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An Ontology for Clinical Trial Data Integration

An Ontology for Clinical Trial Data Integration. Dr. Ratnesh Sahay SMC 2013, Manchester, UK 15-10-2013. If you have heterogeneous clinical terminologies and you want to integrate them…. and if scale of integration grows …. ?. E. A. B8. A4. F. A1. B3. The Problem.

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An Ontology for Clinical Trial Data Integration

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  1. An Ontology for Clinical Trial Data Integration Dr. Ratnesh Sahay SMC 2013, Manchester, UK 15-10-2013

  2. If you have heterogeneous clinical terminologies and you want to integrate them…. and if scale of integration grows… ? E A B8 A4 F A1 B3 The Problem Heterogeneous Clinical Terminologies Lot of complex terminologies B3 A1 B3 B3 B8 A1 A1 A4 B3 A1 A1 A1 A1 A1 A1 A2 A4 A1 A2 A2 A4 A2 A4 A4 B3 A1 A1 A5 A1 A2 A4 A2 A1 B3 A1 B3 A1 A1 B3 A1 B3 A1 A1 A1 A1 A4 A4 A6 A1 A1 A2 A4 B3 A4 A1 A1 A1 A1 A1 A1 A2 A1 A4 B3 A1 A2 A1 A4 A1 A1 A1 A2 A4 A1 A1 A4 B3 A2 A1 A4 B3 A2 A1 A1 A1 A1 A4 A4 A1 A1 A1 A1 A1 A1 A1 A2 A2 A1 A1 B3 A2 A4 A2 A2 A1 A4 A1 A1 A2 A4 A1 Terminology Integration A4 A2 A2 A2 A4 A1 B3 A4 A4 A1 A1 A1 A1 A1 A2 A4 A4 A2 A1 A4 A1 A1 A4 A1 A1 B3 A1 A1 A1 B3 A2 B3 A1 A1 A4 A2 B3 A2 A4 A1 A1 A1 A4 B3 A1 A1 A2 A2 A1 A4 A4 A1 A1 A1 B3 A4 B3 A1 A1 A1 A1 A2 A2 A1 A4 A1 A2 A1 A4 A1 A1 A1 A2 A2 A1 A4 A1 A4 A1 A4 A1 A4 A1 A1 B3 A1 A1 B3 B3 A1 B3 A1 B3 A1

  3. Integrating Clinical Terminologies Legal and Ethical Regulations HL7/openEHR • return number of subjects (i.e., patients) that have been administered the drug Insulin and exhibit BMI > 25 and Dyslipidemiaand Agoraphobiaas adverse events DSM-4 LOINC SNOMED RxNorm 3/7

  4. Semantic EHR Ontology • The Semantic EHR Ontology represents the clinical trail domainand described as a domain level ontology • Objectives • Enable sharing and linking of healthcare and clinical terminologies • Sharing consistent and unambiguous knowledge for decision making in medical and clinical research domains • (Sub)Domains • Partially covers Breast Cancer, Diabetic, Adverse Event (AE), Concomitant Medication (CE), Neurology, Genetics, PsychiatricDisorder, and Respiratory • Local institute (domain)-specific variables 4/7

  5. Layering: Semantic EHR Ontology UMLS, OBO Foundry (Basic Formal Ontology) BFO UPPER imports ACGT imports Advancing Clinico-Genomic Trials on Cancer (ACGT) SEHR ZEINCRO Adverse Event (AE) Concomitant Medication (CE) Respiratory Domain CHUV Cardiovascular Psychiatric Adverse Events CING Breast Cancer Diabetic Neurology Genetics Adverse Event (AE) 5/7

  6. Evaluating Semantic EHR Ontology • The questionnaires were answered by clinical experts from various sub-domain of Healthcare and Life Sciences • Clinical experts suggested conceptualisation fixes (i.e., hierarchy and/or names of classes and properties) that suit their local requirements • Clinical experts agree that SEHR ontology covers the needs of the clinical trial domain • We are doing a final (fourth) round of evaluation 6/7

  7. Thank you 7/7

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