factors Mucus Bicarbonate Blood flow Prostaglandins.

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Drugs for Peptic Ulcer Disease

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  1. Chapter 73 Drugs for Peptic Ulcer Disease

  2. Drugs for Peptic Ulcer Disease • Peptic ulcer disease • Upper GI disorders • Degrees of erosion of the gut wall • Cause • Imbalance between mucosal and aggressive factors

  3. Defensive factors Mucus Bicarbonate Blood flow Prostaglandins Aggressive factors Helicobacter NSAIDs Gastric acid Pepsin Smoking Pathogenesis of Peptic Ulcers

  4. Classes of Antiulcer Drugs • Antibiotics • Antisecretory agents • Mucosal protectants • Antisecretory agents that enhance mucosal defenses • Antacids

  5. Helicobacter pylori • Test: breath test or serum • Treatment—(two antibiotics are prescribed) • Bismuth • Clarithromycin • Amoxicillin • Tetracycline • Metronidazole

  6. Histamine-2 Receptor Antagonists • Cimetidine (Tagamet) • Ranitidine (Zantac) • Ranitidine bismuth citrate (Tritec) • Famotidine (Pepcid) • Nizatidine (Axid)

  7. Proton Pump Inhibitors • Omeprazole (Prilosec) • Inhibits gastric secretion • Short half-life • Used for short-term therapy • Adverse effects • Headache • Gastrointestinal

  8. Sucralfate (Carafate) • Protective barrier up to 6 hours • Uses • Acute ulcers • Adverse effects • Constipation • Drug interactions

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