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Comprehensive Analysis of LRH-1 Variants Across Multiple Species

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This study presents an in-depth examination of LRH-1 protein variants across diverse species, including humans, mice, chickens, Xenopus, and zebrafish. We compare variants V1 through V5 from various organisms, analyzing their amino acid sequences and potential functional implications. The investigation provides insights into evolutionary conservation and divergence in LRH-1 function, highlighting critical sequence alignments that may inform future biological research. Supplementary data, including figures and sequence details, support our findings.

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Comprehensive Analysis of LRH-1 Variants Across Multiple Species

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  1. A B 11.7 kb Human LRH-1-V1 Human LRH-1-V4 Human LRH-1-V5 Mouse LRH-1-V1 Mouse LRH-1-V2 Chicken LRH-1 Xenopus LRH-1 Zebrafish LRH-1 C HUMAN V1 1 MSSNSDTGDLQESLKHGLTPI---------------------GAGLPDRHGSPIPARGRLVMLPKV 45 Human V2 1 MSSNSDTGDLQESLKHGLTPI--------------------------------------------- 21 Human v4 1 -------------------------------------------------------------MLPKV 5 Human v5 ------------------------------------------------------------------ Mouse V1 1 MSASLDTGDFQEFLKHGLTAIASAPGSETRHSPKREEQLREKRAGLPDRHRRPIPARSRLVMLPKV 66 Mouse V2 1 -------------------------------------------------------------MLPKV 5 CHICKEN 1 -------------------------------------------------------------mlpkv 5 xenopus 1 -------------------------------------------------------------mlpkv 5 ZEBRAFISH 1 -------------------------------------------------------------MLPKV 5 Human v1 46 ETEALGLARSHGEQGQMPENMQVSQFKMVNYSYDEDLEELCPVCG 90 Human v2 22 ----------------------VSQFKMVNYSYDEDLEELCPVCG 69 Human v4 6 ETEALGLARSHGEQGQMPENMQVSQFKMVNYSYDEDLEELCPVCG 50 Human v5 1 -----------MATQAGQLQAKVSQFKMVNYSYDEDLEELCPVCG 34 Mouse v1 67 ETEAPGLVRSHGEQGQMPENMQVSQFKMVNYSYDEDLEELCPVCG 111 MOUSE V2 6 ETEAPGLVRSHGEQGQMPENMQVSQFKMVNYSYDEDLEELCPVCG 50 CHICKEN 6 etealglarsngeqgqmpenmqvsqfkmvnysydedleelcpvcg 50 XENOPUS 6 epealglsrshgeqghmpenmqasqfkmmgysydeeleemcpvcg 50 ZEBRAFISH 6 ESEYLGLARSHGEQGHMPGNMQAPQFKMMDYSYDEDLDEMCPVCG 50 Thiruchelvam et al Supplementary Figure 1

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