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Purinsynthese

This text summarizes the complex biochemical pathways involved in the synthesis of purines and glutamate, detailing key intermediates such as 5-Phosphoribosyl-1-amin, ATP, ADP, and various amino acids like glutamine, aspartate, and glycine. The roles of co-factors and processes involving ammonia (NH3) as well as energy molecules like NADH and GTP are highlighted. This synthesis is crucial for cellular metabolism and energy transfer, showcasing the interconnected nature of metabolic pathways.

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Purinsynthese

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  1. Purinsynthese

  2. +NH3 O C O O O O O +NH3 P P C -OOC CH2 CH2 COO- P P H2N C C CH2 CH2 COO- H O O O H O HO OH O C O O O O O P P O O O O HO OH Glutamin Glutamat NH2 5-Phosphoribosyl-1-amin 5-Phosphoribosyl-1-pyrophosphat (PRPP) W. Storch D. Doenecke

  3. ATP +NH3 +NH3 P C -OOC CH2 CH2 COO- H2N C C CH2 CH2 COO- H H O O O C C H H THF H O C O +NH3 H C COO- O O HO OH CH2 P C O OH O Glycin Glutamin Glutamat +NH3 NH THF H NH2 CH2 N C N O H Phosphoribosylamin ADP

  4. ATP ATP ATP P O HO O THF O C C C H CH2 H O + O C C H3N H O O O C N N N N HC HC HC HC HO HO C N HC N N HC HC H NH C C O O O O O O O O O O O HO OH O N N N N C C C C O H N N N CH C CH CH2 CH N C C C CH2 CH P P P C C C C C C O O O OH OH OH O C C C C C C C HN NH2 NH2 H H O NH NH2 N N NH2 O HN NH2 NH2 H N HO C C H C C C H O O O O O O Bicarbonat Fumarat Aspartat THF H2O ADP ADP Inosinat (IMP) ADP

  5. GTP P O HO C O CH2 HO + O C C C H3N H O O N N HC HC CH2 HO C C O C HN H HO OH O N N O O C C O CH P C C C C C O O C H O NH N N N O C C C H H O O NH2 Aspartat Fumarat H GDP Inosinat (IMP) Adenylat (AMP)

  6. ATP H2O +NH3 +NH3 P C -OOC CH2 CH2 COO- H2N C C CH2 CH2 COO- H H O NADH+H+ O NAD C O N N N HC HC HC HO OH N N N C C C O O O C C C C C C N NH NH HN HN N C C C H O Glutamin Glutamat H AMP NH2 Inosinat (IMP) Guanylat (GMP)

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